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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects on goats of Calotropis procera latex given by different routes of administration were investigated. The administration of latex at 1 ml/Kg body weight via the oral route or at 0.005 ml/Kg body weight/day via the intravenous or intraperitoneal route caused death of the goats between 20 minutes and 4 days. When the small dose of latex (0.005 ml/Kg body weight/day) was given by the oral route or intramuscular route no death among the goats occurred. Nervous signs, frequent urination, frothing at the mouth, dyspnoea and diarrhoea were the main features in goats given latex by the oral, intravenous or intraperitoneal route. Lameness was observed in goats given latex via the intramuscular route. Lesions were widespread congestion and haemorrhage, pulmonary cyanosis, enterohepatonephropathy, peritonitis (in goats receiving latex via i.p. route) and haemorrhagic myositis at the site of latex injection. These changes were accompanied by increases in the activities of serum GDH, LDH, ALP, GGT and AST and in the concentrations of cholesterol, urea and creatinine and decreases in the level of total protein.
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PMID:Studies on laticiferous plants: toxic effects in goats of Calotropis procera latex given by different routes of administration. 985 66

The effect of an ethanol extract of Commiphora myrrha oleo-gum resin on hematological and pathophysiological parameters of male Wistar rats was examined. The extract was given daily for 2 w at 1000 mg/kg bw per os, 500 mg/kg bw i.m. or 250 mg/kg bw i.p. Depression, huddling together, soft feces, jaundice, ruffled hair, hepatonephropathy, hemorrhagic myositis and patchy peritonitis (at the injection site) and death were accompanied by increases in serum ALP and ALT activities, bilirubin, cholesterol and creatinine concentrations, and decreases in total protein and albumin levels, and macrocytic anemia and leucopenia. When administered at 500 mg extract/kg bw/d per os or 250 mg extract/kg bw/d i.m. for 2 w it was not lethal, and when given daily for 1 w the effect was less marked.
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PMID:Effects on rats of Commiphora myrrha extract given by different routes of administration. 1043 69