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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myositis ossificans is a localized, self-limiting, reparative lesion that is composed of reactive hypercellular fibrous tissue and bone. Although it is clearly a benign lesion, its clinical, radiological, and histological appearance may sometimes mimic a malignant tumor. Whether myositis ossificans represents a monoclonal or polyclonal hyperplastic proliferation is not yet known. To address this question, we therefore extracted DNA from the respective paraffin-embedded tumor tissues of nine women with a median age of 50 years at diagnosis (range: 20-84 years) and studied the X inactivation pattern by means of methylation-sensitive polymerase chain reaction and primers that target the polymorphic CGG trinucleotide repeat of the FMR1 gene. The fact that we did not detect any skewing of the X inactivation pattern in the five successfully analyzed cases corroborates the notion that myositis ossificans results from a polyclonal proliferation and confirms that it is a reactive, reparative process. Analysis of the X inactivation pattern may, thus, supplement the differential diagnostic work-up of cases with an uncertain histology, at least in the informative proportion of female patients.
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PMID:Evidence of a polyclonal nature of myositis ossificans. 1576 59

Myositis ossificans of the hand is extremely rare. We report an unusual case of myositis ossificans of the thenar muscles and discuss the diagnostic pitfalls whereby this condition can be mistaken for malignancy or infection.
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PMID:Myositis ossificans traumatica of the thenar region. 1608 31

Myositis ossificans traumatica is a pathological condition characterized by extraskeletal bone formation, induced by major or repeated minor trauma to the muscles. Our objective is to report an unusual case of myositis ossificans traumatica in a paraplegic patient. Bilateral swelling and erythema on the thighs of a 1-month paraplegic inpatient was diagnosed as myositis ossificans traumatica in the quadriceps muscles due to low-molecular-weight heparin injections for deep vein thrombosis prophylaxis. As a result, repeated injections under the spinal cord injury level should be avoided when possible because of the risk of myositis ossificans traumatica.
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PMID:Subcutaneous injections as a risk factor of myositis ossificans traumatica in spinal cord injury. 1729 27

Myositis ossificans is a reactive, ossifying process within soft tissues, which by its clinical and histological features is considered a pseudosarcomatous lesion. There are few reports that describe the cytologic findings in myositis ossificans, and each of these mentions different cellular composition. We describe the cytology of a case of myositis ossificans in a 14-year-old boy with clinical diagnosis of soft tissue sarcoma, and analyze the most common cytologic findings reported previously of this entity. We conclude that the different cellular composition reported, reflects the different histologic components of this lesion according to the area (zonation phenomenon), and that clinico-radiologic correlation is essential for the cytological diagnosis.
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PMID:Scrape cytology of myositis ossificans: report of a case and analysis of the cytologic findings described previously. 1806 93

Myositis ossificans (MO) is a reactive zonal fibroosseous lesion in skeletal muscle of the proximal extremities and trunk of young patients. It generally matures over several weeks to form a peripheral rim of bone. Fibroosseous pseudotumor of the digits (FOPD) is a similar reactive lesion of the digits, which is reportedly less well organized. Cases up to year 1980 were previously reported from our institution. We examined new cases of FOPD since 1980 and addressed the relationship of this lesion to both myositis ossificans and other distal extremity fibroosseous lesions. Fifty-two cases coded as FOPD or MO limited to the hands and feet, from 1980 to the present, were retrieved from our files. Nine cases were excluded due to incomplete material or rediagnosis as other lesion. Materials reviewed included radiologic images and pathologic material. Forty-three cases of FOPD were included. All cases were in the fingers, except for 1 toe case, with the proximal phalanx of the index finger the most commonly affected site. Duration of lesions was radiologically estimated to range from 2 to 6 weeks. Age of patients ranged from 10 to 64 years (mean and median of 40 years). Sixty percent of cases occurred in women. Morphologically, half of these lesions had a zonal organization, with mature woven bone peripherally and immature woven bone centrally; all bone demonstrated osteoblastic rimming. Clinically, 6 patients had known antecedent trauma, yet edema and pain of the digit were noted in all. Novel findings were that patients often had occupations requiring repetitive manual labor. Cases of FOPD were diagnosed and treated by simple excision. Three patients had residual disease, subsequently resected, without any recurrences. Fibroosseous pseudotumor of the digits is a distinctive, benign, reactive myofibroblastic and osseous zonal lesion that occurs in the finger of mainly adult patients, many with occupations that require repetitive manual use. Imaging can date these lesions, determine their exact location, and help with diagnosis. These lesions are the superficial and distal counterparts of MO. It is important to understand the morphology of FOPD to distinguish this type of lesion from other benign and malignant fibroosseous lesions.
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PMID:Fibroosseous [corrected] pseudotumor of the digit: a clinicopathologic study of 43 new cases. 1816 11

