Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026986 (myelodysplastic syndrome)
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Human Gene/Protein
MLF1IP protein 11.1
FAM160B2 11.1
140 AA 11.1
C5orf4 11.1
ZBTB38 protein 11.1
PP2135 11.1
EMID1 11.1
C5orf3 11.1
granzyme B variant 11.1
HDACL1 11.1
OR51D1 11.1
HSPA9 protein 11.1
U2 small nuclear RNA auxiliary factor 1 11.1
MDS 11.1
C6orf80 11.1
KIP 2 11.1
C9orf43 11.1
phosphoprotein regulated by mitogenic pathways 11.1
RARS 10.9
ZRSR2 10.7
ASXL1 protein 10.4
additional sex combs like 1 10.4
LUC7L2 10.3
PURG-A 10.1
chemokine (C-C motif) receptor 4 10.1
ankyrin repeat domain-containing protein 26 10.1
teashirt zinc finger homeobox 2 10.1
HLA class II DRB1 antigen 10.1
Dedicator of cytokinesis 4 10.1
MLL-MAML2 10.1
WD repeat and FYVE domain containing 3 10.1
H4FN 10.1
ALL1-fused gene from chromosome 1q 10.1
U2AF1 10.0
SET binding protein 1 9.9
SAMD9L 9.9
GSD1b 9.7
myeloid leukemia factor 1 9.6
SF3B1 9.6
AML1/MDS1 9.6
ASXL1 9.5
MNDA protein 9.5
AP2 associated kinase 1 9.5
ZNF183 9.5
PRPF40B 9.5
SETBP1 protein 9.5
ankyrin repeat domain 28 9.5
EFHB 9.5
MLF1IP 9.5
SAMD9 9.5
ORC5L 9.5
KIAA1546 9.5
MOZ/CBP 9.5
LNP1 9.5
RPS14 9.4
ETV6 protein 9.3
MDS1 9.2
CSNK1A1 9.2
DDX41 9.2
MLF1 9.1
AKT3 protein 9.1
RPN1 9.1
CCDC12 9.1
sterile alpha motif domain containing 9 9.1
NKIAMRE 9.1
C10orf10 9.1
HSP105B 9.1
ZC3H15 9.1
ZNF333 9.1
ZNF140 9.1
ACPL 9.1
NAP1L2 9.1
PTPLAD2 9.1
SLC25A39 9.1
EVI-1 9.0
GATA2 protein 8.9
EVI1 8.9
BCORL1 8.9
ANKRD26 8.9
DDX42 8.9
more...
Disease
myelodysplastic syndrome 11.1
Myeloblastic leukemia with maturation 11.1
MDS-U 11.1
5q minus myelodysplastic syndrome 11.1
Preleukemia 11.1
Refractory anemia with excess blasts-2 11.1
Myelodysplastic Syndrome 11.1
Leukemia secondary 11.1
MLSM7 11.1
RCMD-RS 11.1
refractory cytopenia with multilineage dysplasia 11.0
MDS 10.9
RAEB-1 10.9
RAEB-2 10.9
AML/MDS 10.9
ATMDS 10.9
de novo myelodysplastic syndromes 10.9
RARS 10.9
RAEB 10.8
RAEB-T 10.8
Therapy-related myelodysplastic syndrome 10.8
Acquired sideroblastic anemia 10.6
Marrow dysplasia 10.6
MDS/MPD 10.6
refractory anemia 10.5
secondary myelodysplastic syndromes 10.5
MDS/MPD-U 10.5
sideroblastosis 10.3
chronic myelomonocytic leukemia 10.1
Megakaryocytic hypoplasia 10.1
FAB type M5a 10.1
runner's anemia 10.1
Oral papillomatosis 10.1
Acute myeloid leukemia with multilineage dysplasia 10.1
Other anaemias 10.1
CMML-2 9.8
ataxia-pancytopenia syndrome 9.7
secondary AML 9.7
atypical chronic myeloid leukemia 9.6
FPD/AML 9.5
Cardiac siderosis 9.5
Malignant mastocytosis 9.5
XLN 9.5
Monosomy 7 syndrome 9.5
untreated adult AML 9.5
trisomy 8 9.3
panmyelosis 9.1
Acquired aplastic anemia 9.1
myelodysplastic anemia 9.1
Therapy-related acute myeloid leukemia and myelodysplastic syndrome 9.1
Erythroid hyperplasia 9.1
Candidal meningitis 9.1
Paraneoplastic vasculitis 9.1
Secondary hemochromatosis 9.1
bone marrow disorder 9.0
Pelger-Huet 8.9
AML progression 8.9
CMML-1 8.9
Eosinophilic leukemia 8.9
IVIC syndrome 8.7
Neutrophilic panniculitis 8.7
Spindle cell liposarcoma 8.7
Secondary thrombocytopenia 8.7
juvenile myelomonocytic leukemia 8.7
trisomy 1q 8.7
sideroblastic anemia 8.6
Secondary anemia 8.6
Polyserositis 8.6
MAR 8.5
severe congenital neutropenia 8.5
Pulmonary mycosis 8.5
Seronegative arthritis 8.5
monosomy 16q 8.5
Erythroid hypoplasia 8.5
Tumor flare 8.5
monosomy 7q 8.4
Neutrophilic dermatosis 8.4
acute myeloid leukemia 8.4
chronic myeloproliferative disorders 8.3
acute nonlymphocytic leukemia 8.3
more...
