Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026986 (
myelodysplastic syndrome
)
14,926
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Death-associated protein kinase 1
(
DAPK1
), a proapoptotic serine/threonine kinase, is a candidate tumor suppressor gene. We studied the methylation status of the promoter region of the
DAPK1
gene and the expression of the DAPK1 protein in 78 bone marrow samples from untreated patients with
myelodysplastic syndrome
(
MDS
) by PCR and Western blot analysis. Hypermethylation of
DAPK1
was present in 42.3% (33 of 78) of
MDS
specimens and was significantly correlated with the loss of
DAPK1
mRNA and protein expression (p < 0.01). There were no significant differences in methylation frequency among subgroup of
MDS
.
DAPK1
hypermethylation in
MDS
was associated with the presence of cytogenetic abnormalities in the bone marrow at the time of the initial diagnosis. A higher frequency of
DAPK1
hypermethylation was found in the unfavorable cytogenetic risk group (12 of 21 cases; 57.1%) compared to the favorable cytogenetic risk group (5 of 20 cases; 25.0%, p = 0.0368). These findings suggest that suppression of
DAPK1
expression by DNA methylation may play a substantial role in the development of
MDS
.
...
PMID:Aberrant methylation of death-associated protein kinase 1 CpG islands in myelodysplastic syndromes. 2121 58
