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Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of granulomatous dermatitis with eosinophilla (Wells' syndrome) are reported. With Wells' original four cases, these two cases define a distinctive dermatosis with onset as cellulitis and formation of solid edema and either final spontaneous resolution or resolution with steroid therapy. Microscopic study showed diffuse tissue eosinophilia and fibrinoid flame figures, evolution of associated focal necrobiosis, and formation of focal microgranulomas associated with eosinophils. Biopsy of muscle and fascia showed comparable fasciitis and eosinophilic myositis. Immunofluorescence in one case disclosed fibrin in the dermis and lgM, lgA, and C3 in the blood vessels of the muscle. Recurrences of the lesions often appeared to be related to drug administration or surgery.
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PMID:Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. 44 39

Clostridial infections, putrid infections with aerobic and anerobic growing germs, air forced into the tissue during the primary trauma and the formation of gas by contact of the wound with aluminium, H2O2 and gasoline may be causes for the formation of gas and oedema in the tissues. Only infections with Clostridia are gas gangrene. We must differentiate the clostridial cellulitis from the clostridial myositis. Bacterioscopy allows a rapid differentiation to be made between putrid and clostridial infection. Beside intensive care and antibiotics, putrid infections demand an early extensive incision, for gas gangrene the radical excision of the damaged tissue is required. The effect of hyperbaric oxygenation is still under discussion. It can never replace surgical treatment.
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PMID:[Gas and oedema producing infections--today still a challenge (author's transl)]. 84 88

During an 8-year period, 30 patients with gas-producing infections were admitted for treatment of hyperbaric oxygen. Infection was a consequence of trauma and operation in 26 cases and a complication of other diseases in 4 cases. The definitive diagnoses were clostridial myositis in 12 cases, clostridial cellulitis in 7, non-clostridial cellulitis in 9 (mainly E. coli infections); in 2 cases the diagnoses were uncertain. Six cases of E. coli infection were misinterpreted as myositis and were treated with hyperbaric oxygen at 3 atm. abs. without effect. Five of these cases were cured by antibiotic therapy and surgical drainage. The risk of hyperbaric oxygen at 3 atm. abs. necessitates a strong indication for this kind of treatment. Thirteen cases of clostridial infections (2 with cellulitis, 11 with myositis) were successfully treated with hyperbaric oxygen except in 2 cases of myositis. Helpful data for the plausible diagnosis clostridial myositis in the acute stage were: a typical clinical picture with rapid progress of the local necrosis and inflammatory reaction, roentgenographically demonstrable intramuscular gas, and abundance of gram-positive rods in exudate from the inflammation. Laboratory data had a limited value. In some cases of clostridial myositis, a fall of hemoglobin to low values (less than 7.5 g%) was seen in the first 24 hours and high values of hemoglobin/plasma were noted in 4 cases. Incidents of side-effects from hyperbaric oxygen treatment were frequent but only a few were serious and these subsided during a short interruption of the treatment.
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PMID:Differential diagnosis and treatment of gas-producing infections. 110 64

The Wisconsin Division of Health (DOH) began surveillance for severe illnesses associated with group A beta-hemolytic streptococcus (GABS) infections in late 1989 to describe the current epidemiologic features and clinical spectrum of these infections in the state. Severe illness was defined by the isolation of GABS from the blood or by the development of one or more of the following in a patient infected with GABS: shock, extensive tissue injury, desquamating rash, disseminated intravascular coagulation, renal failure, adult respiratory distress syndrome, or death. Case reports involving 28 patients with severe GABS-related illnesses with onset from November 1989 through October 1990 were received by the DOH. The majority of the case-patients had sepsis (57%), cellulitis (50%) or both. Nine (32%) cases were fatal. Those who died were older than those who survived (median age 74 years v 43 years, p = 0.002) and were more likely to have clinical diagnoses that included pneumonia (relative risk [RR] 3.0, 95% confidence interval [CI] 1.2, 7.3) or necrotizing fasciitis/myositis (RR 3.7, 95% CI 1.5, 9.0). The median interval from illness onset to hospitalization was similar for fatal cases (1 day) and non-fatal cases (2 days), suggesting that early intervention after the appearance of clinical illness may not improve the outcome.
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PMID:Severe illness associated with group A-hemolytic streptococcal infections. 194 73

Prompt and early microbiological differential diagnosis is essential for clinical presumptive diagnosis of gas gangrene. The differential diagnosis includes clostridial myositis (gas gangrene), clostridial cellulitis and other gas producing infections. Examination of Gram preparation (bacterioscopy) and detection of the etiologic agent in muscle specimens are necessary for diagnosis. Clostridium perfringens has been shown as the causative organism of gas gangrene. A method is reported which allows the screening and identification of Clostridium perfringens from clinical specimens in a few hours. Using a medium yielding optimal growth and toxin production, pure cultures are centrifuged and subjected to rapid tests (detection of beta-galactosidase, phospholipase C).
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PMID:[Rapid diagnosis in Clostridium perfringens wound infections]. 255 53

