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Query: UMLS:C0026936 (Mycoplasma)
 14,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred consecutive infertility patients and sixty-seven controls subjects were studied for the incidence of infection with Ureaplasma urealyticum (T-mycoplasma). On the basis of a complete infertility investigation, the infertility patients were subdivided into those with explained infertility and those with unexplained infertility. Of the patients with unexplained infertility, 55% had a positive culture for T-mycoplasma as compared with a 32% incidence of positive cultures in the control population. The differences were statistically significant. The 6-month pregnancy rate following successful antibiotic treatment in patients with unexplained infertility was 42%. The 6-month pregnancy rate in a comparable group of patients with unexplained infertility, seen during a 3-year period prior to mycoplasma culture and treatment, was 32%. The difference in pregnancy rates between the two groups was not statistically significant. No correlation was found between a poor postcoital test and the presence of T-mycoplasma infection nor between T-mycoplasma infection and poor cervical mucus. The role of T-mycoplasma infection in infertility was neither proven nor disproven by this study.
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PMID:On the etiologic role of ureaplasma urealyticum (T-mycoplasma) infection in infertility. 56 66

In 46 patients with a history of habitual abortion and in 18 women with primary unexplained infertility, cervical mucus and endometrial tissue samples were examined for presence of T-mycoplasma, and the results were compared to those obtained amoung 45 control subjects. Colonization of T-mycoplasma in the cervix was found to be common in all patient groups (49-83%), whereas colonization in the endometrium was found to be significantly more frequent among habitual abortion patients (28%) and the infertility patients (50%) than amoung control subjects (7%). In all patients having T-mycoplasma-positive endometria, the organism was also isolated from the cervix, thus indicating an ascending route for the colonization of the uterine cavity. Bacteria belonging to the normal vaginal flora were frequently co-isolated from the endometrial samples along with T-mycoplasma. The women with T-mycoplasma-positive endometria showed a high incidence of postabortion fever. Treatment with doxycycline eradicated T-mycoplasma from the cervix and endometrium and apparently led to an improvement with respect to the outcome of posttreatment pregnancies.
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PMID:Uterine T-mycoplasma colonization in reproductive failure. 62 70

To improve the method for identification of Mycoplasma as a cause of unexplained infertility and to test whether mycoplasmal endometritis could be responsible for reproductive failure, successful endometrial jet washing technique was performed on 59 infertile patients. Sixteen patients (27%) showed positive Mycoplasma growth. Five patients (31%) from this group became pregnant within a few months following an antibiotic treatment. These results were compared with 50 control patients and only 3 (6%) showed positive Mycoplasma growth from endometrial washings. The data reported in this paper support the concept that endometritis due to Mycoplasma of T-strain or hominis can be a cause of infertility.
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PMID:Irrigation technique for detection of Mycoplasma intrauterine infection in infertile patients. 72 77

The presence of Mycoplasma hominis was investigated in 100 patients with gynecologic diseases, 20 infertility cases and 50 cases of abortion in the 2nd--3rd month of pregnancy. M. hominis could be isolated from the vaginal secretions of 20 patients with gynecologic diseases and of 3 infertility cases. Eighteen M. hominis isolates were recovered from 13 patients with abortion (8 strains from the placenta and 10 from vaginal secretions). High titers (1/64--1/512) of complement fixing antibodies to M. hominis were found in 16 patients with gynecologic diseases, 12 infertility and 17 abortion cases.
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PMID:Prevalence of Mycoplasma hominis in patients with gynecologic diseases and abortion in the 2nd--3rd month of pregnancy. 74 35

The presence of T-mycoplasmas in semen specimens from 625 men with infertility of unknown etiology was correlated with seminal cytologic findings. A change in the distribution toward higher ejaculate volumes and lower counts was demonstrated in the 246 patients with positive T-mycoplasma cultures, compared with the 379 patients with negative cultures. There was a significant increase in the number of tapering forms and spermatids in the T-mycoplasma-positive group. The increases in aberrant forms occurred at the expense of the oval and microcephalic forms. This change in the cytologic picture is consistent with the "stress" pattern seen in viral infections and allergic reactions, with the exception of the specific decrease in microcephalic forms. Relatively fewer patients with T-mycoplasmas in their semen had a high-level spermatozoal motility, compared with those lacking T-mycoplasmas. More than half again as many patients with T-mycoplasma infections had the poorest levels of spermatozoal motility. Infertile patients with T-mycoplasma infections had an over-all decrease in semen quality compared with those lacking demonstrable T-mycoplasmas.
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PMID:T-mycoplasmas and human infertility: correlation of infection with alterations in seminal parameters. 80 36

