Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recording of the intravesical pressure throughout the filling phase in children with low lumbar and high sacral levels of myelodysplasia showed detrusor hyperactivity which could be inhibited by anticholinergic medication in a dose-dependent manner under experimental conditions. Atropine as treatment for urinary incontinence during everyday activity was remarkably effective when given parenterally. Orally administered atropine was associated with 50-100% improvement of incontinence in six of 9 patients and 35-45% in the remaining three patients. Successful treatment with anticholinergic drugs requires careful selection of patients, including recording of the filling-phase intravesical pressure. Only in patients with detrusor hyperactivity is a good result of such treatment to be expected.
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PMID:Continence training of children with neurogenic bladder and detrusor hyperactivity: effect of atropine. 716 85

Bladder hyperactivity defined as unconscious, involuntary detrusor contractions giving rise to intravesical pressure increase of at least 15 cm H2O and of minimum 15 sec duration, has been examined in 9 children with myelodysplasia and incontinence. The effect of atropine and isoprenaline on the hyperactivity pattern was evaluated. Atropine had a dose-related inhibiting influence on both frequency and amplitude of detrusor contractions whereas isoprenaline was without these favourable effects.
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PMID:Influence of atropine and isoprenaline on detrusor hyperactivity in children with neurogenic bladder. 733 Jun 12