Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-one-year-old male patient with diagnosis of myelodysplastic syndrome and unstable angina was submitted to coronary angiography and implant of stent. His Blood cell count revealed 40,000 platelets/mm3. Coronary angiography with previous platelet transfusion showed obstruction of 80% of the right coronary artery (RCA). Following the administration of clopidogrel, the patient was submitted to another platelet transfusion and stent implantation in the RCA lesion. No bleeding was observed after the introducers removal. After 6 months, treadmill test was positive and new coronary aniography, in the same conditions, showed in-stent restenosis. This case report suggests that coronary stent implantation in patients with thrombocytopenia is a safe procedure, provided that prophylactic platelet transfusion is performed, although late restenosis may occur.
Arq Bras Cardiol 2006 Nov
PMID:In-hospital and late outcomes after coronary stenting in patient with unstable angina and myelodysplastic syndrome. 1739 86

The role of iron toxicity is well known in gastroenterology and hematology: hemochromatosis, thalassemia major and myelodysplastic syndromes represent iron toxicity models with evidence of serious damages to target organs such as the heart, the liver and endocrine tissues. Iron chelation therapy has dramatically changed the survival rate of thalassemia major since the introduction of desferoxamine with quantitative assessment of tissue iron overload by magnetic resonance imaging. Reperfusion hemorrhage is an independent predictor of left ventricular remodeling after acute myocardial infarction. Hemorrhage may be a source of iron toxicity and a mediator of inflammation, directly contributing to left ventricular remodeling. Iron chelation may potentially alleviate these cardiotoxic effects. Cardiac magnetic resonance imaging can provide insights into miocrovascular obstruction, hemorrhage and iron chelation.
G Ital Cardiol (Rome) 2013 Jun
PMID:[Iron overload and cardiotoxicity: from thalassemia to reperfusion damage]. 2374 40

Cardiac involvement in eosinophilia is potentially fatal and requires early diagnosis and prompt treatment. We report here the case of a 71-year-old female patient with eosinophilia>10,000/mm(3) for 2 months due to a myeloproliferative/myelodysplastic syndrome, with a rapidly progressive exertional dyspnea explained by an important circumferential eosinophilic pericarditis. Due to a rapid evolution to a tamponade, an emergent surgical drainage was performed. Subsequent medical treatment combined high-dose corticosteroids (1mg/kg/day) with hydroxyurea and imatinib. The outcome was favourable with regression of the effusion, of the volume overload symptoms and decrease in eosinophilia.
Ann Cardiol Angeiol (Paris) 2016 Feb
PMID:[A tamponade complicating an acute eosinophilic pericarditis due to a myeloproliferative/myelodysplastic syndrome]. 2570 28

Decitabine is a pyrimidine analogue of nucleoside cytidine, used for the treatment of myelodysplastic syndromes, chronic myelogenous leukemia, and acute myelogenous leukemia. We present a case of cardiomyopathy associated with decitabine used for secondary acute myelogenous leukemia. The patient presented with new heart failure symptoms and an ejection fraction decline.
Case Rep Cardiol 2018
PMID:Decitabine Induced Delayed Cardiomyopathy in Hematologic Malignancy. 3036 61