Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
By means of fructose-1,6-diphosphate selective elution of aldolase isoenzymic forms from the phosphocellulose column the izoenzyme
AC3
was isolated preparatively from the muscles rabbits with experimental E-avitaminosis
muscular dystrophy
. The specific activity of aldolase A4 and
AC3
with pathology differs from that at normal state by fructose-1,6-diphosphate and fructose-1-monophosphate. As to the electrophoretic activity the isoenzymes A4 and
AC3
are similar to the same isoforms at normal state. The values of the Michaelis constants and maximal rate are determined for aldolases A4,
AC3
and C4 at normal state and for A4 and
AC3
with E-avitaminosis. Differences in these parameters are found relative to two substrates for A4 aldolase and
AC3
-hybrid at normal state and with dystrophy.
...
PMID:[Comparative studies of the properties of aldolase isoenzymes A-C in normal rabbit brain and in skeletal muscles from rabbits with E-avitaminosis dystrophy]. 125 54
