Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027121 (
myositis
)
4,538
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thirty-six biopsy specimens of human biceps and vastus lateralis muscles were examined by histometric analysis and determination of enzyme activities (phosphorylase, triosephosphate dehydrogenase, 3-hydroxacyl-CoA-dehydrogenase, lactate dehydrogenase, hexose isomerase, citrate synthetase,
6-phosphogluconate dehydrogenase
). The series included 13 specimens from patients suffering from a benign form of muscular dystrophy (limb girdle and Becker type of muscular dystrophy) and 12 specimens from patients with an acute (n = 5) or chronic (n = 7) form of
myositis
. Muscle fibres were atrophic in
myositis
and hypertrophic (with an increased variation of fibre diameters) in muscular dystrophies, as has been shown previously. When
myositis
samples were compared with either normal or dystrophic muscles, a highly significant lowering of glycolytic enzyme activity was found in chronic
myositis
, while the activity of
6-phosphogluconate dehydrogenase
was elevated to highly significant levels. Measurements of the latter enzyme's activity might be of additional value in differentiating chronic forms of
myositis
from benign muscular dystrophies.
...
PMID:Additional biochemical criteria in the differential diagnosis of myositis. 343 Jan 87
