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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors consider the clinical and biological data of Acquired Idiopathic Sideroblastic Anemia (AISA). The physiopathology of the syndrome is discussed; the relationships between pathologic sideroblastosis, dyserythropoiesis and ferrokinetic modifications are pointed out. The associated abnormalities of granulocytic and megacaryocytic series linked AISA to other myelodysplasia.
Pathol Biol (Paris) 1979 Sep
PMID:[Acquired idiopathic sideroblastic anemia (author's transl)]. 38 22

A method for quantitative gas chromatographic determination of plasma lipids (free cholesterol, cholesteryl esters and triglycerides) in the low concentration range is described. This method permits a determination of not only the lipid classes mentioned above, but also their fractions according to molecular weight, down to 10 ng, without previous derivatization. Special attention was devoted to the preparation of columns with high efficiency and minimal losses of the test substances. The best results were obtained with a glass column 0.5 m x 2.0 mm I.D., packed with 1% OV-1 on Gas-Chrom Q (100--120 mesh). The processing of results is fully automated, using an MDS-2400 computer and includes the calculation of a non-linear calibration plot for each substance analyzed, accuracy control of the measured values, tabulation of the fwr values and the calculation for analyses of biological samples. For the calibration, the pure substances were used at 15 concentrations within a range of 10--1000 ng. The coefficient of variation calculated from 20 duplicate measurements of the calibration mixture did not exceed 5% for any component in the interval from 10 to 100 ng or 3% within range from 100 to 1000 ng.
J Chromatogr 1978 Sep 01
PMID:Automated quantitative gas--liquid chromatography of intact lipids. I. Preparation and calibration of the column. 70 23

A patient had a preleukemic syndrome in which the major manifestation was a chronic relapsing fever over an 18-month period. A review of the literature shows that fever may be present in a considerable number of patients with preleukemia.
JAMA 1976 Sep 13
PMID:Fever--a manifestation of preleukemia. 98 71

Cytogenetic abnormalities have been found in approximately 50% of all patients with acute leukemia. Although no chromosomal abnormalities have been found which are characteristic of a specific cell type, patients with AML and DiGuglielmo's syndrome more frequently have hypodiploid chromosome numbers, while patients with ALL seldom have hypodiploid numbers of chromosomes and may actually exhibit an extreme degree of hyperdiploidy in the leukemic cells. Chromosome analysis may be helpful in characterizing patients with preleukemia and DiGuglielmo's syndrome, and aneuploidy may correlate with shortened survival in these conditions. Although data so far available are conflicting concerning the relationship of aneuploidy to response to therapy in patients with acute leukemia, it is possible that as improved therapeutic regimens become available for the treatment of acute leukemia, more sophisticated cytogenetic analysis may be helpful in predicting survival and response to therapy.
Semin Oncol 1976 Sep
PMID:Cytogenetic heterogeneity of the acute leukemias. 106 28

According to the FAB classification, a patient (case 1) could not be diagnosed as MDS-RA, although she had clinical features of MDS, as compared with another patient (case 2) who was diagnosed as RAS and had abnormal karyotype (20q- and 5q-) of bone marrow (BM) cells. BM cells of the two patients were SCD (sister chromatid differentiation) negative. Rearrangement of c-erbB and c-erbA was found in the genome of the BM cells in both patients, when southern blot hybridization was performed with probe v-erbB+A. Therefore, case 1 could be diagnosed as preleukemia. During a period about 3 years of treatment with the drug stanozolol in case 1 there was good effect and successful reversion was obtained. She had then normal hematologic and cytogenetic patterns of BM and PB and the rearrangement of c-erbB of BM cells also disappeared. She has worked for two years since then. The mechanism of effective treatment and successful reversion was discussed briefly. Probe v-erbB was shown to be useful in investigation of gene diagnosis of preleukemia or MDS (shown elsewhere).
Zhonghua Nei Ke Za Zhi 1992 Sep
PMID:[Gene diagnosis and successful reversion in a patient with preleukemia]. 130 46

