Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026918 (Mycobacterium)
 52,428 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three groups, each of five calves, four to seven months old, were inoculated intranasally with different numbers of Mycobacterium bovis. Infection was established readily in the calves which received an inoculum containing either 10(6) or 10(4) colony forming units (cfu). After every infection there was a lag period during which the organisms could not be isolated from specimens of nasal mucus. All the animals excreted M bovis and the time of commencement, quantity and duration of excretion appeared to be related to the inoculation dose. Excretion continued for many weeks, and for two calves excretion became intermittent over many months. All the calves which were given inocula of 92 cfu failed to develop the disease and no immunological responses were detected; however, M bovis was isolated from nasal secretions from one of these animals 100 days after inoculation.
Vet Rec 1988 Sep 24
PMID:Excretion of Mycobacterium bovis by experimentally infected cattle. 305 17

Subclinical mastitis caused by streptococcal infections affected 27 of 83 cows in a commercial dairy herd. Between three and six weeks after intramammary treatment of these cows with cloxacillin, 16 (59 per cent) of the treated cows developed acute clinical mastitis associated with Mycobacterium smegmatis. None of the untreated cows was affected. Infected quarters were moderately hypertrophied and fine clots were present in the milk for three to four weeks. No cows showed systemic signs of illness. Studies carried out over 12 months showed that infected cows shed M smegmatis for three to four months and affected quarters remained hypertrophied in all but one cow after 12 months. The mean milk cell count of affected quarters fell slowly from 4,850,000/ml in the acute stage to 810,000/ml five months later and 620,000/ml 12 months later, suggesting that the organism persisted in the udder. The estimated mean loss in lactation yield for cows with M smegmatis mastitis was 10.8 per cent. Losses were greatest when the hind quarters were involved (mean 28 per cent for cows with both hind quarters affected). Ten of the 16 affected cows were ultimately culled owing to serious reductions in yield.
Vet Rec 1988 Mar 19
PMID:An investigation of mastitis due to S agalactiae, S uberis and M smegmatis in a dairy herd. 328 53

Tuberculosis of the cerebrum was diagnosed in a 21-month-old chicken. Tuberculous lesions were also found in the liver, spleen, lungs, intestinal walls, skeletal muscles, bone marrow, heart wall and ovaries. Mycobacterium avium was isolated from the brain, liver and the lungs.
Vet Rec 1988 Mar 19
PMID:Avian cerebral tuberculosis. 337 94

The recent history of tuberculosis infection in cattle in Staffordshire is described, showing how a problem area in the north of the county was identified. The subsequent culture of Mycobacterium bovis from badger faeces and a badger carcase is reported together with the operations to remove badgers from the area.
Vet Rec 1987 Mar 14
PMID:Tuberculosis infection in cattle and badgers in an area of Staffordshire. 355 18

After several years of unsuccessful efforts to eradicate paratuberculosis in goats in Norway by conventional methods such as general hygienic precautions and the isolation and slaughtering of clinically affected and serologically positive animals, a vaccination programme was initiated in 1967. The vaccine used consists of two live attenuated strains of Mycobacterium paratuberculosis suspended in a mixture of liquid paraffin, olive oil and pumice powder. The vaccine may be stored at 4 degrees C for two weeks, the dose is 1 ml and the goat kids are vaccinated at the age of two to four weeks. The efficacy of the vaccine has been judged mainly by post mortem examination of vaccinated and unvaccinated goats in the period 1967-82. During this period about 131,000 goats were vaccinated and, based on the post mortem examination of 15,219 goats, the infection rate was reduced from 53 to 1 per cent. Moreover, infection occurred almost exclusively in goats which for some reason or other had not been vaccinated or which had been too old when vaccinated. The results of these examinations showed that the adjuvanted vaccine with live M paratuberculosis bacteria offers a high degree of protection against paratuberculosis in goats.
Vet Rec 1985 Apr 20
PMID:Control of paratuberculosis (Johne's disease) in goats by vaccination. 400 70

Evidence is presented suggesting that a rec mutation in one strain (presumably female) of a mating pair of Mycobacterium smegmatis strains prevented the appearance of recombinants, whereas a rec mutation in the other strain (presumably male) did not.
 ...
PMID:Effect of ultraviolet-sensitive mutants on gene inheritance in mycobacterial matings. 481 52

