Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026916 (MAC)
 5,226 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty appropriate (mean +/- S.D., gestational age (AGA): 29.9 +/- 1.5 weeks) and 15 small (GA: 34.6 +/- 2.4 weeks) for gestational age (SGA) very low birth weight infants fed banked mature human milk were studied until term for anthropometric parameters: midarm (MAC), chest (CC), head (HC) circumferences, triceps (TSKF) and subscapular (SSKF) skinfold thickness recorded at 15 and 60 s, dynamic skinfold (delta % SKF), muscle (AMA) and fat (AFA) areas, weight and length. In AGA infants, all the parameters at term were significantly lower in extrauterine (EUL) that in intrauterine life (IUL). At term the relative proportion of AFA to total arm area was increased in EUL compared to IUL both in AGA (25.87 +/- 3.8 vs. 23.26 +/- 1.27% respectively, P less than 0.01) and in SGA infants (21.89 +/- 4.63 vs. 18.81 +/- 3.9 respectively, P less than 0.05). SGA infants showed a similar growth in EUL compared to IUL, and a significantly lower AMA and AFA than in AGA infants in EUL. Although HC was in both infants below the 10th centile at term, the ratio weight/HC2 suggests a relative preservation of head growth in EUL compared to IUL (AGA: 20.72 less than 0.87 vs. 22.65 +/- 1.46 respectively, P less than 0.001; SGA; 20.82 +/- 1.16 vs. 21.62 +/- 1.86 respectively, NS). Delta %SKF were negatively correlated with post-conceptional age suggesting a loss of extracellular water in AGA (delta %TSKF: r = -0.287, P less than 0.02) and in SGA infants (delta %TSKF: r = -0.301, P less than 0.02; delta %SSKF: r = -0.316, P less than 0.02). An intrauterine model of discrimination between AGA and SGA infants does not apply to EUL. An equation was established in SGA infants with the best discriminant parameters giving a predictive post-conceptional age: post-conceptual age (PCA) (weeks) = 0.276 HC (cm) + 0.723 CC (cm) - 0.122 MAC (cm) + 0.5 TSKF (mm) + 10.173, (r = 0.867, P less than 0.001) allowing a clear discrimination between AGA and SGA infants. These results suggest that infants show quite different growth patterns between IUL and EUL both for AGA and SGA infants.
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PMID:Assessment of proportional growth of very low birth weight infants fed banked human milk. 367 20

We report a study of 1,953 patients whose laboratory records from 1972 through 1983 at the Massachusetts Mycobacteria Reference Laboratory indicated the isolation of Mycobacterium avium complex (MAC) organisms. At least one clinical specimen from each patient during this period exhibited the organism. The incidence of isolation of MAC has increased fivefold since 1972, with a doubling of the number of patients with positive MAC specimens from normally sterile sites occurring since 1980. A concomitant increase of more than fourfold in other nontuberculous mycobacteria has occurred. Most isolates came from high-density population centers. Communities whose drinking water comes from a distant rather than a local source were more likely to have patients with MAC.
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PMID:Mycobacterium avium complex, an emerging pathogen in Massachusetts. 387 80

Experimental hygienic-toxical study was carried out on amide herbicide lasso, aiming at its hygienic standardization in water. The studies were carried out in three aspects for the determination of its effect upon the organoleptic qualities of water, on the sanitary regime of water-reservoirs and toxic effect on organism. Threshold and subthershold concentrations of the deleterious effect on colour, small and taste of water were determined as well as on B0N5, on sanitary-indication microflora and on cold blooded organisms. The toxicological parameters for acute, subacute and chronic oral toxicity on albino rats were established. On the base of the experimental studies, differentiated hygienic norms (MAC) of lasso were elaborated in the three categories water-reservoirs - I mg/1 for I category and 5 mg/1 for II and II category.
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PMID:[Experimental studies for the hygienic standardization of Lasso in water]. 679 19

During the last four decades in all the Central and East European countries it was intended that prevention of the adverse health effects of chemicals in occupational and environmental settings, including the drinking water and food basket of populations, be achieved by determination and compulsory observance of hygienic limit values (MAC, TLV, ADI). The authors have tried to demonstrate some specific features of risk assessment of exposure to chemicals in environmental and occupational settings. Although the approach to risk assessment and management was similar in many respects in the CMEA countries, implementation and hygienic practice was different in the individual countries in terms of many details and effectiveness. Due to long lasting experience with environmental pollution including health impact on humans, such as in the "Dirty Triangle of Europe" and other heavily contaminated areas a considerable knowledge has been gained. The authors recommend to analyse critically and evaluate the knowledge and experience and present it to the international scientific community and international institutions such as UNEP, ILO, IPCS, IRPTC and last but not least, OECD.
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PMID:Risk assessment of chemicals--a central European perspective. 769 23

