Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Famciclovir
(
FCV
) is an antiviral drug that is often utilized after bone marrow transplantation to prevent viral infection. Yet, its role in hematopoiesis is poorly understood. Here, by utilizing a zebrafish model, we found that
FCV
exposure led to hematopoietic failure by impairing the proliferation of hematopoietic stem and progenitor cell (HSPC) and inducing HSPC apoptosis. On the other hand,
FCV
treatment could effectively relieve myeloid malignancies in the c-myb
hyper
MDS
-like fish model, and played a role not only in the embryonic stage but also in adult zebrafish. This study reveals that
FCV
functions as a double-edged sword, with hematotoxicity at a high level, but that appropriate
FCV
treatment may be beneficial for the treatment of
MDS
.
...
PMID:Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish. 3320 48
