Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Iron overload is an undesired effect of frequent blood transfusions or genetic diseases.
Myelodysplastic syndrome
(
MDS
) patients become transfusion dependent, but due to the combination of ineffective haematopoiesis and repeated blood transfusions they are often subject to iron overload. In this study, we demonstrate that iron-overload mimicking condition alters bone marrow progenitor differentiation towards dendritic cells (DCs). Cells cultured in iron-enriched culture medium for seven days fail to differentiate into conventional CD11c
+
MHCII
hi
DCs and fail to efficiently respond to LPS (Lipopolysaccharides). Cells appear smaller than control DCs but vital and able to perform FITC-dextran (
Fluorescein
isothiocyanate-dextran) endocytosis. At molecular level, cells cultured in iron-enriched conditions show increased
ARG1
and
PU.1
, and decreased
IRF8
expression.
...
PMID:Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCII
low
CD11c
+
CD11b
+
F4/80
+
Cells. 3207 4
