Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 21-month-old, castrated male Vizsla was presented for pelvic limb weakness, difficulty opening his mouth, ptyalism, voice change, and urinary incontinence. Myasthenia gravis and masticatory myositis were diagnosed. The unusual clinical findings, diagnosis, treatment, and case outcome are described, followed by a brief discussion of myasthenia gravis and masticatory myositis.
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PMID:Myasthenia gravis and masticatory muscle myositis in a dog. 1283 42

We report on a patient who underwent total vaginal hysterectomy for urinary incontinence 8 years previously with a sling operation using transobturator tape (TOT). She was admitted to our hospital after complaints of vaginal discharge, foul odor, and bleeding, left thigh pain, and edema. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a fistula tract from the vagina or urethra with remnant sling tape. We removed the remnant tape using intraoperative ultrasonography. This case exemplifies the rare occurrence of a vaginal fistula extending to the obturator, adductor, and pectineus muscles combined with myositis after TOT placement. It is important that urogynecologists recognize that TOT procedures may result in complications accompanied by common recurrent vaginal symptoms, such as vaginal odor and spotting, which can be identified by MRI or CT.
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PMID:Chronic vaginal discharge and left leg edema after a transobturator tape procedure. 2408 45

Immunotherapy has become a lifeline in cancer treatment. However, increasingly reports of programmed death-1 (PD-1) inhibitors have been linked to autoimmune disorders. We highlight two unique cases that presented with skeletal weakness and resulted in fatalities after developing de novo myasthenia gravis and myositis associated to immunotherapy treatment. Additionally, we describe the importance of early symptoms recognition and prompt treatment in preventing prolonged functional impairments and decreasing associated mortality. Patient 1: a 65-year-old male with a history of metastatic clear cell Renal Cell Cancer with metastasis to the lungs presented with unusual neck weakness, double vision, trouble breathing, and symptoms of urinary incontinence after his 4th cycle of nivolumab (480 mg every 4 weeks). He had a positive fatigability test, diplopia, and proximal weakness in bilateral upper extremities with an abnormal negative inspiratory force (NIF). Patient 2: a 83-year-old male with history of metastatic urothelial carcinoma presented with generalized weakness, difficulty holding his head up and swallowing three days after receiving the second cycle of immunotherapy treatment with nivolumab (480 mg every 4 weeks). He had proximal muscle weakness but normal sensation, fatigability tests and reflexes, very abnormally high creatine kinase (CK) greater than 4,000 ng/L, EMG results of myopathy and muscle biopsy showing focal perimysial chronic inflammatory cell infiltrates. Patient 1 ultimately died due to acute hemorrhage while patient 2 had a prolonged hospitalization and rehabilitation and ultimately discharged home with hospice. Prompt symptom recognition and treatment can potentially prevent prolonged impairment and mortality associated with cancer immunotherapy.
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PMID:Immunotherapy-related skeletal muscle weakness in cancer patients: a case series. 3257 96