Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The response of the membrane-bound enzyme
AChE
to changes in temperatures was investigated to test the applicability of the "generalized membrane defect" hypothesis proposed for human myotonic and Duchenne muscular dystrophies to the two forms of
muscular dystrophy
expressed in mice. For intact platelets from homozygous normal and dystrophic mice of both strains, a break (Tc) occurred in the Arrhenius plot of
AChE
activity at approximately 22 C. Solubilization of membrane-bound
AChE
by Triton X-100 produced a nonlinear Arrhenius plot over the temperature range (7.7 C to 37 C) in normal and dystrophic mice of both strains. However, in the presence of phospholipase A2 + C and Triton X-100, a linear Arrhenius plot was produced indicating that the membrane-bound enzyme is normally modulated by a bulk lipid domain as well as by a tightly bound (immobilized) phospholipid domain. The temperature response of platelet
AChE
from normal and dystrophic mice of both strains was not significantly different. These results showing normal temperature kinetics of
AChE
do not lend support to the theory of a membrane defect in the platelets of dystrophic mice.
...
PMID:Evidence against a generalized membrane defect in dystrophic mice platelets. 712 7
We have studied the effect of
muscular dystrophy
by merosin deficiency on mouse thymus acetyl- (
AChE
) and butyrylcholinesterase (BuChE). The organ contains
AChE
and BuChE activities. Merosin deficiency causes an important decrease (46%) in
AChE
specific activity. Thymus produces dimers, monomers and tetramers of
AChE
, and the three kinds of
AChE
mRNAs. The drop in
AChE
activity in dystrophic animals could affect the amount of ACh reaching cholinergic receptors in cells of lymphoid organs.
...
PMID:Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice. 1642 80
