Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027066 (myoclonus)
 4,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The disorders of ocular motility seen in association with brainstem or cerebellar disorders may point to rather specific anatomical or pathological correlations. Pontine gaze palsy reflects involvement of the pontine paramedian reticular formation. Internuclear ophthalmoplegia signifies a lesion in the medial longitudinal fasciculus. Skew deviation may result from a lesion anywhere in the posterior fossa. Ocular bobbing typically results from a pontine lesion. The Sylvian aqueduct syndrome is characteristic of involvement in the upper midbrain-pretectal region, usually a pinealoma. Cerebellar lesions may be manifested by gaze paresis, skew deviation, disturbances of saccadic or smooth pursuit movements, ocular myoclonus, or several characteristic forms of nystagmus. Familiarity with these disorders may be of great help to the physician dealing with a patient with a possible posterior fossa lesion.
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PMID:Abnormal ocular motility with brainstem and cerebellar disorders. 34 6

We report clinical features of ocular symptoms in 80 patients with multiple sclerosis (MS). Serial 80 patients with MS had been admitted to our Neurology Ward at Nihon University Itabashi Hospital from April 1980 to October 2003. All patients were also examined by our neuro-ophthalmologists. Ocular symptoms were observed in 49 patients, and 14 patients were male and 35 were female. Patients' age at onset varied from 17 to 51 years old, with the average being 31.2 +/- 4.2 years. Observation period were 6 months to15 years, and average 5.4 +/- 1.4 years. In visual symptoms, retrobulbar optic neuritis was observed in 33 eyes of 26 patients. On the first attack of retrobulbar optic neuritis, 25 eyes showed a corrected visual acuity of less than 0.1. After corticosteroid therapy, a corrected visual acuity improved more than 1.0 in 17 eyes. Optic atrophy was observed in 22 eyes and color blindness in 16 eyes. On the second attack of retrobulbar optic neuritis on the same eyes, 6 of 9 eyes showed a corrected visual acuity of less than 0.1 after corticosteroid therapy. Optic atrophy and color blindness were confirmed in all eyes. Homonymous hemianopia was detected in 2 female patients and completely resolved after corticosteroid therapy. On the other hand, ocular motor symptoms were observed in 29 patients. Internuclear ophthalmoplegia was detected in 18 patients, nystagmus in 5, abducens nerve palsy in 5, skew deviation in 5, one-and-a-half syndrome in 2, gaze palsy in 2 and ocular myoclonus in 1. In all except one patient with primary position downbeat nystagmus, ocular myoclonus and bilateral internuclear ophthalmoplegia, these symptoms improved completely within 8 weeks after corticosteroid therapy. We emphasize that cooperation of neurologist and ophthalmologist plays an important role for clinical evaluation of MS patients.
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PMID:[A neuro-ophthalmological analysis in 80 cases of multiple sclerosis]. 1547 Oct 86