Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027066 (
myoclonus
)
4,275
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report the case of a 72-y-old man with concomitant autoimmune encephalitis and
severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. The patient presented with subacute cerebellar syndrome and
myoclonus
several days after general infectious symptoms began.
Methods:
Clinical examination, CT, PET, MRI, and autoantibody testing were performed.
Results:
The oropharyngeal swab test was positive for
SARS
-CoV-2. The brain MRI results were normal. Cerebrospinal fluid testing showed normal cell counts, a negative result on reverse-transcription polymerase chain reaction testing, and no oligoclonal banding. Brain
18
F-FDG PET showed diffuse cortical hypometabolism associated with putaminal and cerebellum hypermetabolism, compatible with encephalitis and especially cerebellitis. The immunologic study revealed high titers of IgG autoantibodies in serum and cerebrospinal fluid directed against the nuclei of Purkinje cells, striatal neurons, and hippocampal neurons. Whole-body
18
F-FDG PET and CT scans did not show neoplasia. Treatment with steroids allowed a rapid improvement in symptoms.
Conclusion:
This clinical case argues for a possible relationship between
SARS
-CoV-2 infection and autoimmune encephalitis and for the use of
18
F-FDG PET in such a context.
...
PMID:Autoimmune Encephalitis Concomitant with SARS-CoV-2 Infection: Insight from
18
F-FDG PET Imaging and Neuronal Autoantibodies. 3270 34
A wide range of neurological signs and symptoms have been associated with
SARS
-CoV-2 infection. In the present report, we described two Italian patients diagnosed with diaphragmatic
myoclonus
after COVID-19. In both cases, mild lymphocytosis at cerebrospinal fluid analysis and no structural brain changes were reported. The pathophysiological origin of the
myoclonus
in the two cases was different. In case 1, electroencephalogram did not reveal any cortical correlates and brain imaging of the spine was unremarkable, while in case 2, cortical origin of
myoclonus
was demonstrated. With the present two cases, we confirm and extend the neurological manifestations of
SARS
-CoV-2 infection.
...
PMID:Diaphragmatic myoclonus due to SARS-CoV-2 infection. 3309 Mar 3
