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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors present a review on deep soft tissue infections--necrotizing fasciitis and necrotizing myositis, incl. the classification of myositis into sub-groups according to the causal agent. The authors describe the incidence of these diseases, basic clinical symptoms and therapeutic principles. Therapy is based on surgical treatment, antimicrobial treatment and in indicated cases on hyperbaric oxygen therapy (HBO).
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PMID:[Deep necrotizing soft tissue infections. Necrotizing fasciitis and necrotizing myositis]. 1253 2

Streptococcal myositis is a rare, often fatal, acute infection of the muscle, caused by an invasive group A beta-haemolytic streptococcus. It is characterised by muscle necrosis without abscess formation, and, in contrast to necrotising fasciitis, does not primarily affect the subcutaneous tissue or skin. A young adult male presented with streptococcal myositis initially affecting the rectus femoris muscle of his left thigh. The symptoms, signs and management are discussed. Particular emphasis is given to the benefits of emergency CT scans to diagnose and delineate the extent of the disease. These scans may need to be repeated if the disease progresses. The four cornerstones of management are: early diagnosis using emergency CT scans; high-dose intravenous antibiotics; early aggressive surgical debridement; and intensive fluid and nutritional support. Published by Elsevier Science Ltd. All rights reserved.
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PMID:Streptococcal myositis: a lesson. 1287 76

Neuromuscular syndromes following allogeneic bone marrow transplantation (BMT), although occasionally described,were not the focus of studies concerning neurologic complications following bone marrow transplantation. In this study,we summarize different polyneuropathy syndromes following BMT and report on patients with myasthenia gravis and inflammatory neuromuscular disorders such as myositis or fasciitis. Concerning the etiology of neuropathies, a neurotoxicity of immunosuppressants,a preexisting disorder due to the underlying disease as well as an association with graft-versus-host disease (GVHD) is discussed.GVHD-associated polyneuropathies as well as muscular complications have been found to occur during the early BMT phase, while myasthenia gravis is a late neurologic complication of GVHD.
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PMID:[Neuromuscular complications after allogeneic bone marrow transplantation]. 1259 17

Myofasciitis syndrome encompasses a group of disorders characterized by chronic inflammation and/or fibrosis of the subcutaneous septa and muscular fascia. We report on a patient in whom myositis was diagnosed in the areas previously irradiated for papillary thyroid carcinoma and anal canal carcinoma respectively 21 and 3 years after radiotherapy. We are not able to explain why myopathy developed at the same time in two different sites at a different interval from the two radiotherapic schemes. We can suppose that the patient developed a subclinical regional myopathy after the first radiotherapic scheme. Radiation induced heritable mutations within surviving cells that were unable to tolerate the second damage by systemic chemotherapy. It is unclear how radiosensitization correlates with an ability to reactivate latent effects in normal tissue. Physicians using chemotherapic radiosensitizers should be aware of their potential to induce a delayed form of radiosensitization. We report this case to encourage physicians to be alert to the knowledge of the clinical, histologic and morphologic characteristics of radiation myositis in order to distinguish it from an infectious or immune fasciitis or myositis.
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PMID:Chemotherapy-induced radiation recall myositis. 1288 14

A major role in imaging of the locomotor apparatus. Today, magnetic resonance imaging (MRI) has replaced invasive explorations such as arthrography or saccoradiculography. However, x-rays and scans must often be performed beforehand. Indisputable indications. MRI is crucial in affections of the spongy bone (tumours, osteonecrosis, algodystrophy, fatigue fractures.) and the soft parts (tumours, myositis, fasciitis.). Depending on the situation. The indications for MRI must be weighed versus a scan or arthro-scan in many situations. In the case of strong suspicion of an internal articular disorder, the arthro-scan currently more precise must be preferred. In cases in which there is little clinical orientation, the MRI is justified because of its capacity for global articular and abarticular exploration.
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PMID:[Magnetic resonance in osteoarticular exploration]. 1502 36

Invasive Group A Streptococcus (GAS) disease is a serious condition that has multiple manifestations. A particularly severe form of invasive GAS disease is necrotising fasciitis (NF). The case-fatality rate of GAS NF is approximately 20%. Penicillin remains the antibiotic of choice when treating invasive GAS infections. Epidemiological studies have shown that clindamycin is effective in the treatment of deep infections that are caused by GAS. Clinicians should consider adding clindamycin to the beta-lactam antibiotic regimen when NF or myositis is present. Intravenous immunoglobulin appears to be a promising adjunctive therapy in the management of GAS NF. Consultations with surgeons and infectious disease specialists are imperative.
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PMID:Treatment options in the management of necrotising fasciitis caused by Group A Streptococcus. 1526 84

