Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54-year-old man with dermatomyositis initially responsive to corticosteroids and methotrexate developed severe myalgias, increasing weakness, and fevers. Laboratory studies were suggestive of disseminated histoplasmosis, and muscle biopsy revealed myositis, fasciitis, and yeast in the perimysial connective tissue. Histoplasma capsulatum was cultured from skeletal muscle. Despite antifungal therapy, necrotizing fasciitis progressed to gluteal abscess formation. Disseminated histoplasmosis may present atypically in immunocompromised hosts as fasciitis and myositis. Patients with dermatomyositis could be particularly vulnerable to soft tissue invasion by fungi due to their underlying microangiopathy.
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PMID:Disseminated histoplasmosis presenting as myositis and fasciitis in a patient with dermatomyositis. 773 41

Disseminated histoplasmosis is an AIDS-defining illness that can affect multiple organ systems. Myositis due to histoplasmosis is rare in HIV infected patients. We report here an HIV-infected patient who presented with myositis caused by Histoplasma capsulatum. Her HIV was under poor control and her CD4 cell count was only 11 cells/mm3. She responded well to treatment but later succumbed to another opportunistic infection. The literature on disseminated histoplasmosis is reviewed.
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PMID:HISTOPLASMOSIS MYOSITIS: A CASE REPORT AND LITERATURE REVIEW. 2686 94