Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied segmental spinal myoclonus of abdominal muscles observed in a 62-year-old man. The myoclonus consisted of continuous rhythmic contractions of the bilateral abdominal muscles at T8-T10 segments at a rate of 3 to 4 c/s. It was observed with the patient was in supine position and almost exclusively during the expiratory phase, and it disappeared during sleep. The myoclonus decreased in amplitude or disappeared during physical exercise, and intensified for a few minutes after physical exercise including breath-holding by Valsalva's maneuver. Myelography showed spinal vascular malformation at the level of T9-T11 vertebrae. Electromyography showed neurogenic change of the paravertebral muscles at T5-T11 segments on the right side and T7-T9 segments on the left side. Hypoalgesic zone contained those segments. The myoclonus disappeared for a short period after lumbar puncture and improved by administration of clonazepam.
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PMID:[Myoclonus of the abdominal muscles originated in spinal vascular malformation]. 214 Sep 64

We report the case of a 77-year-old woman with a two-year history of abdominal non rhythmic myoclonus. Neurological examination was normal. Bursts of myoclonic activity were recorded from the rectus abdominis muscle and then from the external oblique muscle after a delay of 40 ms. Magnetic resonance imaging of dorsal spine revealed T7-T8 and T9-T10 disc protrusions without root compression. Electroencephalography, back-averaging-EEG, brain computed tomography scan, motor and sensory evoked potentials revealed no abnormality, thus ruling out the possibility that the myoclonic jerks might be of cortical origin. Electromyography of the rectus abdominis and external oblique and of the T7-T8 paraspinal muscles did not show signs of denervation. Therefore a peripheral origin of the myoclonus could be excluded. In our patient the difference in latency of the EMG activity between the external oblique and the rectus abdominis muscles was possibly due to the caudal propagation of the myoclonus by slowly conducting pathways, supporting the hypothesis for its propriospinal origin, even though a known ethiologic factor could not be identified.
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PMID:[Abdominal propriospinal myoclonus of unknown etiology]. 767 60

We report the case of a 75-year-old woman who developed involuntary jerks of the abdominal musculature. They occurred spontaneously or triggered by a forced inspiration or attempts to rise from the supine position. Electromyography (EMG) recorded abnormal bursts of muscle activity in the abdominal, thoracic paraspinal, and intercostal muscles up to the 3rd intercostal space. The bursts were bilateral, arrythmic and synchronous in all muscles. Magnetic resonance imaging (MRI) of the spine revealed a syringomyelic cavity between the T3 and T10 levels. The topological correlation between the EMG muscle activities and the MRI findings was consistent with spinal myoclonus arising from the thoracic spinal cord. The synchronous bursts in muscles depending from few adjacent spinal segments suggested the diagnosis of segmental spinal myoclonus (SSM). There are few reports of SSM related to syringomyelia in the literature.
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PMID:Segmental spinal myoclonus and syringomyelia: A case report. 1677 36