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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was carried out on the pathology of trichinosis in human muscle biopsy sample and comparatively in experimental trichinosis in the rat, by current microscopic techniques and Troitsky's method of block silver impregnation of the nerve endings. Stress is laid upon the incipient changes in the parasitized muscle fibers, the sarcolemmic origin of the parasite capsule, the myogenic nature of certain periparasitary but intracapsular clear cells of precocious appearance and other associated, non-specific lesions, such as common myositis changes or giant myogenic foreign-body cells. The intimate relationships between parasitized muscle fibres, cellular interstitial reactions, local new-growth vessels and proliferation of the nerve endings are also described. The morpho-functional significance of such morphological synergic manifestations is discussed as an adaptation to the new local conditions brought about by the appearance of the peculiar muscle fibre-parasite unit in trichinosis.
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PMID:On skeletal muscle pathology in trichinosis. 15 Dec 21

A 35-year-old woman contracted severe trichinosis which was atypical in that it lacked a gastrointestinal prodrome and periorbital edema, and in that eosinophilia developed only late in the course of the illness. The patient developed an incapacitating myositis as well as complications of encephalopathy, myocarditis, and retinal hemorrhages, resulting in severe debilitation of more than two and one-half months' duration. Muscle histochemistry illustrated previously unreported features.
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PMID:Trichinosis: clinical report and histochemistry of muscle. 15 7

Since the introduction of the obligatory inspection of meat, trichinosis has become a very rare disease in Germany. Nevertheless, the possible occurrence of sporadical epidemies and isolated cases of trichinosis has to be kept in mind. During the last 30 years about 1300 cases of human trichinosis have been reported in Germany. The involvement of the central nervous system ranges from 6-24%; the symptoms may be caused by meningeal inflammation or/and a focal or generalized encephalitis. Myelitis is a very rare finding, some patients develop signs of peripheral neuropathy. During the acute stage pareses may be caused as well by myositis as by peripheral neuropathy. Various serological tests allow to confirm the diagnosis of trichinosis, but muscle biopsy is still the most informative piece of evidence leading to the diagnosis of trichinosis. Tiabendazole (trade name in Germany: Minzolum) is at present the drug of choice in the treatment of trichinosis; in addition good results have been found by corticosteroid therapy. Although most cases have a good prognosis, chronic sequelae may occur (for instance "rheumatic" pains in the muscles, loss of reflexes, convulsions and psychiatric distrubances).
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PMID:[Involvement of the nervous system in trichinosis (author's transl)]. 58 69

Musculature from 198 Canadian cattle with suspected lesions of eosinophilic myositis were examined histologically and by pepsin digestion. Sera from 51 of the 198 animals were also examined by enzyme-linked immunosorbent assay (ELISA) for anti-Trichinella antibodies. Viable larvae of Trichinella were not recovered from any of the cattle but one animal from Ontario tested positive for anti-Trichinella antibodies. Histologically, focal and/or diffuse eosinophilic myositis lesions were observed in 149 (75.2%) of the animals studied. Other conditions identified were sarcocystiosis, abscesses, cysticercosis, steatosis, fibrosis, granuloma, lymphosarcoma and necrosis. Sarcocystiosis was identified in 105 of the 198 animals in both normal and affected musculature. The study indicates that trichinosis is not a primary cause of eosinophilic myositis in cattle.
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PMID:Eosinophilic myositis in Canadian cattle. 188 89

Causes of the eosinophilia-myalgia syndrome other than L-tryptophan include parasitic myositis (that is, trichinosis), acute tropical myositis, sarcoidosis, granulomatous myositis, polymyositis, collagen vascular diseases, neoplastic myositis, and eosinophilic myositis. Some of these can be excluded by the absence of associated findings, that is, sarcoidosis, collagen vascular disease, neoplastic myositis; or on epidemiologic grounds, for example, acute tropical myositis. A muscle biopsy is diagnostic for trichinosis and for granulomatous, neoplastic, and eosinophilic myositis. A normal erythrocyte sedimentation rate militates against but does not rule out neoplastic or collagen vascular disease-associated myositis. The erythrocyte sedimentation rate may be elevated in most of these disorders although trichinosis is characterized by a very low rate. Most conditions associated with eosinophilia are characterized by both blood and local tissue eosinophilia.
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PMID:The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. 233 56

