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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical picture, biological findings and outcome of acute myositis during recovery from influenza are so characteristic that can clearly cut-off it from other diseases affecting the muscles. Five cases of acute bilateral lower-limb myositis are described. A flu-like illness had begun to wane before the onset of severe leg pain, preventing the children from walking. All had abnormal serum CPK and SGOT levels. Virological studies were performed with negative findings. The pathogenic mechanism is unknown. We though that more aggressive studies are not justified in view of the transient nature of the patient's illness and their complete recovery. We stress the need of recognizing such disease in every child complaining of lower leg pain associated with very painful walking into a epidemiological setting of a "influenza-like" illness. We also have reviewed the published bibliography is considered.
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PMID:[Acute transient myositis after influenza]. 328 37

Rhabdomyolysis can appear secondarily in the course of many different diseases, but also primarily as "idiopathic paroxysmal rhabdomyolysis" (i.p.r.), simulating clinically an acute myositis. Different factors can trigger this muscle reaction, the most important of them being physical stress, alcoholism, drug dependence, general anesthetics. In many of these cases biopsy investigations do disclose, out of rhabdomyolysis, a preexistent myopathy, usually dysmetabolic in origin, and often with familial incidence (lipid myopathies; carnitine palmityl-transferase deficiency; mitochondrial myopathies; glycogenoses; hypokaliaemia--but also central core diseases, tubular aggregates myopathy a.s.o.). Exact morphological and biochemical investigations are therefore needed in every case of i.p.r., with the purpose to identify the underlying myopathy in the patients and their relatives. Repeated controls of CPK values should be performed. Bearers of such subclinical myopathies have in fact to be considered patient at-risk if exposed to stress or if submitted to general anesthesia.
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PMID:[Idiopathic paroxysmal rhabdomyolysis and clinically latent myopathy]. 664 96

We report 3 male patients with a unique eosinophilic myositis of unknown etiology who appear to have a benign course. The most striking feature in 2 patients was relapsing myalgias with lower extremity predilection and tendency for spontaneous recovery. Laboratory studies showed peripheral eosinophilia, elevated CPK, and EMG consistent with a myositic pattern. Muscle biopsies showed myositis characterized by focal necrosis and degeneration with an inflammatory infiltrate predominantly composed of histiocytes and eosinophils. Skin and fascia were normal.
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PMID:Relapsing eosinophilic myositis. 688 71

In nearly 60% of men over 50 years of age, dermato-/polymyositis is induced by malignancies. Till now, 9 patients with melanoma-induced dermatomyositis have been reported in the literature. Here we report on a patient suffering from classic pelvic and pectoral girdle proximal weakness, typical heliotrope rash, increased serum CPK values, and biopsy-proven myositis, who died from metastasizing melanoma one year later.
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PMID:[Dermatomyositis as a complication of a metastatic melanoma-- case report and review of the literature]. 769 9

This report describes six diffuse scleroderma (PSS) patients with skeletal muscle myositis accompanied by severe myocarditis, diagnosed by CPK-MB elevation in conjunction with severe left ventricular (LV) hypokinesis. Although the myositis improved with steroid therapy in all patients, those treated with steroids alone died due to progressive LV failure. This experience suggests that the LV dysfunction in PSS patients with myositis may have an inflammatory component. Since the myocarditis may not be clinically apparent initially, it is suggested that CPK-MB fractionation and studies of LV function are undertaken in all PSS patients with myositis. The optimal treatment of this disorder, however, has yet to be determined.
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PMID:Myocarditis as a complication in scleroderma patients with myositis. 816 76