Symptom
swollen penis 7.7
diminished hearing 5.9
ENT symptoms 5.6
motor symptom 5.5
Rest tremor 5.3
polymyalgia 5.2
splenomegaly 4.7
Hyperekplexia 4.7
stuffy nose 4.6
Spotting 4.6
pachyonychia 4.5
bone pain 4.4
hepatosplenomegaly 4.3
dark urine 3.9
bradykinesia 3.9
night sweats 3.8
fever of unknown origin 3.7
rigors 3.7
Neurologic symptoms 3.5
pallor 3.5
bradypnea 3.4
ACHE 3.2
lightheadedness 3.1
non-productive cough 2.9
lassitude 2.9
Stepping 2.8
autodigestion 2.8
No adverse effect 2.7
enuresis 2.7
leg edema 2.7
dry skin 2.7
exertional dyspnea 2.6
right upper quadrant pain 2.6
chills 2.6
hangover 2.6
nausea 2.5
shortness of breath 2.5
fatigue 2.5
nasal congestion 2.5
asthenia 2.5
hepatomegaly 2.5
decreased appetite 2.5
abdominal fullness 2.4
consciousness disturbance 2.4
constipation 2.3
polyuria 2.3
erythema 2.2
orthopnea 2.2
arthralgia 2.2
myalgia 2.1
anorexia 2.1
lethargy 2.0
dyspnea 2.0
polydipsia 1.9
personality change 1.9
nausea and vomiting 1.9
hypoproteinemia 1.9
Gastrointestinal symptoms 1.9
dysuria 1.8
Ill 1.8
atypical chest pain 1.7
diarrhea 1.7
thigh pain 1.7
drooling 1.7
limb pain 1.7
forgetfulness 1.7
vomiting 1.7
apathy 1.6
paraparesis 1.6
cough 1.6
exhaustion 1.5
intestinal bleeding 1.4
cachexia 1.4
sleepiness 1.3
livedo 1.3
abdominal discomfort 1.3
tremor 1.3
dizziness 1.3
abdominal pain 1.3
hip pain 1.2
more...
Drug
MDS 11.1
Dacogen 10.6
Starasid 10.1
Azacytidine 9.4
Tandutinib 9.3
Revlimid 9.2
Lenalidomide 9.1
Deferasirox 8.7
Sobuzoxane 8.5
Busulfex 8.3
Ranimustine 8.3
Clofarabine 8.2
Lonafarnib 8.2
Tipifarnib 8.1
Rubitecan 8.1
Zemplar 7.5
Ilmofosine 7.4
Alvocidib 7.3
Amifostine 7.2
Roquinimex 7.2
Ethyol 7.1
Midostaurin 7.1
Antithymocyte globulin 7.1
anti-CD33 7.1
Vitamin K2 7.0
Fludarabine 6.9
Posaconazole 6.9
Bexxar 6.9
TRM 6.8
CFPM 6.7
Roferon A 6.7
ARA-C 6.7
Forodesine 6.5
Zebularine 6.5
TEL 6.4
Lenograstim 6.3
Epoetin 6.3
Istradefylline 6.3
G-CSF 6.3
Ambisome 6.3
Sodium phenylbutyrate 6.3
Idarubicin 6.2
Irofulven 6.1
Nelarabine 6.1
Zevalin 6.1
Exelon 6.0
AraC 5.8
Epoetin alfa 5.7
Exelon 5.7
Darbepoetin alfa 5.7
Interferon alfa-2a 5.7
Leukine 5.6
Rocaltrol 5.6
Filgrastim 5.4
Filgrastim 5.4
Epoetin alfa 5.4
Aclarubicin 5.3
OctreoScan 5.1
LCM 4.9
LCM 4.9
Naprosyn 4.8
Rasagiline 4.8
Ferrous sulfate 4.7
Lepirudin 4.7
Campath 4.7
Campath 4.7
EML 4.6
Anagrelide 4.6
Arsenic trioxide 4.5
MRC 4.5
Micafungin 4.4
Etoposide 4.4
CPZ 4.3
Basiliximab 4.3
Basiliximab 4.3
CSF 4.3
Romidepsin 4.2
Ara-A 4.2
Red ginseng 4.2
Vorinostat 4.2
more...
