Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Duchenne muscular dystrophy (DMD) is a fatal and incurable muscle degenerative disorder. We identify a function of the protease
urokinase plasminogen activator
(
uPA
) in mdx mice, a mouse model of DMD. The expression of
uPA
is induced in mdx dystrophic muscle, and the genetic loss of
uPA
in mdx mice exacerbated muscle dystrophy and reduced muscular function. Bone marrow (BM) transplantation experiments revealed a critical function for BM-derived
uPA
in mdx muscle repair via three mechanisms: (1) by promoting the infiltration of BM-derived inflammatory cells; (2) by preventing the excessive deposition of fibrin; and (3) by promoting myoblast migration. Interestingly, genetic loss of the
uPA
receptor in mdx mice did not exacerbate
muscular dystrophy
in mdx mice, suggesting that
uPA
exerts its effects independently of its receptor. These findings underscore the importance of
uPA
in
muscular dystrophy
.
...
PMID:uPA deficiency exacerbates muscular dystrophy in MDX mice. 1778 20
