Gene/Protein
Disease
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Drug
Enzyme
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Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
miR-378 has been proven to inhibit cell growth, migration and invasion in different types of cancers. In this study, we found that miR-378 was commonly downregulated in the bone marrow cells obtained from
myelodysplastic syndrome
(
MDS
) patients. We further investigated the role of miR-378 in the proliferation and apoptosis of SKM-1 cells, an acute myeloid leukemia cell line established in the leukemic phase during the progression of
MDS
to AML (
MDS
/AML). Results indicated that overexpression of miR-378 in SKM-1 cells interfered with proliferation via inducing apoptosis and G0/G1-phase cell cycle arrest, and suppressive effect of miR-378 on
MDS
/AML cells may be mediated partly through Bcl-w and
CDC40
. Moreover, apoptosis induced by miR-378 correlated with increased expression of Bax and activation of caspase-3, -8 and -9. Taken together, our data support a critical role for miR-378 in the pathogenesis of
MDS
and provide a novel therapeutic target in this complex disease.
...
PMID:miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. 2763 96
