Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A growing number of medical research teams have begun to explore the experimental advantages of using a genetic animal model, the nematode worm Caenorhabditis elegans, with a view to enhancing our understanding of genes underlying human congenital disorders. In this study, we have compared sequences of positionally cloned human disease genes with the
C.elegans
database of predicted genes. Drawing on examples from spinal muscular atrophy, polycystic kidney disease,
muscular dystrophy
and Alzheimer's disease, we illustrate how data from
C.elegans
can yield new insights into the function and interactions of human disease genes.
...
PMID:A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. 1076 9
