Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diethylstilbestrol
(
DES
) lowers enzyme efflux from isolated mouse skeletal muscle. It also lowers the high serum enzyme activities in Duchenne's
muscular dystrophy
. We have begun a systematic study of
DES
congeners, to identify those portions of the
DES
molecule which are critical to these effects, and to tailor a molecule which might have fewer feminizing effects. The first compound tested was the 3,3' diallyl derivative of
DES
(DAS). It was selected because previous reports indicated that it was as anabolic as
DES
, but only 1/10 to 1/30 as estrogenic. Doses of 20, 100 and 250 microgram/mouse/day were administered in 0.05 ml sesame seed oil vehicle to C57BL/6 mice. Control animals received only the vehicle. In contrast to
DES
which has consistently reduced muscle enzyme efflux 30-50%, DAS was inert. The substitution of the two allyl groups in the 3 and 3' positions blocks access to the neighboring ethyl groups and partially covers the two phenolic hydroxyl groups of
DES
. This suggests that these molecular sites have pertinence to the reduction of enzyme efflux from mouse skeletal muscle by
DES
, and possibly the reduction of the high serum enzyme activities in Duchenne's
muscular dystrophy
.
...
PMID:Abolition of the diethylstilbestrol reduction of enzyme leakage from muscle by a 3,3' diallyl substitution. 89 42
