Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027121 (myositis)
 4,538 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have observed great alterations of the arrector pili muscle in a case of dermatomyositis. These alterations were as follows: diminution and then loss of the staining properties of the smooth muscle fibres, perinuclear vacuolization, great heterogeneity in the degeneration of fibres, elective involvement of the cyto-fibrillary system with integrity of the other constituents of the arrector muscle and the surrounding dermis. This smooth myositis is nonspecfic and similar to the one observed in other internal diseases (scleroderma, chronic alcoholism).
 ...
PMID:[Alterations of the arrector pili muscle in a case of dermatomyositis (author's transl)]. 93 32

Rhabdomyolysis can appear secondarily in the course of many different diseases, but also primarily as "idiopathic paroxysmal rhabdomyolysis" (i.p.r.), simulating clinically an acute myositis. Different factors can trigger this muscle reaction, the most important of them being physical stress, alcoholism, drug dependence, general anesthetics. In many of these cases biopsy investigations do disclose, out of rhabdomyolysis, a preexistent myopathy, usually dysmetabolic in origin, and often with familial incidence (lipid myopathies; carnitine palmityl-transferase deficiency; mitochondrial myopathies; glycogenoses; hypokaliaemia--but also central core diseases, tubular aggregates myopathy a.s.o.). Exact morphological and biochemical investigations are therefore needed in every case of i.p.r., with the purpose to identify the underlying myopathy in the patients and their relatives. Repeated controls of CPK values should be performed. Bearers of such subclinical myopathies have in fact to be considered patient at-risk if exposed to stress or if submitted to general anesthesia.
 ...
PMID:[Idiopathic paroxysmal rhabdomyolysis and clinically latent myopathy]. 664 96

In 1992, Lee and Opeskin published an article on the little-recognized problem of death related to multiple superficial soft-tissue injuries following an assault. These deaths resulted from an acute assault and were restricted to young aboriginal women with a history of alcoholism. Presented here is a similar case occurring in a 22-year-old Polynesian woman. However, there are some significant differences. Aside from the final acute assault, there was evidence of chronic repeated episodes of superficial soft-tissue injury that resulted in undermining of connections between large areas of different tissue planes. These injuries produced pockets and spaces lined by fibrous tissue and numerous old intramuscular and subcutaneous hematomas, some of which showed secondary infection. There was also dense soft-tissue and subcutaneous fibrosis, and myositis ossificans.
 ...
PMID:Superficial soft-tissue injury. 757 70

A 54 year old waiter was referred to the hospital because of proximal muscle weakness, most pronounced in his legs, which progressed to an inability to stand or walk within weeks. Myopathy was diagnosed based on the muscle biopsy findings and myositis was ruled out by laboratory and biopsy results. Further investigations led us to exclude an endocrine cause, hypovitaminosis D, infectious myopathy or a paraneoplastic syndrome. Heteroanamnesis revealed severe alcoholism, lasting for more than 30 years. The presumed alcohol induced hepatopathy was confirmed by liver biopsy. There were no signs of an acute alcoholic myopathy, as the weakness had developed rather insidiously, there was no elevation of the CK serum level nor myoglobinuria and a type 2 fibre atrophy was found by muscle biopsy. As expected the weakness improved under abstention. Thus the final diagnosis of a chronic alcohol induced myopathy was established.
 ...
PMID:[Immobilizing muscle weakness accentuated in leg and proximal muscles]. 962 35

We present a case of thoracic actinomycosis with hematogenous spread to the contralateral para-spinal muscles and ipsilateral lower extremity causing extensive myositis of the thigh. Aspiration secondary to chronic alcoholism and poor dentition were responsible for thoracic actinomycosis with subsequent hematogenous dissemination.
 ...
PMID:Disseminated actinomycosis with multifocal muscular involvement. 1702 63

Infectious muscle diseases have very different aetiologies. The viral myositides are proved by clinical and laboratory evidences in various etiologic settings (Influenza A and B, Coxsackie and HIV). The bacterial myositis was considered in the near past a tropical disease, but in our days with migration of people from South to North and the endemia of AIDS it became a problem of the "civilized" world. On the other hand, tuberculous endemia in Central-Eastern Europe, including Romania, results in quite high incidence of osteoarticular tuberculosis. In this section the authors take into consideration some clinical entities, such as psoas abscess, postanginal sepsis, beta-haemolytic streptococcus infection and that caused by Koch bacillus. Other rare musculoskeletal infections such as gas gangrene and non-clostridial anaerobic myonecrosis are also reviewed. Immune depression caused by underlying diseases, therapies, alcoholism or old age is often encountered. The parasitic aetiologies include infestations with Trichinella spiralis, Cysticercus cellulosae, Toxoplasma and Amoeba. The contribution of imagistic methods to diagnosis is emphasised. Ultrasonography associated with CT imaging are usually used, while MRI should be reserved for cases in which axial skeleton is involved. The management is based on appropriate antibiotic therapy and surgery.
 ...
PMID:Infectious muscle disease. 1723 94

Muscle compromise associated with diabetes includes muscle infarction, myositis, pyomyositis, and abscess formation. These conditions may also be seen in various other conditions, such as trauma, alcoholism, neoplasia, vasculopathy, HIV infection, and other immunocompromised states and hemoglobinopathies. Due to recent advances in imaging technology, these entities are readily detected and treated at an earlier stage. Different diagnostic modalities may be used, particularly magnetic resonance imaging (MRI), which is best for soft-tissue pathologies. Muscle infarction appears with acute edema and inflammatory changes on T1- and T2-weighted images, enhancing peripherally postcontrast, and nonenhancing central areas suggestive of necrosis, lacking focal fluid collections. The latter feature may help to exclude abscesses, as these mostly present with fluid collections. Pyomyositis in its early period demonstrates ill-defined muscle enlargement with increased signal on T2-weighted images. Myositis shows no signal changes or mild hypointensity on T1-weighted images, but diffuse hyperintensity on T2-weighted images, with no or minimal enhancement following intravenous contrast media. Recognition of these pathologies is important, since management approaches vary depending on the etiology of the muscle involvement and overall status of the patient.
 ...
PMID:Muscle compromise in diabetes. 1856 60