Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026918 (Mycobacterium)
 52,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

At our institution, tincture of benzoin solution is commonly used as a topical adhesive agent. As a cost-saving practice, multiple-dose bottles are routinely used in the operating rooms and the clinic on multiple patients. Although clinically pathogenic organisms are known to be capable of survival in both benzoin and its isopropyl alcohol solvent, no prior controlled studies have investigated the potential for tincture of benzoin solution to support the growth of specific pathogens under clinically relevant conditions. In this study, multiple aerobic, anaerobic, and spore-forming bacteria were exposed to tincture of benzoin solution, as well as Candida albicans and Mycobacterium fortuitum. Bacillus cereus was the only index organism demonstrating a clear ability to survive a 15 minute incubation in tincture of benzoin, although 24 hours of exposure to tincture of benzoin resulted in no subsequent viable cultures of this organism after 72 hours of incubation. Thus although certain bacilli might, under ideal circumstances, remain viable and infectious within multiple-dose bottles of tincture of benzoin, the risk of causing iatrogenic infection appears to be rather minimal. Still, the use of multiple-dose dispensers of topical agents, particularly in surgical patients, should be carefully scrutinized for their clinical risk-to-economic benefit ratio.
Mil Med 1996 Mar
PMID:Tincture of benzoin: clinical and microbiological implications of reusable containers. 863 41

Mycobacterium tuberculosis infrequently infects muscle. Two cases of muscle involvement complicating tuberculosis (TB), one as a result of infection and a second resulting from the treatment of TB, are reported. Thirteen previous cases are summarized. The pathology, pathogenesis, clinical features, differential diagnosis, and treatment of TB myopathy are discussed.
Mil Med 1997 Mar
PMID:Myopathy in tuberculosis: two presumptive cases and a review of the literature. 912 73

Health care workers (HCW) are at risk of occupationally acquiring Mycobacterium tuberculosis (TB) infection. The Centers for Disease Control and Prevention has published guidelines for health care facilities to protect HCW. One of the recommended elements is TB infection surveillance among HCW using purified protein derivative (PPD) skin testing and analysis of the data by occupational group and work location to determine areas of increased risk of infection. At the military medical center (MMC) we studied, occupational groups with statistically significant (p < 0.05) above-average PPD conversion risk (> 1.1%/year) included respiratory therapists (15.6%/year), nursing technicians (2.3%/year), and military personnel (1.6%/year). Maintenance and engineering workers (2.6%/year), food service workers (2.5%/year), laboratory workers (2.0%/year), custodial workers (1.8%/year), and practical nurses (1.7%/year) had above-average, but not statistically significant, risk. The fourth floor of the MMC had 39% (21/54) of the converters. The surveillance program also uncovered 235 individuals who had not completed adequate prophylactic therapy, and a case of active TB in a laboratory worker.
Mil Med 1997 May
PMID:Tuberculosis skin test conversion among health care workers at a military medical center. 915 4

The epidemiology of tuberculosis in this country is changing because of a combination of biological and social factors. The recent use of DNA fingerprinting of Mycobacterium tuberculosis using restriction-fragment-length polymorphism analysis has suggested that nearly one-third of new cases of tuberculosis being reported in a large metropolitan city is a result of recent infection. The immunosuppression of individuals with the human immunodeficiency virus and the prevalence of multiple drug-resistant tuberculosis has resulted in a renewed interest in the epidemiology and prevention of this disease. To determine the magnitude of the problem in the U.S. Navy enlisted population, a computer search of more than one million inpatient hospitalization records from January 1980 to December 1994 was performed. Total first hospitalization rates for all cases of tuberculosis during this period ranged from 2.2 per 100,000 person-years at risk in white females to 27.5 per 100,000 person-years in males, race "other" (includes mostly Filipinos and Asian-Americans). First hospitalization rates across all cases of tuberculosis declined during this period from a high of 8.7 per 100,000 in 1980 to a low of 2.2 per 100,000 in 1994.
Mil Med 1998 Feb
PMID:Hospitalization rates of tuberculosis in U.S. Navy enlisted personnel: a 15-year perspective. 950 95

Breast infections caused by Mycobacterium tuberculosis, although rare in western countries, should not be forgotten as a cause of a breast lump presenting clinically and radiologically as a carcinoma in the older patient who gives a history of previous tuberculosis. We report the case of an 84-year-old woman with a breast lump showing noncaseating granulomas on histology who developed a sinus track after excision biopsy of the lump. The patient responded to empiric treatment with anti-tuberculosis drugs and remains well 2 years after presentation.
Mil Med 2000 Oct
PMID:Tuberculosis of the breast presenting as carcinoma. 1105 Aug 80

