Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hemostatic disorders mainly due to thrombocytopenia represent an important clinical problem in patients with
myelodysplastic syndromes
(
MDS
). Much less is known about the possible coagulation abnormalities. Thirty patients with
MDS
were studied. Activity of
cancer procoagulant
(CP), concentrations of activation markers of coagulation and fibrinolysis such as thrombin-antithrombin complexes (TAT), prothrombin fragment 1+2 (F1+2) and D-dimers (DD) as well as standard coagulation tests were determined. Coagulation abnormalities concerned mainly patients with RAEB and RAEB-t. In this group the mean values of TATand F1+2 concentrations were significantly higher than in control indicating chronic coagulation activation similar to that observed in acute leukemias. CP activity in
MDS
patients did not differ from the control group.
...
PMID:Assessment of coagulation disorders and cancer procoagulant activity in patients with myelodysplastic syndromes. 1209
