Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026936 (Mycoplasma)
 14,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the last years, diagnosis and therapy of prostatitis have advanced rapidly. A detailed standardized diagnostic procedure is mandatory to delimit inflammatory from noninflammatory variations of the prostatitis syndrome. Whereas Gram-negative pathogens are agreed to be etiologically responsible, the relevance of chlamydia and mycoplasma is still under debate. Further diagnostic work-up should comprise ejaculate analysis, screening of the bladder voiding and transrectal prostatic sonography. The therapy of the inflammatory prostatitis is aimed to the demonstration of relevant pathogens, antibiotic treatment must be suited to expected sensitivity of the pathogen. Surgical procedures may be discussed when antibiotic treatment has failed. If it is not possible to identify relevant pathogens, the therapy remains of experimental character. Prostatodynia as noninflammatory disease often requires psychodynamic exploration.
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PMID:[Prostatitis]. 760 92

Seventy-eight men with symptoms of chronic or subacute prostatitis were enrolled. Investigations for the presence of Chlamydia trachomatis in urethral swabs were carried out. The expressed prostatic secretions were additionally examined for Mycoplasma hominis, Ureaplasma urealyticum, Gardnerella vaginalis, other gram-negative and gram-positive bacteria, Trichomonas vaginalis, yeast-like fungi and leucocyte count. Furthermore, all patients were evaluated for the presence of serum anti-chlamydial IgG antibodies. Signs of inflammation on the basis of the count of leucocytes per hpf in the prostatic secretions were detected in 42 patients (group I). Prostatodynia was found in the remaining 36 men (group II). In group I, chlamydial antigen was detected in the urethra and expressed prostatic secretions (EPS) in 6 (14.3%) and 9 (21.4%) patients, respectively. No evidence of current chlamydial infection was found in group II. The presence of serum anti-chlamydial IgG antibodies was demonstrated in 13/42 (30.9%) patients with prostatitis and in 3/36 (8.3%) patients with prostatodynia (P < 0.01). The results suggest that chlamydia may be one of the causative agents of chronic prostatitis.
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PMID:Chlamydia trachomatis: probable cause of prostatitis. 987 30