Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Stathmin 1
is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of
Stathmin 1
expression have been reported in leukemia and solid tumors. However,
Stathmin 1
has not been studied in
myelodysplastic syndrome
cells. We, herein, report that significantly higher
Stathmin 1
levels were observed in proliferating hematopoietic cells, in high-risk
MDS
and acute leukemia cells. In addition,
Stathmin 1
silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that
Stathmin 1
expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of
Stathmin 1
in hematological malignancies.
...
PMID:Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells. 2435 24
