Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Contrast demonstration of the distal dural sac and its contents is essential for an understanding of the regional pathology in cases of occult or previously operated non-occult forms of lumbar myelodysplasia. Only in this way is it possible to demonstrate the position of the conus medullaris, the course of the nerve roots, thickening of the filum terminale or other soft tissue abnormalities. Of various methods, the most detailed information can be obtained by the use of water soluble contrast injected after careful, high lumbar puncture (L 2/3). This is illustrated in five cases in which Dimer X was used. In view of its proven low neurotoxicity, Amipaque, which is now available in Germany, will be used in future.
 ...
PMID:[Myelography with water soluble contrast for malformations of the conus medullaris and filum terminale (author's transl)]. 14 2

Recent successful introduction of selective rhizotomy in the management of lower extremity spasticity in patients with myelodysplasia has prompted us to use it as a means of managing high pressure neurogenic bladders occasionally encountered in myelodysplastic patients. During the last 1 1/2 years 8 children have undergone selective sacral rhizotomy in an attempt to avert urinary diversion or bladder augmentation. Patient age ranged from 6.5 to 18.5 years. The level of the respective lesions was evenly distributed throughout the spine. At spinal surgery each patient had an electrode placed in the detrusor of the bladder via a suprapubic approach, electromyography electrodes were placed in the perineum and slow fill water cystometry was performed throughout the procedure. Standard electrophysiological stimulation of the nerve roots was performed to identify the rootlets that would only affect the detrusor and spare the external sphincter. Postoperative followup has been obtained on all patients. Of the patients 4 have exhibited significant improvement and they have not required augmentation, 2 have not shown any further deterioration in bladder function, 1 has demonstrated deterioration and 1 still lacks urodynamic followup. Postoperative cystometric studies have revealed a bladder capacity increase of 69% for the group. Uninhibited bladder contractions were abated in all but 1 patient. No patient has been rendered incontinent of urine from the procedure and no patient has had a problem with stool continence as a result of the rhizotomy. It appears that selective rhizotomy of the sacral roots has been able to increase bladder capacity as well as compliance in patients who normally would have been relegated to either bladder augmentation or urinary diversion. While these are encouraging results, some further followup is required to ascertain if the early improvements will be long-lasting.
 ...
PMID:Selective sacral rhizotomy in children with high pressure neurogenic bladders: preliminary results. 164 May 38

In 12 of 264 children treated with enterocystoplasty 15 spontaneous perforations occurred. Of the 12 children 9 had myelodysplasia. All segments of the gastrointestinal tract were used for the augmentation and most were detubularized. Surgery to increase bladder outlet resistance was done in 8 cases. At the time of each perforation 9 children had sterile cultures, however, 3 died of overwhelming sepsis. Presenting signs included abdominal pain in 8 cases, septic shock in 4 cases and shoulder pain in 4 older myelodysplastic children with diaphragmatic irritation from escaping urine. Cystography demonstrated a leak in 10 of 11 cases. Urodynamic studies revealed good compliance with low maximum filling pressure in 8 of 10 children. Hyperreflexia was noted in only 5 cases and outlet resistance greater than 85 cm. water was demonstrated in 5. Histological analysis showed changes in the bowel wall consistent with ischemia but suture granulomas were present in areas adjacent to the perforation site or thinned areas in biopsy or autopsy specimens. In addition to the theory that overdistention may cause enterocystoplasty perforation, current detubularization techniques may produce areas of relative ischemia, which become accentuated when the augmented bladder is distended beyond a reasonable volume.
 ...
PMID:Perforation of the augmented bladder. 164 May 50

A total of 38 infants and children with myelodysplasia was selected for statistical comparison of the effects of medium-fill and slow-fill saline cystometry on detrusor pressure. Medium-fill cystometry was performed at 20% of estimated bladder capacity per minute (up to 25 cc per minute) and slow-fill cystometry at 2% (up to 2.5 cc per minute). In 26 cases the filling rate did not determine the change in detrusor filling pressure while in 12 the change in detrusor filling pressure was greater than 15 cm. water during medium-fill but not slow-fill cystometry (p = 0.001). In 24 cases the filling rate did not determine the occurrence of maximal detrusor pressure greater than 40 cm. water but in 14 such pressure was noted during medium-fill but not slow-fill cystometry (p = 0.0005). Excluding 10 children with coexisting vesicoureteral reflux, differences in the change of detrusor filling pressure greater than 15 cm. water and maximal detrusor pressure greater than 40 cm. water remained statistically significant (p = 0.01 and p = 0.005, respectively). It is concluded that detrusor pressure can be manipulated by varying bladder filling with saline solution.
 ...
PMID:The effect of medium-fill and slow-fill saline cystometry on detrusor pressure in infants and children with myelodysplasia. 173 14

A method was developed for concentrating infectious pancreatic necrosis virus from hatchery water using positively charged 1-MDS filters. The method consists of passing large volumes (Ca. 1001) of hatchery water through 1-MDS microporous filter followed by the elution of the adsorbed virus using a high pH buffer. The virus adsorbed efficiently to 1-MDS filters when the pH of the water was 5.5 and was eluted optimally with 3% beef extract solution (pH 10). This procedure permitted the processing of 100 1 of hatchery water which resulted in a 300-fold reduction in the volume of water and greater than 90% recovery of the seeded virus.
 ...
PMID:Method for the concentration of infectious pancreatic necrosis virus from hatchery water. 186 6