Tissues from 130 wild deer shot by hunters in County Wicklow, Ireland in 1983-1984 were examined for evidence of tuberculosis. The tissues examined included the lymph nodes of the head, the lung substances and associated lymph nodes, the hepatic lymph nodes and kidneys. Gross lesions were found in five deer. Mycobacteria isolated from the tissues were classified as Mycobacterium bovis on the basis of cultural, biochemical and biological tests in guinea pigs and rabbits.
Vet Rec 1984 Dec 08
PMID:Tuberculosis in free-living deer. 639 76

Lymphadenitis of pigs caused by Mycobacterium intracellulare is widely recognised in continental Europe but this is the first report of it in England. No disease was seen on the farm but condemnations of tissues and organs at the slaughterhouse were often than 100 a week and in one week were in excess of 200. The loss was greater to the slaughterhouse than to the farmer because of the constant disruption to the production line. There was no evidence that diseased pigs performed less well than healthy pigs. M intracellulare types 4 and 6 and M xenopi were isolated from diseased pigs. The source of the infection was traced to the sawdust bedding supplied by a local sawmill set in the middle of a forest. Changing the bedding to straw halted the outbreak. From the sawdust M avium types 1 and 4, M fortuitum and M intracellulare type 4 were isolated. The wildlife round the sawmill was investigated as a source of infection. Although M intracellulare type 4 and M avium were isolated from moles and a hedgehog, it was concluded that the wildlife was not involved. There was no evidence of pig to pig transmission.
Vet Rec 1984 May 19
PMID:Avian tuberculosis in pigs: Mycobacterium intracellulare infection in a breeding herd. 674 Aug 82

Two experiments with badgers infected with Mycobacterium bovis are described. In the first, badgers were infected by intravenous inoculation of a bovine isolate of M bovis. The course of the disease in these and its spread to healthy badgers and calves was monitored by clinical, immunological and bacteriological means. In the second experiment a group of naturally infected badgers were observed for a period of up to four years. They were found to excrete M bovis in their faeces for periods of between 165 and 1305 days before they died of tuberculosis or were killed. M bovis was also shed in the urine. The badgers in both experiments were examined regularly and blood samples were taken for complement fixation tests. Faeces, urine, pus and sputum were also collected for cultural and biological tests and the badgers were skin tested using Weybridge bovine and avian tuberculin. The skin tests were uniformly negative while the complement fixation test were positive in some infected badgers but gave very variable results. Only the isolation of M bovis gave a definite diagnosis of tuberculosis in the living badger but a number of badgers which were found to have tuberculosis at post mortem were not detected while alive by this method. Environmental samples from the yards, including badger faeces, soil, hay, scrapings from feeding bowls and water were regularly examined for the presence of M bovis but apart from faeces only one water sample was positive, indicating that the organism did not persist for long in the environment. In both experiments calves developed sensitivity to bovine tuberculin after six months' exposure to infected badgers. The experiments further demonstrate the potential of a badger population to become endemically infected with M bovis and to act as a source of infection for cattle.
Vet Rec 1982 Dec 11
PMID:Laboratory study of Mycobacterium bovis infection in badgers and calves. 676 50

Thirty-nine species of bacteria were isolated from or demonstrated in the abomasal and small and large intestinal mucosa of 23 adult cattle and 41 calves and identified. The bacteria isolated were related to the gross and microscopical lesions. Campylobacters, Clostridium perfringens type A, C sordellii, Actinobacillus lignieresii, Fusobacterium necrophorum, Mycobacterium paratuberculosis, Aeromonas hydrophila and Escherichia coli were all associated with specific lesions. The relationship of other bacteria such as Bacillus licheniformis, Branhamella catarrhalis and Bacteroides vulgatus to lesions in which they were found was discussed. It was concluded that some of the bacteria could be responsible for the lesions in which they were found. However, proof of this supposition could only be obtained by experimental infections of non-immune cattle with pure cultures.
Vet Rec 1983 Jan 01
PMID:Bacteria in enteric lesions of cattle. 682 37


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>