Cervical necrotizing fasciitis is a serious, rapidly progressive infection along fascia planes that sometimes involves skin, subcutaneous tissue and muscle (myositis). The condition, often of dental or pharyngeal origin, is associated with high morbidity and mortality. Thirteen consecutive cases of cervical necrotizing fasciitis treated with hyperbaric oxygen at the Karolinska Hospital during the period 1997-2003 were reviewed. Eight male and five female patients, 33 to 78 years old, were treated according to the Karolinska Hospital guidelines for severe soft tissue infections. All patients recovered. Eleven of thirteen patients required intensive care and eight inotropic drugs. Streptococcus milleri was the predominant pathogen found in initial cultures. Three case reports are presented. Our findings lend further support to the literature on the importance of a prompt multidisciplinary approach with aggressive surgical intervention, broad-spectrum antibiotic therapy and hyperbaric oxygen therapy.
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PMID:[13 cases of cervical necrotizing fasciitis--all patients survived. Surgery, antibiotics and hyperbaric oxygenation give the best results]. 1529 12

The New Zealand sea lion is a threatened species and two unusual events contributed to a decrease in recruitment in 2002. The first was a marked reduction (20%) in the number of pups born at the principal Auckland Island rookeries. Secondly, the mortality rate for pups was significantly elevated and was 33% by the end of February, almost three times the mean for that time of the year. Counts of females at rookeries indicated that the lowered fecundity was possibly due to a scarcity of food resources, supported by the fact that male pups (n=50) in 2002 grew poorly with the lightest recorded liveweights for the previous 8 years. Lowered fecundity may also have resulted from infection leading to foetal death, seen in an adult by-catch female, or abortion. Necropsies were conducted on 126/133 pups that died at Sandy Bay and for many the cause of death was multifactorial and included stillbirth, trauma, malnutrition, and severe anaemia caused by hookworm (Uncinaria spp) infection. An unusual disease presentation seen for the first time in 2002 was characterised by systemic bacterial infection that caused suppurative polyarthritis, severe necrotising fasciitis, myositis and osteomyelitis, suppurative peritonitis, pleuritis, or meningitis. For 41 pups, this syndrome was the primary cause of death and for an additional 16 it was a contributing factor along with hookworm infection or trauma. A consistent isolate has been Klebsiella pneumoniae with frequent isolations of Salmonella spp.
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PMID:New Zealand sea lion (Phocarctos hookeri) epidemic 2002 (abstract). 1603 96

To determine the value of helical computed tomography (CT) in the diagnosis, management and outcome of patients suspected of having descending necrotizing mediastinitis (DNM). Thirty-two patients with suspected DNM were submitted to contrast-enhanced single detector-row helical CT, four detector-row CT and 16 detector-row CT of the neck and chest. In 10/32 patients (group 1) no abnormality was observed in the neck or in the chest spaces on CT scan. These patients were all treated non-operatively. In 12/32 patients (group 2) CT showed the presence in the neck spaces of fluid collections, fasciitis, cellulitis, myositis, jugular vein thrombosis and lymphadenopathy; in all these patients the chest was unaffected. A cervical drainage was performed in ten patients. In the remaining ten patients (group 3), the neck infection involved the mediastinal spaces in all the cases and the pleural and pericardial spaces; CT findings included mediastinal cellulitis and fluid collections, pleural and pericardial effusions, venous thrombosis and lymphadenopathy. In these patients, a cervico-mediastinal drainage was performed and antibiotics were administered. The CT provides a highly accurate depiction of the presence and the spread of DNM. The CT findings and the extension of disease are important factors in order to predict for patient management and outcome.
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PMID:Determining optimum management of descending necrotizing mediastinitis with CT; experience with 32 cases. 1613 21

Focal myositis is a localised inflammatory process affecting skeletal muscles belonging to the pathological group of inflammatory pseudo tumours of soft tissue that includes myositis ossificans, proliferative myositis and nodular pseudosarcomatous fasciitis. Very rarely, it may affect one of the neck muscles and present as a neck lump, in which case both the clinical and pathological picture can mimic a sarcoma. We describe a case of focal myositis of the sternocleidomastoid muscle, present a review of this rare condition and debate the necessity of biopsy.
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PMID:Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. 1636 67


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