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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Circumscribed heterotopic new-bone formation without a history of trauma is termed pseudomalignant myositis ossificans due to the diagnostic confusion of this benign lesion with malignant lesions. In 20 per cent of the published cases in which there were diagnostic problems, the patient underwent a radical procedure. Roentgenographically, pseudomalignant myositis ossificans is a circumscribed, radiopaque lesion with a central lucent zone that is separated from the underlying cortex by a radiolucent line. Histologically, a characteristic zoning pattern of peripheral maturation is present, the central proliferating zone usually causing the diagnostic problems. The ultrastructure of the lesion shows a regular mineralization front but an abnormal collagen periodicity of 300 angstroms. Excision is indicated for diagnosis and for relief of mechanical block or pain.
J Bone Joint Surg Am 1980 Dec
PMID:Pseudomalignant myositis ossificans: heterotopic new-bone formation without a history of trauma. 693 74

Nine cases of fibromatosis occurring in or near the oral cavity are presented here. They are classified as nodular fasciitis (3 cases), aggressive infantile fibromatosis (2 cases), fibrosing myositis (1 case) and fibromatosis (1 case). Of the 5 cases of nodular fasciitis, 3 occurred from the fascia of the masticatory muscle and 2 from the submucous fascia of the palate and tongue. The aggressive infantile fibromatosis showed a prominent infiltrating growth and an alarming histologic appearance. One of the 2 cases showed a recurrence, but the postoperative course of both cases was uneventful for 13 years and 10 years, respectively. The fibrosing myositis is an unusual fibromatosis of the muscle, which arose within the tongue muscle. The lesion was benign and can be cured by conservative surgery.
Bull Tokyo Med Dent Univ 1982 Dec
PMID:Fibromatosis of the oral cavity. 695 37

This study was attempted to obtain information about biological properties of junctional acetylcholine receptor (AChR) and extrajunctional AChR, and about nerve influences on muscles AChRs under the pathological conditions of experimental myasthenia and myositis. Experimental autoimmune myasthenia gravis (EAMG) was induced in Wistar rats by immunizations with AChR purified from the electric organ of Narke Japonica without using Freund's complete adjuvant experimental myositis by immunization with rat muscle extract depleted of AChR. Thirty-five days after the initial immunization, unilateral dissection of the ischiadic nerve was performed in all immunized rats. Contents of AChR in both hind limb muscles were measured by double immunoprecipitation assay method 15 days after the experimental denervation. In the control animals the amount of AChR extractable from innervated muscles was 2.7 +/- 0.5 (mean +/- s.d.) pmole/g muscle and increased about 10-fold 15 days after the denervation (30 +/- 7.9). In rats with EAMG, AChR contents was reduced in both denervated (1.1 +/- 1.0) and innervated muscles (1.3 +/- 0.9). In experimental myositis, the increase of muscle AChR was impaired in denervated muscles (2.4 +/- 0.6), but AChR contents was not reduced in innervated muscles (2.7 +/- 0.9). These results suggest that nerves may influence AChR metabolism, keeping numbers of AChR constant even in inflammatory condition. In addition, germinal centre formation in thymic medulla was detected in EAMG rats.
Clin Exp Immunol 1982 Dec
PMID:Acetylcholine receptor and thymus in experimental autoimmune myasthenia gravis and experimental myositis. 716 99

Histologic, physical and chemical analyses of the excised bony mass from a case of myositis ossificans traumatica were carried out. X-ray diffraction showed that the newly formed bone was an intermediate fluor-hydroxylapatite. Infrared spectroscopy and chemical analysis supported this finding. Contrary to articular free bodies the mineral part of the bony mass from the myositis ossificans investigated was formed most probably in a basic environment.
Acta Orthop Scand 1980 Dec
PMID:Histologic, physical and chemical investigation of myositis ossificans traumatica. 721 Dec 93

Intracompartmental muscle pressures were recorded from the right and left forelimbs (extensor carpi radialis, triceps brachii) of healthy horses maintained in left lateral recumbency while under deep halothane anesthesia for 180 to 240 minutes. Cardiac output, blood pressure, blood gases, and acid-base status were monitored throughout the anesthesia, and electrolyte levels (Ca2+, P+, K+, Cl-, Na+) and enzyme activities (aspartate aminotransferase (AST), creatine phosphokinase (CPK), and blood lactate) were monitored for 7 days. Postanesthetic forelimb lameness was produced in 5 of the 6 horses with this prolonged anesthetic regime. This lameness was associated with muscle plaque formation and clinical signs which were similar to the forelimb lameness sometimes seen in horses after surgical anesthesia. Plasma protein, serum calcium, plasma sodium, and blood urea nitrogen concentrations did not change, whereas significantly increased hematocrit, plasma potassium, and serum inorganic phosphate values were seen at the end of anesthesia, along with a decrease in plasma chloride values. Blood lactate, serum AST, and serum CPK activities were significantly high in the postanesthetic period, although the sequence of the changes differed. Intracompartmental muscle pressures were higher in the left forelimb adjacent to the floor (contact limb), and in the instance of the triceps of the contact limb, the pressures were sufficiently high (greater than 30 mm of Hg) that they may have compromised capillary blood flow. However, these high intracompartmental muscle pressures did not persist when positional changes of the horses were introduced at the end of the anesthetic period. There was no correlation between the severity of postanesthetic lameness and any of the measured values. The results demonstrate an experimentally induced postanesthetic lameness which was primarily related to the development of a myositis. Although the causative factors of this myositis may be multiple, the present study implicates local hypoxia in that increased blood lactate and inorganic phosphate values preceded that increased CPK activity. Intracompartmental muscle pressure in the contact limb were possibly high enough to have restricted local capillary blood flow.
Am J Vet Res 1980 Dec
PMID:Equine postanesthetic forelimb lameness: intracompartmental muscle pressure changes and biochemical patterns. 721 25

