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Query: UMLS:C0026936 (Mycoplasma)
 14,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Armstrong, D. (The Children's Hospital of Philadelphia, Philadelphia, Pa.), and K. Paucker. Effect of mycoplasma on interferon production and interferon assay in cell cultures. J. Bacteriol. 92:97-101. 1966.-The influence of mycoplasma on the production and action of interferon was studied in cultures of both L and human embryonic kidney (HEK) cells. Mycoplasma hominis 1, the Negroni agent, and the F12 mycoplasma were used for infection of L cells, and M. hominis 1 and M. pneumoniae for inoculation of HEK cells. All strains were capable of multiplication in the culture systems employed. None produced detectable levels of interferon, and responsiveness of the cells to induction of interferon by virus remained unaltered. Infection with mycoplasma did not impair the sensitivity of the cells to the action of interferon, nor was the replication of vesicular stomatitis virus noticeably diminished.
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PMID:Effect of mycoplasma on interferon production and interferon assay in cell cultures. 428 5

The effects of an arginine-utilizing mycoplasma, Mycoplasma arginini, and of varying levels of arginine in the growth media of the Epstein-Barr virus (EBV)-containing EB1 and EB3 cell lines, and the EBV-free RPMI 1788 cell line, were studied. l-Arginine, at a concentration of 0.1 mM in the growth medium, led to a reduction of the EBV capsid antigen content of the EB1 and EB3 cells lines as determined by indirect immunofluorescence, and M. arginini infection enhanced this reduction. The synthesis of two immune products, interferon and macrophage migration inhibition factor, was enhanced by growing the cell lines in medium containing arginine at a concentration of 0.1 mM, but the RPMI 1788 cell line produced much less of both products than EB1 or EB3 under these conditions. Infection of the cell lines with M. arginini reduced the amount of interferon produced and completely inhibited macrophage migration inhibition factor synthesis. The addition of arginine to a final concentration of 0.6 mM in the growth medium caused a dual effect: the EB1 and EB3 cell lines maintained the original level of EBV capsid antigens, even when infected with M. arginini; immune product synthesis was greatly reduced or completely inhibited by the addition of arginine, and M. arginini infection caused no further reduction of immune product synthesis.
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PMID:Control of interferon, migration inhibition factor, and expression of virus capsid antigens in Burkitt's lymphoma-derived cell lines: role of L-arginine. 436 72

The occurrence of infection with respiratory syncytial (RS) virus and Mycoplasma pneumoniae was determined over a 6-year period among residents of Tecumseh, Michigan by isolation and serology. RS virus infection was detected for a variable time each year during the months extending from November to May. There was little viral activity in intervals between these periods of prevalence, which occurred on an alternating short-long cycle. Higher infection rates were detected in periods preceding the long interval than were detected in periods preceding the short interval. Viruses isolated from serial annual outbreaks did not show any sequential changes in antigens, although some variation in antigenic structure was apparent. Infections were common in school-age children, indicating the role of this population in transmission. Young girls were infected as often as young boys, suggesting that observed differences in occurrence of illness must be related to differences in expression of infection. In contrast to RS virus, M. pneumoniae did not appear and disappear annually, but like it, the school-age group was most heavily involved in infection.
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PMID:The Tecumseh study of respiratory illness. VII. Further observations on the occurrence of respiratory syncytial virus and Mycoplasma pneumoniae infections. 437 87

The association of human cytomegalovirus with mink and rabbit lung cells was studied. Strain AD-169 was used which was free of Mycoplasma and other contaminating agents. It was found to be incapable of productively infecting mink lung cells. Infection appeared to be initiated but aborted at an early stage. This was indicated by indirect immunofluorescence, assays of culture supernatants and cell lysates for infectious virus, electron microscopy of ultra-thin sections of infected cells, labelling of virus and viral DNA with 3H-thymidine and assay of virally-induced DNA polymerase at various times after infection. On the other hand, using these methods. AD-169 was found to infect rabbit lung cells, the virus being produced in low amounts over a period of up to one month after infection. At this time, focal areas of infection were still apparent and 15 per cent of the cells expressed nuclear viral antigens as shown by immunofluorescence. The viral genome was assumed to have become latent in some rabbit cells with a few being capable of producing infectious virus.
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PMID:Association of human cytomegalovirus (HCMV) with mink and rabbit lung cells. 626 19

The pathogenicity and immunosuppressive capability of five strains of Marek's disease herpesvirus (MDHV) was examined. Three of the strains (ALA, MISS, NCS) were isolated from flocks experiencing vaccine breaks while the other two strains (GA, HN) represented prototype virulent and avirulent viruses. Pathogenicity of MDHV strains was evaluated on their ability to cause mortality, their ability to cause gross or microscopic lesions, and the median latent period to death (MLPD) for each strain. Antibody responses to Mycoplasma synoviae (MS) were tested by the serum plate agglutination and hemagglutination inhibition tests. Chicks infected with the virulent strains of MDHV had greater mortality, greater lesion incidence, and shorter MLPD that did chicks infected with the avirulent HN strain. Infection with virulent strains reduced the antibody response to MS and caused severe bursal lesions. Chicks infected with the avirulent HN strain exhibited a slight immunosuppression, but they had no evidence of bursal destruction.
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PMID:Serological responses to Mycoplasma synoviae in chickens infected with virulent or avirulent strains of Marek's disease virus. 626 80