Although the first Aeromonas strain was described by Zimmermann as early as in 1890, it took 60 years until Caselitz established human pathogenicity of strains then called "Vibrio jamaicensis". Since then, and especially in the last 10 years, there have been increasing numbers of reports on different infections caused by members of the genus Aeromonas. These include sepsis; meningitis; cellulitis; necrotizing fasciitis; ecthyma gangrenosum; pneumonia; peritonitis; conjunctivitis; corneal ulcer; endophthalmitis; osteomyelitis; suppurative arthritis; myositis; subphrenic abscess; liver abscess; cholecystitis and/or ascending cholangitis; urinary tract infection; endocarditis; ear, nose, and throat infections; balanitis; etc. The role of Aeromonas in gastrointestinal disease is very controversial. Increasing epidemiological data suggest that these organisms play a major role in enteric infections, but so far enteropathogenicity has not been demonstrable in experiments where volunteers were given high numbers of Aeromonas possessing different virulence factors. Virulence factors include hemolysin(s), enterotoxin(s), hemagglutinins, invasivity, and others; but these are not found more frequently in strains isolated from patients with diarrhea than from healthy controls. Whether there is a correlation between species and disease remains to be elucidated and requires more information about the taxonomy of this genus.
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PMID:Aeromonas as a human pathogen. 264 16

A survey of 584 veterinarians in equine practice was performed to determine their intramuscular injection techniques and the influence of those techniques on the development of clostridial myositis or cellulitis. Usable responses were obtained from 439 veterinarians (75.2%). Of these, 414 used a new needle and syringe for each injection, 241 swabbed the site with a cleansing/disinfectant agent, and 242 swabbed the top of multidose injection bottles with a similar solution. Only 2 clipped the hair at the injection site. Twenty eight of the respondents reported that at least 1 horse developed a clostridial infection at the injection site following 1 of their injections. None of the various injection techniques had a significant influence on the development of clostridial infection at the injection site.
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PMID:Intramuscular injection techniques and the development of clostridial myositis or cellulitis in horses. 319 40

V vulnificus is a halophilic or salt-requiring vibrio that has been isolated repeatedly from seawater and shellfish in coastal waters. This vibrio, first described by Hollis et al in 1976, can be differentiated from other similar vibrios by its ability to ferment lactose and by its lower tolerance for sodium chloride. V vulnificus, unlike most other vibrios, has seldom been incriminated as a cause of gastroenteritis but is a particularly virulent organism that causes severe wound infections in mostly healthy persons, or causes primary septicemia in persons with an underlying chronic disease, particularly chronic liver disease. Wound infections may range from relatively mild to severe and rapidly progressive cellulitis and myositis. Approximately 50% of patients with wound infections have some type of chronic underlying disease and the mortality rate is in the range of 15%. Wound infections are almost always associated with contact with seawater or the handling or cleaning of shellfish. Patients with primary septicemia have fever, chills, and prostration, and rapidly become hypotensive. Over 70% have distinctive bullous skin lesions that can strongly suggest the diagnosis in a patient with the appropriate history. The mortality rate is over 50%. There is a striking association between eating raw oysters and primary septicemia, with patients usually reporting having eaten raw oysters (or other shellfish) 24 to 48 hours before onset of symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Vibrio vulnificus. 366 22

Computerized tomography (CT) was performed in 19 patients with spinal cord injury (SCI) who had large pressure sores and in whom other complications were suspected. CT detected the depth, extent, and degree of undermining of the edges of the pressure sores in 19 of 27 lesions. Conventional radiography detected four cases of pelvic osteomyelitis. CT detected eight additional cases of pelvic osteomyelitis, as well as eight clinically unsuspected peripelvic and intrapelvic abscesses. Technetium-99m bone scanning was not very helpful because of localization in chronic proliferative changes of bone and widespread foci of myositis ossificans, as well as in osteomyelitis. Gallium-67 scanning detected only one of six abscesses. It was not very helpful because of confusion of abscess and osteomyelitis with intense soft tissue swelling and cellulitis, which are often associated with pressure sores in patients with chronic SCI. CT was found to be, by far, the modality of choice for detection of pelvic osteomyelitis and abscess in patients with SCI.
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PMID:Computerized tomography of pelvic osteomyelitis in patients with spinal cord injuries. 622 39

Altogether 26 cases of anaerobic infection (AI) of various etiology were analysed. Local tissue ischemia and operations on gastrointestinal organs in patients with secondary immunodeficit conditions are the factors facilitating the development of AI. The distinction is made between clostridial AI with a rapidly progressing gaseous gangrene and the non-clostridial AI with a slower course of a serous-purulent phlegmoma. Anaerobic myositis is observed in all forms of AI. Depending on the localisation of AI, anaerobic cellulitis and fasciitis are mentioned which occur mainly in non-clostridial AI. The treatment of AI and the mechanisms of death are discussed.
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PMID:[Comparative clinico-morphological characteristics of peace-time anaerobic infections]. 632 25


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