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Query: UMLS:C0026986 (myelodysplastic syndrome)
 14,926 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors consider the clinical and biological data of Acquired Idiopathic Sideroblastic Anemia (AISA). The physiopathology of the syndrome is discussed; the relationships between pathologic sideroblastosis, dyserythropoiesis and ferrokinetic modifications are pointed out. The associated abnormalities of granulocytic and megacaryocytic series linked AISA to other myelodysplasia.
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PMID:[Acquired idiopathic sideroblastic anemia (author's transl)]. 38 22

The present investigations confirm and extend previous reports on the occurrence of cytochemical anomalies among the hemopoietic cells in preleukemia. The cytochemical patterns of the hemopietic cells obtained from 19 patients suffering from a preleukemic disorder have been studied. The diagnostic value of the cytochemical examination using a panel of 10 different tests is emphasized. In a prospective study in 17 out of 25 patients, preleukemia had been correctly diagnosed. In 4 patients leukemia developed within 2-4 months from the diagnosis ('imminent leukemia'), in 13 patients leukemia or smouldering leukemia developed between 4 and 25 months after the diagnosis ('true preleukemia'). The cytochemical profiles of the hemopoietic cells of the latter have been compared with those of 14 patients suffering from aplastic anemia. In preleukemia the blasts did not exceed 3% of the nucleated bone marrow cells. The clinical value of the diagnosis 'preleukemia' is discussed as well as the prognosis and the possible therapeutic approaches.
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PMID:Detection of cytochemical and morphological anomalies in 'preleukemia'. 41 1

Two patients with presumably benzene-induced malignant blood disorders with preleukemic phases were cytogenetically monitored through the courses of their diseases. Patient 1, in addition to a familial chromosome translocation [t(3;16)], developed karyotypic abnormalities in 100% of the marrow cells, including two translocation: t(9;16)] and t(4;15). Monosomy of chromosome 7 characterized the cells of patient 2. Cytogenetic monitoring of the patients at various phases of their diseases served as an important indicator of the transformation or progression of the preleukemia into frank leukemia and of the unusual behavior of such leukemic cells.
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PMID:Chromosome analysis in two unusual malignant blood disorders presumably induced by benzene. 42 7

Children with myelodysplasia are best managed in medical centers by a team consisting of a urologist, an orthopedist, a neurosurgeon, a pediatrician, a social worker, an orthotic technician and physical therapists. A co-operative approach aids in the selection of a urinary diversion stoma site which will not interfere with the multiple orthopedic procedures these children must undergo. The urologic and orthopedic complications and benefits of 24 patients with umbilical stoma are compared with 24 patients with matched right lower quadrant stoma. The incidence of urologic complications is equal, while the orthopedic advantages manifest by the first group vastly outweigh the problems encountered in the second group. We advocate the use of a midline stoma site for urinary diversion in children with myelodysplasia.
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PMID:Use of the umbilical area for placement of a urinary stoma. 43 67

The clinical, hematologic and histologic characteristics of six patients with refractory anemia with deletion of the long arm of chromosome No. 5 are described. These patients had a distinct hematologic picture with macrocytic anemia of mild to moderate severity, normal to low leukocyte count and increased platelet count. The long arm of chromosome No. 5 was deleted in the majority of bone marrow metaphases. The main cause of anemia was underproduction with decreased erythroid precursors in the bone marrow and no increase in peripheral blood reticulocytes. Two of five patients responded transiently to the administration of androgens. In vitro evaluation of the bone marrow growth pattern in semisolid agar culture system was performed in three patients and was found to be normal and distinct from that in patients with preleukemia. In a follow up of up to five years, no patient had changed hematologically and in none had leukemia developed. The 5q-syndrome is a distinct hematologic entity and probably more common than hitherto realized. This diagnosis may have therapeutic and prognostic implications.
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PMID:Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. 45 27

The diagnostic demands of the neurogenic disturbances of the voiding of the bladder in patients with myelodysplasia are summarized in tabulated form. It is reported in detail on own experiences of the authors with urodynamic measuring methods and with the electromyography of the striated musculature of the floor of the pelvis. At present the two methods are not yet used everywhere and they are a considerable enrichment of the diagnostics.
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PMID:[Neurogenic bladder dysfunction in childhood. I. Diagnosis]. 46 70

A new technique is described which enables children with neurogenic bladder secondary to myelodysplasia to learn self-catheterization prior to their school years. Inexpensive dolls, complete with male or female genitalia, and a specially designed mirror to magnify the female children's genitalia, were used with four children (three girls, one boy) with mental ages of five years. Each child successfully demonstrated self-catheterization within two days, and gradual progress toward complete independence has been promoted.
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PMID:Teaching intermittent self-catheterization to young children with myelodysplasia. 46 19

The chick embryo is a useful experimental model for investigating neural dysraphism. Windowing at 26 h incubation is by itself teratogenic, resulting in predominantly neural tube defects. A histological study of a regular series of specimens between pre-neurulation and later stages was undertaken. Open brain defects occurred at every stage after the expected closure of the anterior neuropore, suggesting that they arose by non-closure, myeloschisis was preceded by a characteristic triangular shape of the rhomboid sinus. Serial sections revealed regular open defects, with separation between the neural plate and tail-bud sources of neural tissue, but continuity of the neural plate into the caudal region. These findings suggest that myeloschisis arises by nonclosure of the neural folds. The establishment of myeloschisis was followed by local separation of the notochord from an open area of neural tube, but not by overgrowth of neural tissue. Myelodysplasia appeared at about the time of expected closure of the rhomboid sinus. Serial sections revealed irregular open defects, with complete absence of neural plate material and formation of the cord tissue from tailbud material alone. The lesions were accompanied by extensive cystic and hemorrhagic changes in local mesoderm, with reduction in somite volume. There was no associated notochordal separation.
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PMID:Histogenesis of experimental open neural defects in the early chick embryo. 50 87

A method is discussed and illustrated which yields a geometric representation of asymmetric proximity matrices. Assuming the observations are metric the data matrix is uniquely decomposed into a symmetric and a skew-symmetric matrix-valued component. The former entails a spatial configuration vis some MDS technique; the formation contained in the latter can then be integrated into this space in various ways.
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PMID:[A procedure for analyzing metric asymmetric proximity matrices (author's transl)]. 54 96

In the past 2 years, no supravesical urinary diversions have been done for myelodysplasia at St. Louis University Medical Center. Twenty-six patients with neuropathic bladders have been managed by intermittent catheterization and mechanical devices. The addition of anticholinergic and alpha-adrenergic agents to the therapeutic regimen has markedly increased the numbers of satisfactory results. Based on this group of patients, we are encouraged to believe that supravesical urinary diversion is rarely necessary for the management of both the medical and social problems of the urinary tract associated with myelodysplasia.
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PMID:Pharmacologic modification of therapeutic measures used in managing the neurogenic bladder. 58 76


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