Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Canine distemper myoclonus was electromyographically analysed to throw more light upon the condition without invasive surgical intervention. Although myoclonus seemed to occur synchronously in many muscles, the onset of myoclonus appeared to be slightly earlier in one or two particular muscles and, furthermore, myoclonus did not arise temporally in descending or ascending order along the neuroaxis. Myoclonus-like discharges were evoked by tendon-tapping and this feature disappeared after cessation of myoclonus. In successive myoclonic bursts, a significant positive correlation was noted between the silent period and the subsequent discharge period, independently of the level of consciousness, i.e., the longer the silent period, the longer the subsequent episode of myoclonus. This correlation was re-established very early after recovery from anesthesia with halothane, when electroencephalograms showed slow waves. These results strongly indicate that the lower motor neurons may be the primary site responsible for the genesis of canine distemper myoclonus.
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PMID:Electromyographic analysis of canine distemper myoclonus. 268 52

Canine distemper virus (CDV) is thought to have caused several fatal epidemics in canids within the Serengeti-Mara ecosystem of East Africa, affecting silver-backed jackals (Canis mesomelas) and bat-eared foxes (Otocyon megalotis) in 1978 (ref. 1), and African wild dogs (Lycaon pictus) in 1991 (refs 2, 3). The large, closely monitored Serengeti lion population was not affected in these epidemics. However, an epidemic caused by a morbillivirus closely related to CDV emerged abruptly in the lion population of the Serengeti National Park, Tanzania, in early 1994, resulting in fatal neurological disease characterized by grand mal seizures and myoclonus; the lions that died had encephalitis and pneumonia. Here we report the identification of CDV from these lions, and the close phylogenetic relationship between CDV isolates from lions and domestic dogs. By August 1994, 85% of the Serengeti lion population had anti-CDV antibodies, and the epidemic spread north to lions in the Maasai Mara National reserve, Kenya, and uncounted hyaenas, bat-eared foxes, and leopards were also affected.
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PMID:A canine distemper virus epidemic in Serengeti lions (Panthera leo). 855 43