A 56-year-old healthy man noticed a stony-hard mass gradually grown in his neck for more than a 6-year period. Examinations revealed 2 additional calcified masses at the esophageal hiatus and retroperitoneum. The cut-surface of the operative specimens showed fibrous and mucinous appearance with many calcified islands. Microscopically, the lesion showed a gradual transform from the central immature area with fibroblasts and mucinous matrix, to the peripheral mature area with woven bone and osteoclasts (zoning phenomenon), which was compatible with the features of mature myositis ossificans. Myositis ossificans is an isolated, benign, nonneoplastic disease typically found in adolescence, after traumatic episode. Similar lesions have been found in the major musculature of patients with increased bleeding tendency. In the present case, idiopathic thrombocytopenic purpura was found to be associated and was suggested to be involved in initiating myositis ossificans. Still, it is extremely rare to observe lesions in these sites synchronously.
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PMID:Myositis ossificans associated with subclinical idiopathic thrombocytopenic purpura: report of a case. 1861 37

Myositis ossificans is a benign disorder of heterotopic bone formation occurring in response to soft tissue trauma. It most commonly presents in young adults and children as a painful, enlarging mass of the arm or thigh. Since there is frequently no significant history of injury, the lesion may be mistaken for a malignant bone or soft tissue tumor or infection. This article presents a case of a child in whom myositis ossificans presented with local signs and symptoms suggestive of a rapidly progressive compartment syndrome following trauma.
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PMID:Myositis ossificans mimicking compartment syndrome of the forearm. 1922 57

Myositis ossificans is a benign pseudosarcomatous bone-forming lesion, histologically characterized by 2 components: a spindle (myo)fibroblastic cell population and a bony component that is arranged in a "zonal" pattern. It mainly affects the deep soft tissues of limbs, but its occurrence in other unusual locations, such as abdomen, inside nerves, and the subcutaneous fat, has been reported. The existence of myositis ossificans restricted to the skin has rarely been published under the term "fibro-osseous lesion of the external auditory canal." Here, we describe an additional case in the external auditory canal, emphasizing its differential diagnosis and alerting dermatopathologists and pathologists to the possibility of encountering such lesion in this anatomic location. For purposes of unifying terms, we propose that cases similar to ours be called "cutaneous myositis ossificans" instead of fibro-osseous lesion of the external auditory canal.
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PMID:Cutaneous myositis ossificans: an appropriate descriptor for fibro-osseous lesion of the external auditory canal. 1931 4

Heterotopic ossification is defined as the formation of bone in sites where it does not normally exist. Myositis ossificans is classified as a type of heterotopic ossification, where bone formation occurs following soft tissue trauma. A case is presented of a 65-year-old female patient, diagnosed with maxillary and mandibular atrophy, in whom myositis ossificans developed secondary to iliac crest bone harvesting for preprosthetic augmentation prior to placement of maxillary and mandibular implants. Approximately 3 months after bone was harvested from the right anterior iliac crest, and despite a routine recovery from the bone grafting procedure, the patient developed persistent pain, described in her own words as "incapacitating," in the right lower quadrant of her abdomen. She was evaluated by a number of different specialists before a diagnosis of myositis ossificans was reached by her orthopedist. Management of the pain proved difficult, but eventually the symptoms improved to the extent that there was minimal disruption to her daily activities. Implant placement and prosthodontic treatment concluded to the patient's satisfaction. It may be advisable to include the possibility of occurrence of heterotopic ossification and resultant pain as a specific preoperative warning when iliac crest bone harvesting is planned to prepare patients for this potentially serious complication and to avoid litigation.
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PMID:Heterotopic ossification as a complication of iliac crest bone harvesting in a case of implant therapy. 1949 53

Myositis ossificans (MO) is characterized by abnormal heterotopic bone formation involving striated muscle, tendons, ligaments, fasciae, and aponeuroses. Myocardium, the diaphragm, tongue, larynx, smooth muscle, and sphincters are all spared. Several subtypes of myositis ossificans exist: posttraumatic myositis ossificans (PTMO), nontraumatic/pseudomalignant myositis ossificans, and myositis ossificans progressiva (MOP). This article reviews the clinical features and differential diagnoses of each subtype of MO and illustrates the typical imaging features demonstrated by plain radiography, ultrasound, radionuclide bone scans, computed tomography, and magnetic resonance imaging.
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PMID:The imaging of myositis ossificans. 2048 28


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