Gene/Protein
Disease
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To elucidate the disturbances of myelin metabolism in the nerve tissue of murine
muscular dystrophy
, the lipid composition of and the developmental changes in 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) and
cholesterol ester hydrolase
(CEHase) activities in the purified CNS myelin of dystrophic mice were determined. Several kinds of lipids, total galactolipid and cerebroside sulfatide levels were significantly reduced as compared with controls. Total cholesterol levels in the spinal cord of dystrophic mice were moderately higher. CEHase and, to a lesser degree, CNPase activities were reduced in the purified myelin of the CNS of the dystrophic mice. The reduced myelin CEHase activity in dystrophic mice suggests that impairment of hydrolysis of steryl esters may be important in the development of hypomyelination of the CNS.
...
PMID:Evidence on hypomyelination of central nervous system in murine muscular dystrophy. 298 38
