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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The quantitative distribution of the Conn.-5 strain of Coxsackie virus in different tissues was determined by serial titration at intervals after inoculation of 4 to 5 day old mice. High titers were reached by the 2nd day in blood, heart, liver, muscle, intestine, and its contents, and these were maintained through the 8th day, except for the blood, in which the virus level fell earlier. In paralyzed mice, muscle and brain attained the highest titers and it was in these tissues alone that virus persisted through the 9th day of illness. The pathology of the infection has been briefly described. In particular, the evolution of morbid changes in striated muscle was correlated with the concentrations of virus in muscle. Acute muscle necrosis first occurred when there was a peak viral concentration (4th day), and reached maximal intensity on the 8th day. Scattered acute lesions continued to appear while the virus titer remained above 10(-4), from the 9th to 12th day. With the decrease in the myositis, there was a concomitant decrease in the incidence of perceptible disease. Inflammation was found to follow upon the development of necrosis, and subsided slowly. Regeneration began very early, became exuberant, and led finally to restitution of the muscle.
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PMID:Pathogenesis of coxsackie virus infection; multiplication of virus and evolution of the muscle lesion in mice. 1482 99

A STUDY HAS BEEN MADE OF THE LESIONS PRODUCED IN SUCKLING MICE BY THE FOLLOWING VIRUSES: Powers, Matulaitis, DeMole, Kine, McCarthy, Conn. 5, Ohio R, High Point, WS No. 4, EMC, and Col. SK. Pathologic alterations have been found in myocardium, lungs, liver, pancreas, thymus, brain and spinal cord, adipose tissue, and skeletal muscles. A comparison of the lesions produced by the individual strains has disclosed certain differential features which are discussed in detail. Within the group of so called Coxsackie viruses, myositis has not proved to be a constant finding, and it may occur in suckling mice infected with other types of virus.
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PMID:Lesions caused in suckling mice by certain viruses isolated from cases of so called non-paralytic poliomyelitis and of pleurodynia. 1542 85