Pulmonary mycobacteriosis is usually caused by Mycobacterium tuberculosis or Mycobacterium avium complex. There are, however, other slow-growing mycobacteria that can cause pulmonary infection. Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium xenopi, Mycobacterium szulgai and Mycobacterium simiae typically infect middle-aged to elderly persons with preexisting lung disease. Differentiation of infection with these five mycobacteria from infection with Mycobacterium tuberculosis, by culture and determination of the antimicrobial susceptibility pattern of the organism are important for several reasons. All five organisms are found in water and soil. They probably infect humans from environmental habitats; human-to-human spread of infection is thought not to occur. Furthermore, isolation of the organisms in culture may represent contamination of the specimen or colonization of the patient, and not necessarily an infection. Finally, although the antituberculosis drugs-isoniazid, ethambutol, rifampin and streptomycin-have been used for treatment of infection with these five organisms, there are often differences between the antimycobacterial susceptibility patterns of Mycobacterium tuberculosis and those of the non-tuberculous mycobacteria. Thus, the optimal choice of drug therapy may differ from that used for tuberculosis.
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PMID:Pulmonary infections caused by less frequently encountered slow-growing environmental mycobacteria. 769 20

As part of an epidemiologic study of Mycobacterium avium complex (MAC) infection in San Francisco, water, food and soil samples were collected from the home environment of 290 persons with human immunodeficiency virus (HIV) infection and cultured for mycobacteria. Isolates recovered from the environment were compared with isolates cultured from study patients. Although mycobacteria were recovered from numerous environmental samples, isolates reactive with MAC-specific DNA probes were recovered from only four of 528 (0.76%) water samples and one of 397 (0.25%) food samples. The species M. avium was recovered from one water (0.19%) and one food sample. In contrast, MAC was recovered from 55% and M. avium from 27% of soil samples taken from potted plants in patients' home. Speciation of 76 MAC isolates from study patients showed all isolates belonged to the species M. avium. With use of serotype and multilocus enzyme electrophoresis analysis, some of the soil isolates were found to be similar to isolates recovered from study patients. The results of this study suggest that soil, rather than water, may be a significant reservoir of organisms causing MAC infection in San Francisco.
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PMID:Mycobacterium avium complex in water, food, and soil samples collected from the environment of HIV-infected individuals. 774 96

A case-control study was done to determine risk factors for Mycobacterium avium complex (MAC) disease in persons infected with human immunodeficiency virus (HIV) with < 50 CD4+ cells/mm3. In univariate analysis, cases (n = 83) had lower CD4+ cell counts than controls (n = 177) (median, 10 vs. 17/mm3; P < .001) and were more likely to have consumed hard cheese (odds ratio [OR], 5.44; 95% confidence interval [CI], 1.61-18.4) but were less likely to have taken daily showers (OR, 0.55; 95% CI, 0.33-0.94). In multivariate analysis, CD4+ cell count < 25/mm3 (OR, 3.58; 95% CI, 1.71-7.49) and consumption of hard cheese (OR, 5.63; 95% CI, 1.58-20.1) remained associated with disease, while daily showering (OR, 0.58; 95% CI, 0.28-0.88) remained protective. Increased risk for MAC disease in persons with HIV infection and low CD4+ cell counts is not associated with exposure to water or a variety of other environmental sources but may be associated with consumption of hard cheese.
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PMID:Environmental risk factors for acquisition of Mycobacterium avium complex in persons with human immunodeficiency virus infection. 791 81

Dexmedetomidine (DEX), an alpha 2-receptor agonist, is the pharmacologically active d-isomer of medetomidine, a compound used as a sedative in veterinary medicine. Isoflurane anesthetic requirement (minimum alveolar concentration; MAC), rectal temperature, and cardiorespiratory variables were studied in chronically instrumented Yucatan miniature swine during DEX (20 micrograms/kg of body weight)-induced changes in body temperature. All studies were performed at room temperature of 22 C. The DEX was given as a 2-minute infusion into the left atrium. Each pig was studied twice. For protocol 1, the core temperature of the pigs was maintained at (mean +/- SD) 38.2 +/- 0.5 C by use of a thermostatically controlled water blanket and a heating lamp. For protocol 2, the core temperature was not externally manipulated and it decreased from 38.2 +/- 0.4 C to 32.2 +/- 1.2 C during the more than 3 hours of the protocol. Control isoflurane MAC was 1.66 +/- 0.2% and was 1.74 +/- 0.3% for protocols 1 and 2, respectively; DEX decreased MAC by 34 and 44%, respectively. For protocol 1, reduction in MAC after DEX administration returned by 50 and 80% at 84 and 138 minutes, respectively. If rectal temperature was not maintained (eg, allowed to decrease), MAC was reduced by 57% at the same time as the return to 80% in the swine with maintained body temperature. Respiratory rate and minute ventilation were significantly higher in swine with maintained temperature. The PaCO2 was lower and, accordingly, pH was higher in these swine. Blood pressure and heart rate were not affected by temperature changes.
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PMID:Relation between body temperature and dexmedetomidine-induced minimum alveolar concentration and respiratory changes in isoflurane-anesthetized miniature swine. 797 16

Ruspol is sodium salt of cellulose glycolic acid. Its organoleptic threshold in water is 500 mg/kg. MAC of ruspol in water is recommended on the level 0.5 mg/l.
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PMID:[Hygienic rationale for the maximum allowable concentration of ruspol in water reservoirs]. 800 66

The paper gives the evaluation of chemical hazards according to indexes of digestive tract functional state when harmful chemicals enter human body with drinking water and also according to such specific effects as genital, embryotoxic, carcinogenic, allergic and teratogenic ones. The author offers an express method of developing MAC (maximum allowable concentrations) of harmful substances based on reducing the time of chronic experiments with due account of group regulation.
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PMID:[Assessment of hazardous chemical substances entering water reservoirs of public and domestic water supply]. 803 63


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