Erythropoiesis in response to erythropoietin (Epo) in myelodysplastic syndrome (MDS) in vitro and in vivo is severely impaired. We investigated the stimulative effect of c-kit ligand (KL) on the erythroid colony-forming abilities of bone marrow cells from 17 patients with MDS. The effects of normal donor-derived marrow were examined in comparison. Suppression of erythroid colony formation in MDS in response to Epo could not be restored by the addition of interleukin-3 (IL-3) to culture. In cultures dishes supplemented with KL, erythroid colony formation was dramatically enhanced, regarding both colony number and size. Colony-forming abilities by MDS progenitors were improved following costimulation with KL, particularly in refractory anemia (RA) and refractory anemia with ring sideroblasts (RARS); however, little enhancement was apparent following KL stimulation of marrow from patients with refractory anemia with excess of blasts (RAEB), refractory anemia with excess of blasts in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML). These results suggest that KL responsiveness of patients with low-risk MDS may still be intact, and that with progression to high-risk MDS, erythroid progenitors lose proliferative reactivity to both KL and Epo stimulation. KL may have a therapeutic role in restoring erythropoiesis in a subset of patients with MDS.
Blood 1992 Sep 01
PMID:Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome. 138 Dec 39

A case of myelodysplasia was found to have a complex bone marrow karyotype, involving an apparent whole-arm translocation between 17q and 18q. The application of a simplified fluorescence in situ hybridization technique, using directly fluorochrome-labeled centromere-specific alpha-satellite DNA probes, demonstrated the presence of sequences from both chromosomes 17 and 18 in the centromere of the derivative chromosome. This proves that a true whole-arm translocation had occurred. The case exemplifies how in situ hybridization analysis can be used to resolve interpretation problems in cancer cytogenetics.
Genes Chromosomes Cancer 1992 Sep
PMID:Identification of a whole-arm translocation by in situ hybridization with directly fluorochrome-labeled probes in a myelodysplastic syndrome. 138 48

The karyotypes of 98 patients between the ages of 8 and 81 years with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and chronic myeloid leukemia (CML) are presented. Although the well-described cytogenetic abnormalities associated with particular FAB subtypes in the West were observed, certain important local differences were noted. In ALL, hyperdiploidy was rarely observed, whereas the Philadelphia chromosome was observed in 50% of abnormal karyotypes. In AML, the t(8;21) was infrequently observed in M2 case, whereas trisomy 4 and 6, rarely reported elsewhere, formed 12% of the abnormal cases. In MDS, the incidence of -5/5q- and/or -7/7q- was 83% of cases with aberrant cytogenetic findings. Neither i(17q) nor an extra Ph was seen in 26 cases of CML including 9 cases of accelerated phase/blast crisis. In addition, previously unreported cytogenetic abnormalities occurring as single cases are presented. These findings are discussed in the context of geographical heterogeneity of chromosomal abnormalities in leukemia and emphasize the importance of continued epidemiologic studies of cytogenetics in hematologic malignancies.
Cancer Genet Cytogenet 1992 Sep
PMID:Cytogenetic analysis of hematologic malignancies in Hong Kong. A study of 98 cases. 139 2

A 15-year-old male with myelodysplastic syndrome (MDS) characterized by monosomy 7 was cytogenetically evaluated by metaphase karyotyping and fluorescence in situ hybridization (FISH) of interphase cells at six different points during the course of his disease. At diagnosis, there was complete agreement between metaphase and interphase findings. Interphase analysis alone provided important cytogenetic information on the first specimens received following intensive combination chemotherapy and bone marrow transplantation where metaphase analyses were uninformative. The detection of a minor post-treatment monosomy 7 population by interphase but not metaphase studies may have identified minimal residual disease prior to recurrence of MDS. From this longitudinal study, it is concluded that metaphase and interphase cytogenetic analyses form complementary approaches and that use of both provides greater analytical power when appropriate chromosome markers are available.
Cancer Genet Cytogenet 1992 Sep
PMID:Longitudinal cytogenetic study of metaphase and interphase cells in childhood monosomy 7 syndrome. 139 3

An unusual case of variant HCL with multiple ribosomal lamellar complexes and complex chromosomal changes is described. The karyotype of the main cell clone is characterized by involvement of chromosome 5 at q13.3 and interstitial deletion of 7q. However, there is no other evidence of myelodysplasia and the abnormal cells are of lymphoid origin with a B-cell immunophenotype. The clonal chromosomal evolution involves rearrangements at sites known to be specifically altered in lymphoid tumors.
Cancer Genet Cytogenet 1992 Sep
PMID:Complex chromosomal rearrangements in an unusual variant of hairy cell leukemia. 139 7


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