Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Frontal kindling in rabbits, prolongation of the duration of afterdischarge concomitant and clinical manifestations and the epileptic foci (primary and independent secondary foci) were revealed. Auditory and visual evoked responses were recorded after completion of the kindling phenomenon. 1. Electrical stimulations, 300 microA, 60 Hz. 1 msec in duration, 2 sec train, were applied once a day. Clinical manifestations were divided into five stages: 1) the arrest of behavior or no response, 2) the adversive movement with a tonic and/or clonic convulsion of left paw, 3) the adversive movement following mastication, facial spasms and postictal stupor, 4) falling down abruptly and generalized convulsive seizure, and 5) generalized seizure followed by rotatory movement, vocalization and myoclonus. The appearance of five generalized convulsions was defined as a completion of the kindling phenomenon. 2. The duration of afterdischarge increased stepwisely from 2--3 sec to more than 400 sec. However, there was no constant duration of AD even though the animal showed generalized convulsion after completion of the kindling phenomenon. 3. Visual and auditory evoked responses were recorded after completion of kindling. There was a change in the auditory evoked response but not in the visual. A shortening of the latency of P2 component (73.3 msec in peak latency), N2 component (146.7 msec in peak latency) and amplification of the amplitude of N2 component were noticed. Thus, the intermittent weak electrical stimulation on the frontal cortex in rabbits induced generalized convulsion and produced primary and independent secondary epileptic focus on EEG, and the change of auditory evoked response was recognized in kindled animals.
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PMID:Frontal kindling in rabbits and its influence on visual and auditory evoked response. 53 39

Frontal and parietal components of somatosensory evoked potentials (SEPs) following median nerve stimulation and scalp potentials preceding myoclonic jerks (jerk-locked averaging, JLA) were compared in 6 patients with cortical reflex myoclonus. Giant potentials were found over the parietal cortex in both conditions. Prominent frontal activity was detected following median nerve stimulation which, however, was absent in jerk-locked averages. Therefore an identical generator of the giant SEP and the JLA is unlikely. As the frontal component is lacking in jerk-locked averaging, the spontaneous jerks produced in our experimental paradigm are believed to be due to spontaneous hyperactivity of the parietal cortex rather than to pathologically enhanced transcortical reflexes.
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PMID:Differences of cortical activation in spontaneous and reflex myoclonias. 171 44

Fifty-two patients having suffered 60 episodes of non convulsive Status Epilepticus (SE) proven by electroencephalography between 1976 and 1986 are reported. According to electroclinical criteria, these SE were classified into three groups: Petit Mal Status (PM St), Psychomotor Status (Ps M St) and Frontal Polar Status (F St). The exact diagnosis could not be accurately established by the clinical examination alone. It required the analysis of the ictal EEG. However, some clinical signs might suggest the correct diagnosis. Thus, a fluctuating confusional state associated with myoclonus suggested a PM St. A state of confusion with alteration of the emotional sphere evoked especially a Ps M St. A confusional state associated with behavioural disorders of euphoric type and to programmation difficulties was seen mainly in F St.
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PMID:[Confusional states of epileptic origin. Value of emergency EEG]. 318 98

Two patients with epilepsy and large hemispheric lesions underwent section of the frontal fibres of the corpus callosum for the treatment of seizures refractory to medical treatment. A severely retarded girl of 18 had encephalotrigeminal angiomatosis (Sturge-Weber syndrome) with multiple daily absences, tonic-clonic, myoclonic, atonic and adversive seizures since infancy. All types of fits--with the exception of adversive seizures and rare tonic-clonic fits--disappeared after anterior callosotomy. Another moderately retarded girl of 18 had an old cystic lesion over the entire territory of the left middle cerebral artery. She had had right hemiplegia since infancy and frequent brief absences and massive myoclonus triggered by unexpected sensory stimuli since the age of six years. Following anterior callosotomy there was an almost complete disappearance of the absences and a marked reduction of her startle myoclonus. Frontal callosotomy is a useful procedure in epileptics with large hemispheric lesions and carries less risk than hemispherectomy or total commissurotomy.
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PMID:Anterior callosotomy as a substitute for hemispherectomy. 693 7