Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Urodynamic evaluation was performed in 46 children with myelodysplasia, spinal cord injury, enuresis, postoperative incontinece, sacral agenesis and recurrent urinary tract infection. The basic study consisted of voiding cystourethrography followed by the simultaneous recording of intra-abdominal and intravesical pressure with external urethral sphincter electromyography. Urethral pressure profile, urinary flow rate and anal sphincter electromyography were performed selectively. There was no correlation between the clinical neurological level and the cystometric pattern in patients with spinal cord lesions. Bladder-external sphincter dyssynergia was associated with a high post-void residual urine in children with hypertonic bladders, while in children with hypotonic bladders dyssynergia did not affect the post-void residual. Since, urinary symptoms bore little relationship to urodynamic findings in our study we recommend complete evaluation of children who have persistent disturbances of micturition.
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PMID:Changing concepts in the urodynamic evaluation of children. 87 55

The surgical management of sphincteric incompetence in patients with myelodysplasia is a formidable problem. In 10 female patients and 4 male patients with myelodysplasia a free graft of rectus fascia was used to suspend the urethra, termed the periurethral and puboprostatic sling procedures, respectively. All but 1 patient also underwent augmentation cystoplasty, usually with sigmoid colon. Patient age ranged from 7 to 25 years (mean 12.6 years) and followup ranged from 2 to 27 months (mean 12 months). Of the patients 12 are completely dry on clean intermittent catheterization, 1 has undergone 2 subsequent urethral suspension procedures but remains incontinent and 1 experiences nocturnal enuresis but is dry during the day. The periurethral sling appears to be as effective as the artificial urinary sphincter, the Young-Dees-Leadbetter bladder neck reconstruction and the Kropp procedure in the management of sphincteric incompetence in female patients. In male patients experience with the puboprostatic sling is limited but thus far it is encouraging.
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PMID:Periurethral and puboprostatic sling repair for incontinence in patients with myelodysplasia. 237 17

In a number of diseases in childhood (vesico-ureteral reflux, myelodysplasia, recurrent urinary tract infection, enuresis) it is important to evaluate the functional patterns of the micturition phase. The therapeutic regimen is influenced especially by changes of the urethral flow resistance. The value of urodynamic methods which are available for the characterization of the micturition phase is limited because of the small anatomic conditions in childhood. The presented method of measurement of the intraurethral urinary flow using an ultrasound doppler technique is recommended as an alternative technique because of its superior diagnostic safety and unrestricted application in childhood.
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PMID:[Characterization of intraurethral relations of urine flow in childhood using the Doppler ultrasound technic]. 307 Oct 36

A total of 14 women and 6 men 19 to 39 years old (mean age 27 years) with myelodysplasia underwent undiversion 8 to 29 years (mean 16) after ileal conduit diversion. The main reasons for diversion were incontinence in 17 patients and failed ureteral reimplants in 3, and those for undiversion were a desire for an improved quality of life in 16, increasing hydronephrosis in 4 and stomal problems in 3. Preoperative assessment included upper and lower tract imaging, and video urodynamics. Operations on the ureters included reimplantation into an intussuscepted nipple valve in 8 patients, tunneled reimplants into a sigmoid augmentation in 3 and the ureters joined to either the bladder or lower ureter without interposing bowel in 9. All reimplantations were done with nonrefluxing techniques. A total of 18 patients underwent bladder augmentation and 2 women in whom cystectomy was performed for pyocystis underwent substitutions. Simultaneous continence procedures in 18 patients included trigonal tubularization in 2, artificial sphincter implantation in 2, a bladder neck sling in 5 or bladder neck tapering and a sling in 9. The patients were followed for a mean of 69 months (range 21 to 133). Eight patients required reintervention within 1 year for problems, such as anastomotic leak in 1, bladder neck obstruction in 1, incontinence in 1, artificial urinary sphincter revisions in 1 and bladder stones in 1. One patient had a recurrent renal calculus 10 years after undiversion. All patients experienced either persistence of normal upper tract appearance or improvement and/or stabilization of hydronephrosis. Mean bladder capacity was 77 cc preoperatively and 480 cc postoperatively, while mean pressure at capacity decreased from 50 to 14 cm. water with detubularized augmentation. Of the patients 17 are completely dry, 2 wear 1 pad per day and 1 has enuresis. All but 1 patient who voids with straining are on intermittent self-catheterization. All patients, on followup interviews, reported an improved quality of life without a stoma. We conclude that undiversion provides an improved quality of life and an acceptable morbidity rate. The choice of operation depends on the anatomy of the patient. We prefer a nonprosthetic type of incontinence procedure when intermittent self-catheterization is to be done. No long-term morbidity has yet been noted.
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PMID:Urinary undiversion in adults with myelodysplasia: long-term followup. 801 64

A great deal of methods were used to evaluate the urinary tract in patients with myelodysplasia; however, the authors failed to find an informative and easy-to-use diagnostic approach. In the authors' opinion, a simple, available, non-invasive, and safe screening that includes ultrasonography of the bladder and kidneys before and after attempted urination, visualization of urination, squeezing-out test, and general urinalysis should form a basis for diagnosis. The pattern of urination, enuresis, urinary tract infection, obstructive uropathies, the volume of residual urine, the thickness of the detrusor urinae are the basic parameters identified at primary diagnosis. The presence of residual urine serves as a basis for further examination, involving cystography and urodynamic study occasionally supplemented by excretory urography and other techniques.
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PMID:[Urological complications in children with myelodysplasia]. 1118 29