We measured body composition, resting metabolic rate (RMR), and total energy expenditure (TEE) in a group of adolescents with cerebral palsy (CP) and myelodysplasia (M) aged 13- to 20-y-old using indirect calorimetry and the doubly labeled water method. Fat-free mass (FFM), RMR, and TEE were significantly lower in both the CP and M groups than comparable measurements in a control group of normal adolescent males and females. The ratio of TEE to RMR did not differ between controls and ambulatory M and CP subjects. However, TEE/RMR was significantly lower in the nonambulatory M and CP subjects than in controls (p less than 0.01). Our data indicate that energy requirements are reduced in both populations because both FFM and activity are decreased. Although energy requirements were decreased in both groups, the relationships between FFM and body weight differed. FFM and body weight were significantly correlated with RMR only in the M group. These data suggest that the type of paralysis in a handicapped population may affect resting energy expenditure.
 ...
PMID:Body composition and energy expenditure in adolescents with cerebral palsy or myelodysplasia. 200 Feb 62

A 29 year-old-man who had been diagnosed as having myelodysplastic syndrome (MDS) in August 1985 was re-admitted to our hospital because of fever and palpitation. His peripheral blood showed severe pancytopenia and bone marrow findings remained to be compatible with MDS (refractory anemia), but karyotype of bone marrow cells revealed 7 monosomy in 17 of 20 metaphases examined. Other laboratory findings revealed decreased serum haptoglobin, positive urine hemosiderin and the normal resistance of red cell membrane. In addition, both Ham test and sugar water test were negative. The titer of cold agglutinin was low, Donath-Landsteiner antibody was not detected. These findings suggested the association of autoimmune hemolytic anemia (AIHA), although both direct and indirect Coombs' test were negative. After administration of 50mg of prednisolone daily, the frequency of red cell transfusion was markedly decreased and transfused red cell life span was prolonged from 10.4 days to 27 days. Afterward, his hematological status rapidly transformed into that of acute nonlymphocytic leukemia about 13 months after admission and he died of gastrointestinal bleeding and cerebral bleeding. Cases of MDS with immunological disorder have been reported. This is, however, the first case of MDS associated with Coombs negative AIHA.
 ...
PMID:[Coombs negative autoimmune hemolytic anemia in a patient with myelodysplastic syndrome]. 202 40

Electronegative and electropositive filters were compared for the recovery of indigenous bacteriophages from water samples, using the VIRADEL technique. Fiber glass and diatomaceous earth filters displayed low adsorption and recovery, but an important increase of the adsorption percentage was observed when the filters were treated with cationic polymers (about 99% adsorption). A new methodology of virus elution was developed in this study, consisting of the slow passage of the eluent through the filter, thus increasing the contact time between eluent and virus adsorbed on the filters. The use of this technique allows a maximum recovery of 71.2% compared with 46.7% phage recovery obtained by the standard elution procedure. High percentages (over 83%) of phage adsorption were obtained with different filters from 1-liter aliquots of the samples, except for Virosorb 1-MDS filters (between 1.6 and 32% phage adsorption). Phage recovery by using the slow passing of the eluent depended on the filter type, with recovery ranging between 1.6% for Virosorb 1-MDS filters treated with polyethyleneimine and 103.2% for diatomaceous earth filters treated with 0.1% Nalco.
 ...
PMID:Development and application of new positively charged filters for recovery of bacteriophages from water. 205 44

A total of 61 patients with myelodysplasia underwent water cystometry and electromyography of the external sphincter. Of these patients 27 underwent video fluorourodynamics as a part of preoperative evaluation or instead of a voiding cystometrogram. Renal quantitative scintillation camera studies detected 7 patients with mild upper tract deterioration, even when other tests failed to do so. A total of 31 patients had upper tract deterioration as detected by excretory urography, ultrasound and/or renal scan studies, and were designated as group 1, while 30 had normal upper tracts and were designated as group 2. Bladder compliance in group 1 was significantly lower than that in group 2 (4.5 versus 11.3 ml./cm. water, p = 0.001). Leak pressure in group 1 was significantly higher than in group 2 (42.3 versus 26.1 cm. water, p = 0.019). In summary, patients with evidence of upper tract deterioration had lower bladder compliance and higher leak pressure than patients with normal kidneys.
 ...
PMID:The value of leak pressure and bladder compliance in the urodynamic evaluation of meningomyelocele patients. 223 38

Twelve aliphatic methacrylates with a carboxylic group [succinate (2 MES, 5 MPeS and 10 MDS), methylsuccinate (2 MEMS, 5 MPeMS and 10 MDMS), maleate (2 MEM, 5 MPeM and 10 MDM) and citraconate (2 MEC, 5 MPeC and 10 MDC)] were synthesized by the addition of four dicarboxylic acid anhydrides to each of three different alkylene chain length hydroxy methacrylates to investigate the relationship between the methacrylate structure and its bonding to tooth. The bond strength of methacrylates to polished tooth surface decreased with increasing alkylene chain lengths under dry conditions, but water immersion reduced this change. The bond strength of succinate and maleate to polished tooth surface was higher than that of methylsuccinate and citraconate under dry conditions. All methacrylates showed high bond strength to etched enamel, with maleate showing the highest bond strength. On the other hand, the bond strength of 2 MEM and 5 MPeM to etched dentin was markedly high, and about 5 microns thick resin reinforced dentin at the interface between etched dentin and resin (2 MEM or 5 MPeM) was observed by SEM and EPMA analysis.
 ...
PMID:[Adhesion of dental resin to tooth structure--syntheses and adhesion to tooth structure of various aliphatic methacrylates with a carboxylic group]. 270 Feb 51


1 2 3 4 5 6 7 Next >>