One hundred and fifty patients living in Salsomaggiore Terme developed signs and symptoms of trichinellosis after eating infected horse meat. The etiological agent was identified as Trichinella T3. This large outbreak gave us the opportunity of studying the rheumatic manifestations during this kind of parasitic disease. Myositis was observed in 62% of the entire series whereas arthralgias were recorded in only 20% of the patients. The muscle pain was described in several ways, but in the majority it appeared during isokinetic movements. The scapular girdle was involved much more than the pelvic girdle. Arthralgias correlated with the degree of myositis, thus allowing us to conclude that the involvement of the muscle groups proximal to the joint clearly determined a painful sensation in the joint itself. Our histopathologic data suggest that the eosinophils may play an important role in the myositis process.
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PMID:[Clinico-biological aspects of myositis due to Trichinella T3 with special regard to a rheumatologic study]. 263 29

Trichinosis is a worldwide disease contained by good husbandry and culinary practice, presenting unexpectedly in individual cases or mini-epidemics. The disease varies greatly in its manifestation and severity although when marked can be recognized by fever with myositis and periorbital oedema. Antibody tests are specific but the appearance on computed tomography of the brain are sufficiently characteristic to allow a confident diagnosis. Two cases where such appearances led to the diagnosis are reported.
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PMID:Trichinosis diagnosed by computed tomography. 324 11

Muscle biopsies were carried out on five patients affected by a chronic neuromuscular disorder, mostly in the form of a spinal muscle atrophy. All patients had suffered from acute trichinellosis many years before, the interval between acute parasitic infection and the appearance of the slowly progressive neuromuscular syndrome being of 21, 13, 35, 26 and 16 years respectively. In biopsy specimens, morphological and enzyme-histochemical changes typical of a progressive neurogenic muscular atrophy were present; in addition, encapsulated but still living, enzyme-positive parasites and signs of focal myositis were detected. The possible pathogenetic correlations between the "chronic" trichinellosis and the "degenerative" neuromuscular disorder are discussed.
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PMID:[Chronic trichinosis and neuromuscular diseases. Morphologic and pathogenetic aspects]. 686 Jan 14

In six males with chronic neurological signs who, 14-41 years previously, had an episode of acute trichinellosis cardinal symptoms were chronic muscle pain and lower-neuron damage. Other findings, probably related to trichinellosis, were episodes of pyrexia, chronic gastro-intestinal and cardiac symptoms, and in one case symptomatic epilepsy with psychomotor attacks. Significant laboratory findings were a chronic leukocytosis in one case, repeated elevations of eosinophil count in three. Muscle biopsy in all patients revealed live trichinella and (or) focal myositis. The serological findings did not correlate with the biopsy ones. If the live trichinae are encapsulated, antibody titres may be negative, while they may be markedly elevated when the trichinellae are dead. Whether encapsulated larvae can be influenced by tiabendazol or mebendazol is not clear from these observations.
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PMID:[Chronic trichinellosis and neuromuscular diseases: clinical, serological and therapeutic observations]. 711 59

A 38-year-old Japanese male who had traveled in China from September 13 to October 5, 1997, developed fever and severe conjunctivitis from October 20. After he was hospitalized in Kyoto City Hospital for persistent high fever on October 29, he developed muscular weakness and dysphagia which continued for two weeks. An electromyogram showed a myogenic pattern, and laboratory findings showed significant elevation of serum enzyme levels of muscle origin: CPK, 3,095 IU/l; aldorase, 195 IU/l; myoglobin, 7,570 ng/ml, and myoglobinuria, 94,700 ng/ml. The WBC was 10,800/microliter with 45% eosinophils. Muscular biopsy showed degeneration of muscle fibers with infiltration of macrophages and lymphocytes. On further inquiry, it was revealed that the patient had eaten smoked bear meat in China on September 30, three weeks prior to the onset of symptoms. A dot-ELISA serologic test for parasites was positive for Trichinella. Further, a coiled 1.2 mm long Trichinella larve was recovered from approximately 100 mg of frozen biopsied muscle by an enzyme digestion method. Mebendazole was given to the patient at a dosage of 200 mg/day for seven days. CPK levels were normalized within 3 days of the beginning of the treatment, and he was discharged without any symptoms. Physicians must be aware of trichinellosis and should include it in their differential diagnosis when examining patients with myositis and eosinophilia of unknown origin.
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PMID:[Imported trichinellosis with severe myositis--report of a case]. 1007 5


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