Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electroencephalogram (EEG), brain stem auditory-evoked potential, and flash visual-evoked potential recordings were taken from healthy sheep and from 3 sheep with scrapie, a CNS slow virus infection. The EEG changes included semi-periodic, polyphasic, high-voltage sharp waves (bilaterally synchronous and symmetric in all channels), and a cyclic alternating pattern consisting of a high-voltage low-frequency phase, followed by a low-voltage high-frequency phase. The high-voltage phase occurred with increased arousal, and the low-voltage phase occurred with decreased arousal. Myoclonic jerks were coincident with EEG sharp waves in one sheep with scrapie. Several spontaneous focal seizures were observed. Wave-form amplitudes were greatly reduced in the brain stem auditory-evoked potential and flash visual-evoked potential; degree of reduction did not always correlate with disease severity. The EEG and evoked potential changes were seen in an exposed sheep that had not yet developed clinical signs of scrapie.
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PMID:Electroencephalogram and evoked potentials in naturally occurring scrapie in sheep. 396 85

Twenty three patients are described with a Kojewnikow syndrome in order to identify possible etiological factors. According to their history, clinical and E.E.G. features, patients could be classified into two groups; 1) Eleven patients corresponded to the classical description of the Kojewnikow syndrome: variable age at onset of the disease, rare somatomotor seizures, delay of onset of myoclonic jerks often of long duration, myoclonus limited to a small region, normal neurological examination, stable hemiplegia, normal results of psychometric tests, localised E.E.G. alterations. In most of these patients the etiology of the disorder was known, and the symptoms could be related to a localised lesion of the central cortex; 2) the second group (11 patients) presented with completely different characteristics: early onset of fits (age: 2 to 10 years), presence of other seizure types, short delay of onset of myoclonic jerks, high frequency of seizures, localization of myoclonus over large parts of the body, progressive evolution of a motor syndrome, associated neurological signs and disorders of sleep and behavior, progressive mental deterioration, characteristic E.E.G. pattern with long subclinical paroxysms of slow spikes (sharp waves) with variable localization, diffuse cerebral lesions of unknown etiology were found. Only one patient could not be allocated to either group. Several circumstantial data suggest that patients of the second group may suffer from a slow virus infection. Should this hypothesis be confirmed, a reconsideration of the Kojewnikow syndrome from the etiological standpoint would be of great theoretical and practical interest.
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PMID:[Continuous partial epilepsy: syndrome and disease]. 682 Jan 77