Some patients of dermatomyositis (DM) with interstitial pneumonia (IP) have common clinical features. Clinical features of these patients are acute onset, very poor prognosis and that patients have fever, arthritis, typical skin rash, mild myositis and show low ratio of CPK/LDH, low incidence of antinuclear antibody (ANA) appearance, low inflammatory signs. We experienced two cases of this category of DM with IP and examined immunological aspects. Case 1. A 52-year-old woman was admitted in June 1, 1990 with a one-month history of arthralgia and a ten-days history of fever, skin rash, myalgia and dyspnea on exertion. On examination she had Gottron's papules on her fingers, erythema on back, bilateral elbows and legs, proximal muscle weakness and arthritis. Fine crackles were audible in the lower lung fields. Laboratory data included CPK 200 IU/l, ALD 3.2 IU/l, LDH 805 IU/l. Analysis of bronchoalveolar lavage fluid (BALF) revealed increased cellularity with lymphocytosis. She was treated with oral corticosteroid (CS), pulse CS, cyclosporin A. Inspite of these therapies, she died of progressive respiratory insufficiency in July 10, 1990. Case 2. A 23-year-old woman was admitted in April 1, 1991, with a two-month history of arthralgia and a one-month history of fever, skin rash, stomatitis, alopecia. On examination she had Gottron's papules on her fingers, erythema on malar, bilateral elbows and legs, arthritis and stomatitis. Laboratory data included CPK 97 IU/l, ALD 8.5 IU/l, LDH 779 IU/l. She began experiencing dry cough and dyspnea on exertion in May 1991. Analysis of BALF revealed increased cellularity with lymphocytosis. She was treated with oral corticosteroid(CS), pulse CS, pulse cyclophosphamide.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Two cases of acute progressive interstitial pneumonia associated with dermatomyositis--clinical features and immunological disorders]. 823 10

We report a case of dermatomyositis (DM) in a 15-year-old female with toxoplasmosis after ingestion of raw bovine liver. Facial erythema and cervical lymphadenopathy preceded myalgia and muscle weakness of the extremities. The diagnostic criteria of DM was fulfilled because of symmetrical and proximal dominant muscle weakness, elevation of myogenic enzyme (CPK, GOT, LDH, myoglobin, aldorase), myogenic pattern of electromyogram, skeletal muscle biopsy showing interstitial myositis with mild destruction of muscle fiber, and facial erythema. Immunological findings showed IgG anti-toxoplasma antibody to be 1340 IU/ml and IgM to be 7.0 (Cut off index 0.7), suggesting acute toxoplasmosis. Treatment with prednisolone for DM and acetylspiramycin for toxoplasmosis was successful. Toxoplasmosis should be considered as a possibility in patients with myositis.
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PMID:[A case of toxoplasmosis with dermatomyositis]. 870 14

A 69-year-old woman was admitted to our hospital because of slight fever, general fatigue, joint pain and proximal muscle weakness. Severe elevation of serum enzyme levels of CPK, transaminase and aldolase was noted. The chest roentgengram showed diffuse reticular and nodular infiltrates. Histological examination of the transbronchial lung biopsy specimens revealed alveolitis and organizing pneumonia. Daily administration of 80 mg predonisolone was effective for both lung findings and myositis.
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PMID:[A case of polymyositis presenting histological picture of bronchiolitis obliterans organizing pneumonia with transbronchial lung biopsy specimens]. 872 Feb 70

The authors report a case of granulomatous myositis in a child (the cases in literature begin between 13 and 72 years). Our case is peculiar because the histological report of granulomatous myositis was accompanied by an important rise in serum CPK level without any symptoms of muscular disease. The serum CPK level, for 18 months, fluctuated between 4.190 and 22.960 UI/L while no symptom occurred. The authors complete the article with a review of the literature about the granulomatous myositis.
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PMID:[Granulomatous idiopathic myositis at pediatric onset. Description of a case and a review of literature]. 892 67

A 56-year-old man experienced dyspnea since August 1995 and the chest X-ray film showed abnormal shadow. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was established based on the histological findings of transbronchial lung biopsy. The patient was treated with prednisolone and symptoms improved. Myalgia and muscle weakness developed associated with relapse of BOOP after withdrawal of prednisolone. Patient was admitted to our department on December 1995 for further examination. An increased level of serum CPK, histological findings of muscle biopsy consistent with myositis, and positive anti-Jo-1 antibody were identified. Those findings supported a diagnosis of polymyositis (PM), and BOOP was considered as a pulmonary complication of PM. Myositis and pulmonary lesion improved after second course of steroid therapy and patient was discharged on May 1996. Both chronic pulmonary fibrosis and acute progressive interstital pneumonia are well known as pulmonary lesion associated with PM. The former is frequently recognized in cases of PM with anti-Jo-1 antibody and the latter is often observed in cases without autoantibodies. The association of PM and BOOP, however, has rarely been reported. The findings that BOOP frequently preceded PM and anti-Jo-1 antibody was positive in half of the cases were observed in the literature.
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PMID:[A case of polymyositis with anti-Jo-1 antibody preceded by BOOP]. 966 82


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