Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the effect of apomorphine, a dopamine receptor agonist, on epileptic photosensitivity in 7 patients with progressive myoclonus epilepsy (PME). Specific diagnoses included Baltic PME (Unverricht-Lundborg disease), Lafora disease, Kufs' disease, juvenile neuroaxonal dystrophy, and action myoclonus-renal failure syndrome; 2 patients had PME of uncertain etiology. Apomorphine blocked the epileptic photosensitivity in all patients and also reduced intention myoclonus in a patient with Baltic PME. There is a common deficit of dopaminergic inhibitory neurotransmission at the level of the striate cortex in patients with PME, regardless of the nature of the specific underlying neuropathologic process.
 ...
PMID:Common dopaminergic mechanism for epileptic photosensitivity in progressive myoclonus epilepsies. 190 98

Rats injected intrastriatally with picrotoxin and carbachol showed sustained myoclonic jerks of the contralateral forelimb. The role of acetylcholine and dopamine in picrotoxin myoclonus was examined by measuring the effects of intrastriatal pharmacological agents on the frequency and intensity of the jerks. Atropine and hemicholinium-3, which reduce acetylcholine function, antagonized the myoclonus. Apomorphine, which has been shown to reduce striatal dopamine function via "autoreceptors", potentiated the jerking, whereas D-amphetamine antagonized the myoclonus. The findings are discussed in relation to proposed interconnections of striatal neurones.
 ...
PMID:Role of acetylcholine and dopamine in myoclonus induced by intrastriatal picrotoxin. 707 34