Eosinophilia of more than 50% was observed for a period of ten days in the cerebrospinal fluid (CSF) of a patient with acute meningomyelitis and paraplegia. Serologic studies suggested the simultaneous infection with mycoplasma pneumoniae and Coxsackie A 09 as being a likely cause of meningomyelitis. This case demonstrates that pronounced CSF eosinophilia may be observed for a short period in non-parasitic infections of the central nervous system. parasitic infestation may be assumed only when eosinophilia persists for several months.
Infection 1982 Jan
PMID:[Eosinophilic meningomyelitis (author's transl)]. 627 22

The authors analyse 40 cases of erythema multiforme (including twenty children under fifteen) seen over a five-year period at the Sick Children's Hospital in Bordeaux, Bullous erythematous target lesions of the skin were associated, in most cases, with pluri-orificial ulcerations on the mucous membranes and, less frequently, with more or less severe systemic or visceral symptoms. Borderline cases were observed, associating features of erythema multiforme simplex and of Lyell disease with variable degrees of dermoepidermal blistering and epidermal necrosis. Infection (32.5% of cases) is a more common etiology in children than in adults; the main pathogens are herpes simplex virus, vaccinia pox virus, and Mycoplasma pneumoniae. Drug-induced forms (37% of cases), which are more often seen in adults than in children, are usually due to sulfonamides or antiinflammatory agents. In 30% of cases, no etiology could be demonstrated. Attention is drawn to the frequency of facial vespertilial erythema, as well as the possible occurrence of severe conjunctival sequellae. The connections between erythema multiforme, fixed drug-induced eruptions, and Lyell disease are discussed: only the last, which implies dermoepidermal cleavage, can be categorized with erythema multiforme. The staphylococcal scalded skin syndrome, in which the epidermolysin of Staphylococcus aureus type II 71 is responsible for a superficial cleavage, proceeds from entirely different mechanisms and should be regarded as totally distinct from erythema multiforme.
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PMID:[Clinical and etiological aspects of erythema multiforme. A propos of 40 cases]. 630 87

Among women attending a sexually transmitted disease (STD) clinic in Nairobi with vaginal discharge, Neisseria gonorrhoeae and Chlamydia trachomatis were isolated from the cervix in 32 (26%) of 122 and four (7%) of 58 women respectively. Infection with Trichomonas vaginalis, Candida albicans, Gardnerella vaginalis, and Mycoplasma spp were diagnosed in 42 of 122 (34%), 26 of 110 (24%), 75 of 100 (75%), and 42 of 89 (47%) women respectively. Mixed infections with at least two pathogens were found in 23 (26%) of 89 women examined for all microorganisms. Infection with N gonorrhoeae was significantly associated with abdominal pain.
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PMID:Microbiology of vaginal discharge in Nairobi, Kenya. 640 73

The immunity to Mycoplasma pneumoniae was studied by periodic collection of sera up to 15 years after infection. Sera were tested for antilipid antibodies by complement fixation. Antibody levels remained elevated for two to nine years after pneumonia but usually fell sharply after the second year in persons with milder symptoms. Infection rates were at least six times higher in comparison groups than in previous pneumonia patients. Schoolchildren with serologic evidence of infection, but without pneumonia, during the 1966-1967 epidemic were not protected during the next epidemic (1974). Children with evidence of infection during the first two years of life were at no higher risk of clinical pneumonia (immunopathological response) at school age than those without previous known exposure. The current study suggests that naturally acquired infection induces partial immunity which lasts longer after pneumonia than after mild infections.
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PMID:Naturally acquired immunity to pneumonia due to Mycoplasma pneumoniae. 640 17

Anaerobic organisms are the predominant etiologic agents in female genital tract infections. This article describes the conditions necessary for anaerobic growth, cites the diseases in which these organisms play a role, and outlines therapy for anaerobic genital infections. As interest in anaerobic bacteria has increased and culture techniques have improved, the number and variety of species of organisms has grown. Infections generally consist of several anaerobic species with 1 or more aerobic species. It is unclear whether additional organisms such as mycoplasma species or chlamydia impact on the establishment of genital tract infections, and whether multiple anaerobic organisms are needed to establish and maintain infection. For clinical infection to develop, an alteration in either host resistance or numbers of bacteria present must occur. Infections are usually associated with a compromised host whose defense mechanisms have been altered by natural causes or medical interventions such as trauma, surgery, irradiation, steroid treatment, immunosuppressive agents, cytotoxic agents, and certain antibiotics. Infections are classified as either hospital-acquired or community-acquired. The latter category includes pelvic inflammatory disease, pelvic thrombophlebitis, septic abortion, and premature rupture of the membranes. Hospital-acquired infections include postcesarean section endometritis, postoperative pelvic infections, wound infections, hospital-terminated pregnancy, septic thrombophlebitis, and pelvic abscess. Most diseases caused by anaerobic bacteria are characterized by tissue necrosis and abscess formation and an indolent or chronic course. Therapy options include supportive therapy with fluids and blood, administration of antibiotics, and surgical drainage. Initial therapy with full supportive endeavors and full-dose antimicrobial therapy is preferable to planned sequential antibiotic management. In vitro activity against anaerobes and aerobic organisms, tissue penetration, and toxicity should be considered in selecting antimicrobial agents. High-dose single agent chemotherapy is effective in early infections, whereas late infections require double or triple therapy.
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PMID:Infections in the female genital tract. 641 23


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