Studies were performed to ascertain the effects of transplantation of thymic cells exposed in vivo to 3-methylcholanthrene (3-MC) on the induction of malignancies in Copenhagen rats. Three recipient rats unexpectedly developed tumors which bore histological resemblance to myositis ossificans of humans. Specifically, histology revealed areas of peripheral ossification with the appearance of zones of primitive osteoid with a central cellular area. Other areas of the lesions were less well organized into characteristic zones or were more or less heterogeneous. The primary, as well as recurring, lesions appeared in the axilla and were well circumscribed, 24-68 g in weight and 2-7 cm in diameter. Flow cytometric analyses of DNA content indicated that these tumors contained cells with abnormal DNA characteristics as well as proliferating cells. Coupled with the observation that after excision these tumors recurred, the data suggest that these myositis ossificans lesions were malignancies.
Exp Mol Pathol 1994 Dec
PMID:Induction of recurring myositis ossificans by intrathymic injection of 3-methylcholanthrene-treated cells in rats. 760 Dec 69

Multifocal myositis was diagnosed in a 7-year-old Quarter Horse gelding on the basis of history and findings on physical examination, serum biochemical analysis, electromyography, and microscopic examination of frozen sections of muscle biopsy specimens. Histologic examination of the muscle specimen revealed multifocal accumulations of histiocytes, lymphocytes, and plasma cells, with attendant myofiber degeneration and necrosis. Parasitic cysts with morphologic characteristics of Sarcocystis sp were found in regions of myocyte degeneration and necrosis, and in regions of normal muscle. Based on a tentative diagnosis of Sarcocystis sp-induced myositis, the horse was treated with trimethoprim/sulfamethoxazole and pyrimethamine for 28 days, phenylbutazone for 5 days, and paddock rest for 30 days. At the end of treatment, the horse had gained 35 kg, its appetite had returned to normal, and muscle mass was returning to normal. Sarcocystis fayeri is the only Sarcocystis sp reported in equine muscle in the United States and is rarely associated with acute myositis or muscle atrophy. The development of clinical signs in this horse could have been the result of an underlying immunosuppression or infection with a particularly pathogenic strain or large infective dose of S fayeri.
J Am Vet Med Assoc 1994 Dec 01
PMID:Multifocal myositis associated with Sarcocystis sp in a horse. 773 Jan 27

We describe a child who was treated for 10 years with etidronate disodium for myositis ossificans. There were no typical bouts of swelling, reddening or hardening of areas over the skeletal muscles with this treatment and there were no side effects. Nevertheless, a constant gradual progression of the disease led to severe limitation of joint movement. This is the first report on long-term treatment with etidronate disodium.
Acta Paediatr 1994 Dec
PMID:Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium. 773 85

A case of interstitial myositis associated with a localised lipoatrophy is reported. The patient is a 24 year old man who presented with severe painful cramps and fasciculations localised to one limb. The rarity of both disorders, and their likely common autoimmune mechanism, suggest that this is not a chance association.
J Neurol Neurosurg Psychiatry 1994 Dec
PMID:A patient with one limb interstitial myositis with localised lipoatrophy presenting with severe cramps and fasciculations. 779 89

Somatostatin receptor scintigraphy with 111In-labeled octreotide proves to be a very sensitive diagnostic tool for evaluation of inflammative activity in endocrine ophthalmopathy (EO). The results of somatostatin receptor scintigraphy (SRS) in 40 patients with EO show a high orbital accumulation of 111In-octreotide in clinically active EO (4 h-median/orbit-brain-ratio: 12.6; controls 4 h-median: 5.8) Patients with clinically inactive EO (4 h-median: 7.1) show a similar orbital accumulation of radioactivity compared to controls. 5 patients with active orbital myositis also revealed an even higher orbital accumulation of radioactivity (4 h-median: 42.3). The diagnostic value of SRS lies in its ability to act as a measure of inflammation and can be useful as an activity parameter when planning therapeutic procedure as well as for EO follow-up. The results in patients with orbital myositis nevertheless do not permit a differential diagnosis with this method. The therapeutic value of 111In-octreotide in Graves' disease has yet to be established.
Rofo 1994 Dec
PMID:[Somatostatin receptor scintigraphy in endocrine orbitopathy]. 780 69


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