Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Changes in bone marrow niches can lead to the occurrence of
myelodysplastic syndrome
(
MDS
). As an important part of the bone marrow niche, osteoblasts serve a key role in the progression of
MDS
. The present study investigated the quantity and function of osteoblasts and, through
in vitro
assays, detected changes in signaling pathways and the association with progression in
MDS
patients. The ratios of osteoprogenitors (CD34
+
OCN
+
) and OCN
+
CD34
-
Lin
-
osteoblasts in
MDS
patients were significantly less than those of normal controls. The results of this study demonstrated that the quantity and activity of osteoblasts in
MDS
patients were lower than those in normal controls. Furthermore the activity of osteoblasts in patients correlated with the severity of
MDS
. The quantity of osteoblasts cultured
in vitro
from high-risk and very high-risk
MDS
patients (WHO Classification-Based Prognostic Scoring System score 3-6) was decreased. The levels of T-cell immunoglobulin and mucin domain-containing 3 (TIM3) and
Jagged 1
were also increased in the osteoblasts
in vitro
. These results indicated that osteoblasts are abnormally altered in
MDS
patients, and that there are associations between abnormal changes of osteoblasts and the severity of
MDS
.
...
PMID:Abnormal changes in the quantity and function of osteoblasts cultured
in vitro
in patients with myelodysplastic syndrome. 3021 73
