Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathogenicity of a strain of Pasteurella gallinarum isolated in Fresno County, Calif., was compared with the American Type Culture Collection (ATCC) strain. Broiler chickens were inoculated intranasally with 10(7) colony-forming units (CFU) and intramuscularly with 10(5) CFU of each strain. The only notable lesions were in chickens inoculated intramuscularly with 10(5) CFU of the Fresno strain, which developed severe myositis at the inoculation site, pericarditis, perihepatitis, airsacculitis, and synovitis. P. gallinarum was reisolated from these lesions. Phenotypic characteristics of the two strains were identical except in reactions in ONPG broth and fermentation of xylose. Protein-banding patterns for the two strains were identical except for a single band difference in the 35-kilodalton region. Restriction endonuclease analysis confirmed that the Fresno strain was a distinct one. Plasmid analysis revealed that the ATCC strain had two plasmids and the Fresno strain had none.
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PMID:An atypical strain of Pasteurella gallinarum: pathogenic, phenotypic, and genotypic characteristics. 141

Patients with systemic lupus erythematosus (SLE) have a 25-50% chance of developing abnormal liver tests in their lifetime. This percentage does not include unconjugated hyperbilirubinaemia due to haemolysis associated with SLE, or elevated aspartate-aminotransferase caused by SLE-associated myositis. The most common cause is drug-induced hepatitis, while mild, predominantly lobular-but sometimes also portal and periportal-hepatitis reflecting SLE activity is another possibility. Other liver disease in SLE can be related to thrombotic events, whether or not associated with the lupus anticoagulant, including Budd-Chiari syndrome and veno-occlusive disease. Other liver abnormalities have been more or less frequently associated with SLE, such as nodular regenerative hyperplasia, perihepatitis, and hepatic or splenic rupture. Also viral hepatitis, obstructive jaundice, autoimmune hepatitis, primary biliary cirrhosis, granulomatous hepatitis, cryptococcus infection of the liver, chronic hepatitis with IgA or IgD deficiency, porphyria or idiopathic portal hypertension co-existing with SLE have been described.
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PMID:The spectrum of liver disease in systemic lupus erythematosus. 871 47

Gross and microscopic pathology caused by an atypical strain of Pasteurella gallinarum (Fresno strain) was compared in chickens with that caused by the American Type Culture Collection type strain. Ten 21-day-old broiler chickens were inoculated intranasally with 10(7) colony forming units or intramuscularly with 10(5) colony forming units of either strain. The birds were killed 7 days later, and gross and microscopic lesions were studied. Grossly, there was extensive white discoloration of pectoral muscles with mild fibrinous exudate in birds inoculated intramuscularly with the Fresno strain of P. gallinarum. Most of these birds also had severe fibrinous exudation over the heart, the capsule of the liver, the air sac, and in the hock joints. Microscopically, there was severe chronic pyogranulomatous airsacculitis, pericarditis, perihepatitis, myositis, synovitis, and granulomatous pneumonia. One bird had severe acute multifocal hepatitis. From this study, it is evident that the Fresno strain of P. gallinarum was more pathogenic than the American Type Culture Collection type strain when given intramuscularly.
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PMID:Pathology of an atypical strain of Pasteurella gallinarum infection in chickens. 1239 42