Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the five-year period 1964-68 1,335 patients were admitted to Mulago Hospital, Kampala, with tropical myositis. The marked increase in the number of admissions during the study period is attributed to a change in the utilization of the hospital rather than to a true increase in the incidence of the disease. There was found to be only slight variation in incidence between different age and sex groups and there was no convincing evidence that immigrants from high altitude areas, where the disease is rare, were at different risk. There was statistically significant month-to-month variation in admission rates but there was no apparent correlation with rainfall, and no marked seasonal variation. During the quinquennium there was a changing pattern of admission rates for patients from different counties, and some evidence of 'space-time' clustering. These findings are compatible with the primary muscle damage being induced by a virus or the presence of aberrant hookworm larvae, but an ingested toxin cannot be excluded. Trauma may also play a role in determining localization of the disease in some cases.
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PMID:The epidemiology of tropical myositis in the Mengo Districts of Uganda. 63 76

The New Zealand sea lion is a threatened species and two unusual events contributed to a decrease in recruitment in 2002. The first was a marked reduction (20%) in the number of pups born at the principal Auckland Island rookeries. Secondly, the mortality rate for pups was significantly elevated and was 33% by the end of February, almost three times the mean for that time of the year. Counts of females at rookeries indicated that the lowered fecundity was possibly due to a scarcity of food resources, supported by the fact that male pups (n=50) in 2002 grew poorly with the lightest recorded liveweights for the previous 8 years. Lowered fecundity may also have resulted from infection leading to foetal death, seen in an adult by-catch female, or abortion. Necropsies were conducted on 126/133 pups that died at Sandy Bay and for many the cause of death was multifactorial and included stillbirth, trauma, malnutrition, and severe anaemia caused by hookworm (Uncinaria spp) infection. An unusual disease presentation seen for the first time in 2002 was characterised by systemic bacterial infection that caused suppurative polyarthritis, severe necrotising fasciitis, myositis and osteomyelitis, suppurative peritonitis, pleuritis, or meningitis. For 41 pups, this syndrome was the primary cause of death and for an additional 16 it was a contributing factor along with hookworm infection or trauma. A consistent isolate has been Klebsiella pneumoniae with frequent isolations of Salmonella spp.
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PMID:New Zealand sea lion (Phocarctos hookeri) epidemic 2002 (abstract). 1603 96

Dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably, cutaneous larva migrans. Ancylostoma braziliense is most often implicated in dermatological lesions, and Ancylostoma caninum has been associated with eosinophilic enteritis and suggested as a possible cause of diffuse unilateral subacute neuroretinitis in humans. Other manifestations include eosinophilic pneumonitis, localized myositis, folliculitis, erythema multiforme, or ophthalmological manifestations. Ancylostoma eggs are morphologically indistinguishable, which complicates epidemiological studies. Surveys of dermatologists, gastroenterologists, and ophthalmologists would help to define the incidence of these zoonotic infections. Improved diagnostic tests are needed to identify the causative species involved and understand the epidemiology of hookworm disease. This review describes the discovery of the disease, the biology of the agents, and how that biology may impact disease.
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PMID:Hookworms of dogs and cats as agents of cutaneous larva migrans. 2018 54