T-strain mycoplasmas have been incriminated in nongonococcal urethritis in human males and human reproductive failure in females. In this study, T-strain mycoplasmas were isolated from the genital tracts of 3 genera of female monkeys: talapoins (Miopithecas talapoin), patas (Erythrocebus patas), and macaques (Macaca fascicularis). The talapoin monkeys had a record of a high rate of reproductive failure due to infertility, spontaneous abortions, and stillbirths. The patas monkeys also had reduced fertility. The 3 genera had no contact with each other. Details of cultural methods for detecting mycoplasmas are given. T-strains isolated from the vaginas of the monkeys were similar in cultures to those isolated from humans but not closely related to human T-mycoplasma serotypes. These findings broaden the number of species which harbor T-mycoplasma and provide an animal model for experimental studies.
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PMID:T-strain mucoplasmas and reproductive failure in monkeys. 80 83

The genital mycoplasmas, Mycoplasma hominis and Ureaplasma urealyticum eT-mycoplasmas) are common vaginal organisms. They are acquired primarily through sexual contact. There is evidence, some of it highly suggestive, linking the genital mycoplasmas to involuntary infertility, spontaneous abortion and low birth weight. Additional controlled treatment studies are needed in each of these areas to assess fully the role of the genital mycoplasmas. M. hominis has the potential to invade the blood stream and is responsible for some instances of fever following abortion and of postpartum fever.
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PMID:Genital mycoplasmal infections: their relation to prematurity and other abnormalities of reproduction. 106 74

Seminal fluid from males complaining of infertility was examined for the presence of T-mycoplasmas and Mycoplasma hominis. No significant difference, with regard to the presence of mycoplasmas, was found between the seminal fluid which had normal cytology and seminal fluid of which the cytology was deemed pathological. Colonisation was shown to be an evanescent phenomenon, and female consorts often had different mycoplasma flora to the males. No positive role of mycoplasmas in the pathogenesis of infertility could be shown.
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PMID:The role of Mycoplasma in human infertility. 126 43

Mycoplasmas have been well established as pathogens of the bovine urogenital tract, and produce pathologic lesions resulting in infertility. Serologic examination of cattle with infertility problems with Mycoplasma bovigenitalium and Mycoplasma agalactiae subsp. bovis show a high incidence of positive reactors suggesting that mycoplasmas play an important role in bovine infertility. The similarities of pathologic lesions in the urogenital tract of cattle and women with infertility problems and the frequency of isolation of mycoplasmas from human females suggest closer examination for mycoplasmas in human infertility. Studies with bulls suggest that mycoplasmas as a cause of human male infertility should not be ignored.
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PMID:Infertility of cattle caused by mycoplasmas. 127 Feb 64

Seventy two infertile men were studied. History of small pox and mumps infection was noted in 4 and 3 patients respectively. Seven patients had varicocele (9.2%), and small atrophic testes were found in 9 (12.5%). Azoospermia was reported in 41 (58.3%) and oligospermia in 17 (23.6%), and 14 patients (19.4%) had normal sperm counts. Mycoplasma were grown from urethral swabs in 25 (35%) patients. Mean LH and FSH were elevated in azoospermics (p less than 0.001), E2-17B in oligospermics (p less than 0.001) and FSH in normospermic (p less than 0.01) patients. Hypergonadotropism suggestive of primary testicular failure was recorded in 43 (59.7%) patients. Hypogonadotropism was noted in 3 (4%) and hyperprolactinemia due to pituitary microadenoma induced infertility in only one patient. No aetiology could be determined in 11 (16%) patients.
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PMID:Aetiologic factors in male infertility: clinical, microbiological and hormonal evaluation. 163 74


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