Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026850 (muscular dystrophy)
 5,870 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective was to find out whether the reduced amount of brown adipose tissue in myopathic hamsters [Am. J. Physiol. 239 (Cell Physiol. 8): C18-C22, 1980] was secondary to a refractoriness to the trophic influence of norepinephrine. However, no evidence for any trophic influence of norepinephrine on brown adipose tissue of either normal or myopathic hamsters could be detected under experimental conditions that have demonstrated such an influence in rats. A mediator other than norepinephrine, melatonin, secreted by the pineal gland, is known to mediate the control of brown adipose tissue growth induced in hamsters by short photoperiod. Further studies of intact or pinealectomized hamsters showed that the pineal gland was not required for either cold- or diet-induced growth of brown adipose tissue. It is concluded that the defect in control of brown adipose tissue size in the hamster with muscular dystrophy is not due either to abnormal control by norepinephrine or to the pineal gland since neither of these appears to participate in the normal regulation of brown adipose tissue size in relation to environmental temperature or to diet.
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PMID:Trophic response of hamster brown adipose tissue: roles of norepinephrine and pineal gland. 650 15

Hamsters with muscular dystrophy (BIO 14.6) have a smaller than normal amount of brown adipose tissue. Two stimuli that promote growth of brown adipose tissue in normal hamsters, short photoperiod and eating a high-fat diet, are here shown to be without effect on brown adipose tissue of myopathic hamsters. Cold-induced growth of brown adipose tissue occurs normally [Am. J. Physiol. 239 (Cell Physiol. 8): C18-C22, 1980]. There is a normal rate of turnover of norepinephrine in brown adipose tissue of the myopathic hamster but a failure of the tissue to hypertrophy in response to norepinephrine is unlikely since norepinephrine does not appear to mediate the trophic response [Am. J. Physiol. 247 (Endocrinol. Metab. 10): E793-E799, 1984]. Denervation results in a marked reduction in size (protein content) of brown adipose tissue of normal hamsters but has very little effect on the size of brown adipose tissue of myopathic hamsters. A central, possibly hypothalamic, defect in the myopathic hamster is postulated to underlie its abnormal control of brown adipose tissue hypertrophy.
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PMID:Defective trophic response of brown adipose tissue of myopathic hamsters. 654 15