Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred patients 10 years of age or older with myelodysplasia were evaluated to compare located versus dislocated hips with regard to neurologic level, ambulation, hip pain, skin condition, and spinal deformity. Operated and nonoperated individuals were compared. Analysis was carried out to determine what the overall long-time function was in located, dislocated, and "relocated" individuals. Of the 100 patients, 72 presented at follow up with bilateral located hips, 18 with unilateral hip dislocations, and 10 with bilateral dislocations. Twenty patients functioned at T12 levels or above, 30 patients had preservation of anterior thigh musculature, and 25 patients had posterior leg or hip abductor power. Thirteen patients (15 hips) were found to have some degree of pain, 1 patient with bilateral dislocation, 5 with unilateral dislocation, and 7 with bilaterally located hips. Ambulatory function was not affected in any neurologic group by location versus dislocation of the hips. Skin ulceration problems were not increased in patients with hip dislocation. Major spinal deformity in most groups correlated highly with neurologic levels, but not with location versus dislocation of the hips. In one group, an increase in lumbar lordosis was present in unilateral hip dislocations. This study suggests that adolescents and young adults with myelodysplasia have different functional levels related to the neurologic level which are not related to whether the hips are located or dislocated.
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PMID:The role of hip location and dislocation in the functional status of the myelodysplastic patient. A review of 100 patients. 265 80

The present study describes a case of leg lymphedema due to iliopectineal bursitis associated with rheumatoid arthritis (RA), which was satisfactorily controlled by surgery and combination therapy with methotrexate (MTX) and tacrolimus. A 68-year-old male, who had a six-year history of RA, developed an iliopectineal bursa associated with destruction of the hip joint. The mass gradually increased in size, and there was swelling in his right lower extremity. The patient was subsequently hospitalized with increasing right hip pain and leg edema. A colorless transparent lymph fluid leaked from his leg, and leg lymphedema was thus diagnosed. The patient also had a 20-year history of myelodysplastic syndrome. Therefore, the extensive or total resection of the bursa was considered to be too invasive, so a partial bursal excision was performed via an anterior approach. Following the partial bursal excision, total hip arthroplasty (THA) was performed using the Hardinge approach. The leg lymphedema disappeared following the surgery, and the iliopectineal bursa was no longer enlarged. MTX and tacrolimus were postoperatively administered to strictly control the RA. The RA was subsequently well controlled, without any increases in the levels of inflammatory markers, such as C-reactive protein and matrix metalloproteinase-3. This case demonstrated that iliopectineal bursitis was resolved following THA, without complete excision of the intrapelvic bursa, and that strict RA control led to a good clinical course without recurrent inflammation of the bursa. Similar procedures may be beneficial in other patients contraindicated for resection of the entire bursa.
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PMID:Leg lymphedema caused by iliopectineal bursitis associated with destruction of a rheumatoid hip joint: A case report. 2413 83