Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

PURPOSE. To report an elderly patient with a primary myelodysplastic syndrome (MDS) type refractory anemia with excess of blasts (RAEB) who developed an orbital granulocytic sarcoma (GS) as a harbinger of an acute myelogenous leukemia (AML). METHODS. A 77-year-old man was diagnosed as having a MDS type RAEB. Eight months later he developed a progressive painless proptosis in his left orbit. A computed tomography (CT) scan revealed a large irregular mass involving the orbit. It showed heterogeneous soft tissue density and no osseous cortical destruction was observed. A diagnostic lateral orbitotomy with an excisional biopsy were performed. RESULTS. Histopathology showed sheets of immature granulocytic cells. Immunohistochemical staining was positive for markers for myeloperoxidase, which supported the diagnosis of GS. CONCLUSIONS. Reports of a GS complicating the course of a MDS are few. Sites of detection of the extramedullary tumors (EMT) in MDS vary, although cutaneous sites predominate. An orbital site is a very rare localization of this tumor in adults. The case we report is the first one with an orbital granulocytic sarcoma in an MDS-type RAEB in an elderly patient.
Orbit 1999 Dec
PMID:Orbital granulocytic sarcoma in a myelodysplastic syndrome. 1204 74

Myeloid sarcoma (MS), also known as granulocytic sarcoma (GS) or chloroma (named for the greenish hue attributed to the pigment of myeloperoxidase [MPO]), is a rare solid tumor with a predilection for the orbit. MS usually occurs in conjunction with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative disorder (MPS) and may be the harbinger of disease. Therefore, prompt diagnosis is essential for patient survival. We present a rare case of a 61 year old with an isolated orbital MS without active leukemia.
Orbit 2016
PMID:Myeloid sarcoma of the orbit without systemic recurrence of disease in an adult: A clinicopathological case report. 2690 83