Enzyme
BMT 6.4
CD13 5.9
DNA methyltransferase 5.8
STK4 5.6
cholesterol 25-hydroxylase 5.6
farnesyltransferase 5.6
deoxyguanosine kinase 5.5
farnesyltransferase 5.0
topoisomerase 4.8
topoisomerase 4.8
cancer procoagulant 4.5
isovaleryl-CoA dehydrogenase 4.5
PI-PLC 4.5
cytidine deaminase 4.4
PFI 4.4
phosphoglycerate kinase 4.4
ferrochelatase 4.2
TdT 4.2
CTP synthase 4.1
CYP7B1 4.1
riboflavin kinase 4.0
tryptase 4.0
MTD 3.8
oxoglutarate dehydrogenase 3.7
focal adhesion kinase 3.7
separase 3.7
ALA synthase 3.6
TGT 3.6
dCMP deaminase 3.6
deoxycytidine kinase 3.6
STR 3.6
cystathionine gamma-synthase 3.6
histone demethylase 3.5
CDH 3.5
isocitrate dehydrogenase 3.4
isocitrate dehydrogenase 3.3
neutrophil elastase 3.2
iduronate-2-sulfatase 3.2
thyroid peroxidase 3.2
pantothenate kinase 3.1
granzyme B 3.1
ribonucleotide reductase 3.0
CD10 3.0
ribonucleotide reductase 3.0
dihydropyrimidinase 2.9
ERK 2.8
MDR 2.8
factor C 2.8
Omi/HtrA2 2.6
FPS 2.6
trypanothione reductase 2.6
matriptase 2.5
polo-like kinase 1 2.5
mevalonate kinase 2.5
MCS 2.5
legumain 2.5
histone acetyltransferase 2.5
NOS 2.4
dUTPase 2.4
HCS 2.4
NQO1 2.4
PST 2.4
hypoxanthine-guanine phosphoribosyltransferase 2.3
carnitine acetyltransferase 2.3
cyclohydrolase 2.3
beta-amylase 2.3
P-glycoprotein 2.3
asparaginase 2.2
peroxidase 2.2
methionine synthase 2.2
demethylase 2.2
STK11 2.2
DMT 2.1
DAT 2.1
O-GlcNAc transferase 2.1
matriptase 2.1
reverse transcriptase 2.0
p80 2.0
lysozyme 2.0
matrix metalloproteinase 9 2.0
more...
Compound
5-Azacytidine 9.5
6-chloronicotinamide 9.1
3-fluorobenzamide 9.1
6-chloronicotinamide 9.1
Pipobroman 9.1
5-Aza-2'-deoxycytidine 8.4
Casuarinin 7.7
Conessine 7.7
DAC 7.7
MDMS 7.6
Homoharringtonine 7.5
Ara-C 7.4
Ara-C 7.2
Amifostine 7.1
Erythrocin 7.1
4 PA 6.9
2,2,4-trimethyl-1,2-dihydroquinoline 6.9
2-hydroxybenzohydrazide 6.7
13-cis-Retinoic acid 6.6
PDQ 6.6
TEL 6.3
Busulfan 6.3
Reticulin 6.3
Topotecan 6.2
2-naphthalenesulfonic acid 6.2
Cefozopran 6.2
PELS 5.9
K 10 5.9
URP 5.9
Geranylgeraniol 5.9
FXM 5.8
HMBA 5.7
Methylxanthine 5.7
Topotecan 5.7
INT 5.6
Oxindole 5.5
PPBP 5.5
RUB 5.4
TBI 5.4
DHB 5.4
Tetrahydrouridine 5.4
X 18 5.3
Danazol 5.3
DFS 5.2
HMBA 5.2
Pelargonidin 5.2
Thiotepa 5.1
Bestatin 5.0
Neo 5.0
Daunorubicin 4.9
TET 4.9
TET 4.9
Fosinopril 4.8
DEK 4.8
hydroxyglutarate 4.7
Benzene 4.7
Hydroxyurea 4.7
Menadione 4.6
Punicalagin 4.6
KTS 4.6
TMM 4.6
THD 4.6
Fast Blue B 4.5
DFO 4.5
Emetine 4.5
Tyrosol 4.5
Chlorambucil 4.5
PTMA 4.5
Deoxyuridine 4.5
WR-1065 4.4
VP-16 4.4
BCR 4.4
Paricalcitol 4.3
Combretastatin 4.3
NIX 4.3
TNA 4.3
Phenylpropanolamine 4.3
ONT 4.2
OPE 4.2
MME 4.2
more...