At present, the use of molecular probes and polymerase chain reaction (PCR) for the identification of microorganisms in body fluids or tissues is becoming more commonplace. There is an added advantage when serological or culture methods are difficult, expensive, or unavailable. Slow-growing or fastidious microorganisms, including Mycobacterium tuberculosis, spirochetes, viruses, and the dimorphic fungi, can be detected rapidly using these techniques. The presence of different chromosomal or plasmid-mediated antibiotic-resistant markers can also be determined. PCR is an extremely powerful tool that has been applied to research, and more recently it has been used to augment standard clinical applications. It is a very simple process that can amplify nucleic acid sequences, both DNA and RNA, a million times over. The sensitivity, rapidity, broad applicability, and compactness of this technology make it an ideal candidate for use in the military arena. We recently established a molecular biology laboratory at a Deployable Medical System at the Camp Parks Army Reserve Training Facility in Dublin, California. This article will briefly summarize the use of PCR and its applicability in the air-transportable hospital field environment. Proper handling, processing, and testing as well as the requirements for setting up a molecular biology laboratory will be discussed. Finally, the benefits and disadvantages of using PCR-based techniques in the deployed field environment will be considered.
Mil Med 2000 Nov
PMID:Feasibility determination for use of polymerase chain reaction in the U.S. Air Force air-transportable hospital field environment: lessons learned. 1114 25

The aim of this retrospective study was to investigate susceptibility rates of Mycobacterium tuberculosis complex (MTBC) isolates against streptomycin, rifampicin, isoniazid, and ethambutol between January 1998 and December 2000 in the Turkish Army. Specimens collected from patients were cultured both conventionally and radiometrically. Differentiation of MTBC bacteria from Mycobacteria other than tuberculosis bacilli was made by the BACTEC p-nitro-alpha-acetyl-amino-beta-hydroxypropiophenone test. Susceptibility testing of MTBC isolates was performed using the BACTEC radiometric susceptibility assay for mycobacteria. Most of the specimens originated from respiratory system. A total of 98 isolates in 1998, 123 isolates in 1999, and 84 isolates in 2000 were obtained and identified as MTBC using the radiometric BACTEC TB460 system. Initial resistance was most frequent to isoniazid followed by ethambutol, streptomycin , and rifampicin in this study period. The differences between resistance rates were not statistically significant on an annual basis. None of these isolates was resistant to all four antimycobacterial agents. Although resistance rates of our isolates were not as high as previously reported by some authors from Turkey and there was no significant difference between the annual susceptibility rates, routine screening of antituberculosis drug susceptibility should be continued to control the resistance development and its spread.
Mil Med 2003 Jan
PMID:Resistance patterns of Mycobacterium tuberculosis complex isolates in the Turkish Army from 1998 to 2000. 1254 41

A Marine deployed aboard a U.S. Navy amphibious ship had smear-positive, cavitary pulmonary tuberculosis (TB). Contact investigation ultimately found 21 active cases of TB among sailors and Marines who were aboard the affected ship. Approximately 3 months lapsed between onset of the source patient's illness and appropriate diagnosis and treatment. During the contact investigation, 3,338 persons received tuberculin skin tests and 712 were identified as new latent tuberculosis infection cases. Four persons diagnosed with latent tuberculosis infection developed active TB because of poor compliance with treatment. After personnel disembarked from the ship, persistent efforts to identify persons with active disease and latent infections were successful in controlling further spread of tuberculosis in military units and local communities. The Mycobacterium tuberculosis bacteria isolated from the source patient and 16 of the other active cases were susceptible to all drugs commonly used to treat TB.
Mil Med 2003 Jul
PMID:Tuberculosis outbreak investigation of a U.S. Navy amphibious ship crew and the Marine expeditionary unit aboard, 1998. 1290 59

Pulmonary tuberculosis (TB) was diagnosed in a sailor aboard the U.S.S. Ronald Reagan; an investigation was conducted to determine a screening strategy for 1,172 civilian passengers who were aboard during a temporary guest rider program. Sailors were screened for latent TB infection (LTBI) and TB disease. A case-control study was conducted among sailors to determine factors associated with new LTBI. No secondary TB disease was identified; 13% of close contacts had new LTBI. Factors associated with new LTBI among sailors were having been born outside the United States (adjusted odds ratio = 2.80; 95% confidence interval, 1.55--5.07) and being a carrier air wing member (adjusted odds ratio = 2.89; 95% confidence interval, 1.83--4.58). Among 38 civilian passengers berthed near the patient, 1 (3%) had LTBI. The investigation results indicated that Mycobacterium tuberculosis transmission was minimal and eliminated unnecessary TB screening for 1,134 civilians which saved public health resources.
Mil Med 2008 Jun
PMID:Investigation of Mycobacterium tuberculosis transmission aboard the U.S.S. Ronald Reagan, 2006. 1859 24

Mycobacterium kansasii is a common cause of pulmonary infection as a result of nontuberculous mycobacteria, but is less commonly described as a cause of an orthopedic infection. We present the first case of M. kansasii subacromial septic bursitis in an immunocompromised host. This case demonstrates the diagnostic and treatment challenges associated with orthopedic infections caused by M. kansasii.
Mil Med 2012 May
PMID:Septic subacromial bursitis caused by Mycobacterium kansasii in an immunocompromised host. 2264 93


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